COVID-19 and Artificial Intelligence: An Approach to Forecast the Severity of Diagnosis DOI Creative Commons
Ștefan Udriștoiu, Alice Elena Ghenea, Ștefan Udriștoiu

et al.

Life, Journal Year: 2021, Volume and Issue: 11(11), P. 1281 - 1281

Published: Nov. 22, 2021

(1) Background: The new SARS-COV-2 pandemic overwhelmed intensive care units, clinicians, and radiologists, so the development of methods to forecast diagnosis’ severity became a necessity helpful tool. (2) Methods: In this paper, we proposed an artificial intelligence-based multimodal approach future patients with laboratory-confirmed cases SARS-CoV-2 infection. At hospital admission, collected 46 clinical biological variables chest X-ray scans from 475 COVID-19 positively tested patients. An ensemble machine learning algorithms (AI-Score) was developed predict score as mild, moderate, severe for COVID-19-infected Additionally, deep module (CXR-Score) automatically classify images integrate them into AI-Score. (3) Results: AI-Score predicted on testing/control dataset (95 patients) average accuracy 98.59%, specificity 98.97%, sensitivity 97.93%. CXR-Score graded 99.08% images). (4) Conclusions: Our study demonstrated that based integration data accurately positive-tested

Language: Английский

COVID-19 pandemic and alcohol consumption: Impacts and interconnections DOI Creative Commons
Daniela Călina, Thomas Härtung, Ileana Mardare

et al.

Toxicology Reports, Journal Year: 2021, Volume and Issue: 8, P. 529 - 535

Published: Jan. 1, 2021

Alcohol consumption is associated with multiple diseases and might contribute to vulnerability SARS-CoV-2 infection. It can also catalyze exacerbations of mental organic illnesses predispose behaviors an increased risk infection, severity disease but independently sociopathic behavior violence. Globally, millions premature deaths from excessive alcohol occur each year. This paper discusses the effects most important consequences on health population during social isolation lockdown current COVID-19 pandemic.

Language: Английский

Citations

145
Biogenic Zinc Oxide Nanoparticles and Their Biomedical Applications: A Review DOI Open Access
Shruti Jha, Ritu Rani, Sandeep Singh

et al.

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2023, Volume and Issue: 33(6), P. 1437 - 1452

Published: April 20, 2023

Language: Английский

Citations

74
Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications DOI Creative Commons

Shumaila Ijaz,

Javed Iqbal, Banzeer Ahsan Abbasi

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114687 - 114687

Published: April 14, 2023

Cancer is still the leading cause of death worldwide, burdening global medical system. Rosmarinic acid (RA) among first secondary metabolites discovered and it a bioactive compound identified in plants such as Boraginaceae Nepetoideae subfamilies Lamiaceae family, including Thymus masticmasti chinaythia koreana, Ocimum sanctum, Hyptis pectinate. This updated review to highlight chemopreventive chemotherapeutic effects RA its derivatives, thus providing valuable clues for potential development some complementary drugs treatment cancers. Relevant information about RA's derivatives were collected from electronic scientific databases, PubMed/Medline, Scopus, TRIP database, Web Science, Science Direct. The results studies showed numerous significant biological antiviral, antibacterial, anti-inflammatory, anti-tumour, antioxidant antiangiogenic effects. Most on anticancer with corresponding mechanisms are experimental preclinical stage missing evidence clinical trials support research. To open new therapeutic perspectives future must elucidate molecular targets action more detail, human toxic adverse

Language: Английский

Citations

65
Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy DOI Creative Commons
Javad Sharifi‐Rad, Véronique Seidel,

Michalak Izabela

et al.

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: May 1, 2023

Abstract Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has crucial role in cytoprotective response against stress, including cancer growth progression therapy resistance. For this reason, inhibitors are new targets to be studied. Traditional plant-based remedies rich phytochemicals have been used human cancers phenolic compounds known for their chemopreventive properties. This comprehensive review offers updated the as anticancer agents due action on inhibition. In addition, naturally-occurring bioactive covered clinical applications polyphenols inhibitors.

Language: Английский

Citations

54
RETRACTED: Utilizing of (Zinc Oxide Nano-Spray) for Disinfection against “SARS-CoV-2” and Testing Its Biological Effectiveness on Some Biochemical Parameters during (COVID-19 Pandemic)—“ZnO Nanoparticles Have Antiviral Activity against (SARS-CoV-2)” DOI Open Access
Samy M. El‐Megharbel, Mohammed Alsawat, Fawziah A. Al‐Salmi

et al.

Coatings, Journal Year: 2021, Volume and Issue: 11(4), P. 388 - 388

Published: March 29, 2021

A newly synthesized zinc (II) oxide nanoparticle (ZnO-NPs) has been used as a disinfectant Nano-spray for the emerging corona virus (SARS-CoV-2). The obtained nanomaterial of (ZnO) was fully chemically characterized by using different spectroscopic analysis (FT-IR, UV and XRD) surface techniques. ZnO-Nps morphology chemical purity investigated transmission electron microscope (TEM), high resolution (HR-TEM), scanning microscopy (SEM) well energy dispersive X-ray (EDX), Additionally Zeta potential size distribution were measured evaluated to confirm its nano-range scale. Zno-NPs have tested 10% DMSO ddH2O estimation antiviral activity against (SARS-CoV-2) cytotoxicity assay (CC50) inhibitory concentration (IC50). results revealed that (Zno-NPs) anti-SARS-CoV-2 at cytotoxic concentrations in vitro with non-significant selectivity index (CC50/IC50 ≤ 1). current study demonstrated potent low (IC50 = 526 ng/mL) but some effect cell host (CC50 292.2 ng/mL). We recommend (SARS-Cov-2), there are slight side effects on cellular host, so we more prospective studies complexation other compounds reduce toxicity elevate SARS-CoV-2 activities.

Language: Английский

Citations

94
Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis DOI

Zeynab Kavyani,

Vali Musazadeh,

Soroor Fathi

et al.

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 111, P. 109104 - 109104

Published: July 30, 2022

Language: Английский

Citations

61
A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants DOI Open Access
Mohammed M. Alshehri, Cristina Quispe, Jesús Herrera‐Bravo

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 38

Published: Feb. 4, 2022

The use of phytochemicals is gaining interest for the treatment metabolic syndromes over synthetic formulation drugs. Senna evolving as one important plants which have been vastly studied its beneficial effects. Various parts species including root, stem, leaves, and flower are found rich in numerous phytochemicals. In vitro, vivo, clinical experiments established that extracts from diverse effects by acting a strong antioxidant antimicrobial agent. this review, genus comprehensively discussed terms botanical characteristics, traditional use, geographic presence, phytochemical profile. bioactive compound richness contributes to biological activity plant extracts. review emphasizes on vivo vitro anti-infectious properties plant. Preclinical studies confirmed components regard health-promoting activities. safety, side effects, therapeutic limitations also review. Additional research necessary utilize phenolic compounds towards an alternative pharmacological treatments even ingredient functional foods.

Language: Английский

Citations

56
Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation DOI Open Access
Javad Sharifi‐Rad, Simona Rapposelli, Simona Sestito

et al.

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(9), P. 1515 - 1515

Published: Sept. 15, 2022

Alzheimer's disease (AD) is a neurodegenerative characterized by tangle-shaped accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The pathophysiological mechanism involves the presence Aβ-amyloid peptide, protein, oxidative stress, an exacerbated neuro-inflammatory response. This review aims to offer updated compendium most recent promising advances AD treatment through administration phytochemicals. literature survey was carried out electronic search following specialized databases PubMed/Medline, Embase, TRIP database, Google Scholar, Wiley, Web Science regarding published works that included molecular mechanisms signaling pathways targeted phytochemicals various experimental models vitro vivo. results studies showed use against has gained relevance due their antioxidant, anti-neuroinflammatory, anti-amyloid, anti-hyperphosphorylation properties protein. Some bioactive compounds from plants have been shown ability prevent stop progression Alzheimer's.

Language: Английский

Citations

49
Camellia sinensis: Insights on its molecular mechanisms of action towards nutraceutical, anticancer potential and other therapeutic applications DOI Creative Commons
Priya Chaudhary, Debasis Mitra, Pradeep K. Das Mohapatra

et al.

Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 16(5), P. 104680 - 104680

Published: Feb. 15, 2023

The Camellia sinensis plant provides a wide diversity of black, green, oolong, yellow, brick dark, and white tea. Tea is one the majorly used beverages across globe, succeeds only in water for fitness pleasure. Generally, green tea has been preferred more as compared to other teas due its main constituent e.g. polyphenols which contribute various health benefits. aim this updated comprehensive review bring together latest data on phytochemistry pharmacological properties highlight therapeutic prospects bioactive compounds so that full medicinal potential can be realised. A published studies topic was performed by searching PubMed/MedLine, Scopus, Google scholar, Web Science databases from 1999 2022. results analysed showed are four prime flavonoids catechins: epigallocatechin gallate (EGCG), epicatechin (ECG), (EGC), (EC) along with beneficial biological broad heterogeneity disorders, including anticancer, neuroprotective, antibacterial, antiviral, antifungal, antiobesity, antidiabetes antiglaucoma activities. Poor absorption low bioavailability limiting aspects their use. More human clinical approaching nanoformulation techniques nanoparticles transport target phytochemical increase efficacy needed future.

Language: Английский

Citations

35
Siraitia grosvenorii As a Homologue of Food and Medicine: A Review of Biological Activity, Mechanisms of Action, Synthetic Biology, and Applications in Future Food DOI
Yuxi Guo, Xuefeng Chen, Pin Gong

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(13), P. 6850 - 6870

Published: March 21, 2024

Siraitia grosvenorii (SG), also known as Luo Han Guo or Monk fruit, boasts a significant history in food and medicine. This review delves into SG's historical role varied applications traditional Chinese culture, examining its phytochemical composition the health benefits of bioactive compounds. It further explores biological activities, including antioxidant, anti-inflammatory, antidiabetic properties elucidates mechanisms behind these effects. The highlights recent synthetic biology advances enhancing production compounds, presenting new opportunities for broadening their availability. Ultimately, this emphasizes value medicine, showcasing cultural importance, phytochemistry, functions, action mechanisms, sustainable use.

Language: Английский

Citations

15