Chronic inflammation in the etiology of disease across the life span

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(12), P. 1822 - 1832

Published: Dec. 1, 2019

Language: Английский

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The role of inflammation in depression: from evolutionary imperative to modern treatment target

Nature reviews. Immunology, Journal Year: 2015, Volume and Issue: 16(1), P. 22 - 34

Published: Dec. 29, 2015

Language: Английский

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The Lancet Commission on global mental health and sustainable development

The Lancet, Journal Year: 2018, Volume and Issue: 392(10157), P. 1553 - 1598

Published: Oct. 1, 2018

Language: Английский

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Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation

Biological Psychiatry, Journal Year: 2015, Volume and Issue: 80(1), P. 40 - 52

Published: June 4, 2015

Language: Английский

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Life’s Essential 8: Updating and Enhancing the American Heart Association’s Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association

Circulation, Journal Year: 2022, Volume and Issue: 146(5)

Published: June 29, 2022

In 2010, the American Heart Association defined a novel construct of cardiovascular health to promote paradigm shift from focus solely on disease treatment one inclusive positive promotion and preservation across life course in populations individuals. Extensive subsequent evidence has provided insights into strengths limitations original approach defining quantifying health. response, convened writing group recommend enhancements updates. The definition quantification each metrics (Life’s Simple 7) were evaluated for responsiveness interindividual variation intraindividual change. New considered, age spectrum was expanded include entire course. foundational contexts social determinants psychological addressed as crucial factors optimizing preserving This presidential advisory introduces an enhanced assessing health: Life’s Essential 8. components 8 diet (updated), physical activity, nicotine exposure sleep (new), body mass index, blood lipids glucose pressure. Each metric new scoring algorithm ranging 0 100 points, allowing generation composite score (the unweighted average all components) that also varies points. Methods implementing assessment longitudinal monitoring are discussed, potential data sources tools widespread adoption policy, public health, clinical, institutional, community settings.

Language: Английский

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Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective

Annual Review of Psychology, Journal Year: 2014, Volume and Issue: 66(1), P. 143 - 172

Published: July 25, 2014

Sleep has a critical role in promoting health. Research over the past decade documented that sleep disturbance powerful influence on risk of infectious disease, occurrence and progression several major medical illnesses including cardiovascular disease cancer, incidence depression. Increasingly, field focused identifying biological mechanisms underlying these effects. This review highlights impact adaptive innate immunity, with consideration dynamics disturbance, restriction, insomnia (a) antiviral immune responses consequences for vaccine (b) proinflammatory implications also discusses neuroendocrine autonomic neural underpinnings linking immunity reciprocal links between inflammatory biology. Finally, interventions are discussed as effective strategies to improve sleep, potential opportunities identified promote health therapeutic control chronic infectious, inflammatory, neuropsychiatric diseases.

Language: Английский

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State of the Art Review: Depression, Stress, Anxiety, and Cardiovascular Disease

American Journal of Hypertension, Journal Year: 2015, Volume and Issue: 28(11), P. 1295 - 1302

Published: April 24, 2015

The notion that psychological states can influence physical health is hardly new, and perhaps nowhere has the mind-body connection been better studied than in cardiovascular disease (CVD). Recently, large prospective epidemiologic studies smaller basic science have firmly established a between CVD several conditions, including depression, chronic stress, posttraumatic stress disorder (PTSD), anxiety. In addition, numerous clinical trials conducted to attempt prevent or lessen impact of these conditions on health. this article, we review connecting stress/PTSD, anxiety CVD, focusing findings from last 5 years. For each mental condition, first examine evidence establishing link with CVD. We then describe potential underlying mechanisms finally discuss treatment directions for future research.

Language: Английский

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Depression in sleep disturbance: A review on a bidirectional relationship, mechanisms and treatment

Journal of Cellular and Molecular Medicine, Journal Year: 2019, Volume and Issue: 23(4), P. 2324 - 2332

Published: Feb. 7, 2019

Abstract Sleep disturbance is the most prominent symptom in depressive patients and was formerly regarded as a main secondary manifestation of depression. However, many longitudinal studies have identified insomnia an independent risk factor for development emerging or recurrent depression among young, middle‐aged older adults. This bidirectional association between sleep has created new perspective that problems are no longer epiphenomenon but predictive prodromal symptom. In this review, we highlight treatment before, during after depression, which probably plays important role improving outcomes preventing recurrence clinical practice, pharmacological therapies, including hypnotics antidepressants, non‐pharmacological therapies typically applied. A better understanding pathophysiological mechanisms can help psychiatrists manage comorbidity.

Language: Английский

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Advancing social connection as a public health priority in the United States.

American Psychologist, Journal Year: 2017, Volume and Issue: 72(6), P. 517 - 530

Published: Sept. 1, 2017

A robust body of scientific evidence has indicated that being embedded in high-quality close relationships and feeling socially connected to the people one's life is associated with decreased risk for all-cause mortality as well a range disease morbidities. Despite mounting magnitude these associations comparable many leading health determinants (that receive significant public resources), government agencies, care providers associations, or private funders have been slow recognize human social either determinant marker manner other priorities. This article evaluates current (on health) according criteria commonly used determining The discusses challenges reducing this area outlines an agenda integrating into (PsycINFO Database Record

Language: Английский

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Inflammation: Depression Fans the Flames and Feasts on the Heat

American Journal of Psychiatry, Journal Year: 2015, Volume and Issue: 172(11), P. 1075 - 1091

Published: Sept. 11, 2015

Depression and inflammation fuel one another. Inflammation plays a key role in depression's pathogenesis for subset of depressed individuals; depression also primes larger cytokine responses to stressors pathogens that do not appear habituate. Accordingly, treatment decisions may be informed by attention questions how (pathways) whom (predispositions) these links exist, which are the focus this article. When combined with predisposing factors (moderators such as childhood adversity obesity), can lead exaggerated or prolonged inflammatory responses. The resulting sickness behaviors (e.g., pain, disturbed sleep), depressive symptoms, negative health poor diet, sedentary lifestyle) act mediating pathways further, unrestrained depression. Depression, adversity, stressors, diet all influence gut microbiome promote intestinal permeability, another pathway enhanced Larger, more frequent, could have mental physical consequences. In clinical practice, provides guide potential targets symptom management signaling responsiveness certain therapeutic strategies. For example, theme across research antagonists, omega-3 fatty acids, celecoxib, exercise is anti-inflammatory interventions substantially greater impact on mood individuals heightened inflammation. Thus, when co-occur, treating them tandem enhance recovery reduce risk recurrence. bidirectional between depression, inflammation, disease suggest effective treatments far-reaching mood, health.

Language: Английский

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