The interplay between diet and the gut microbiome: implications for health and disease

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(11), P. 671 - 686

Published: July 15, 2024

Language: Английский

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Examining the healthy human microbiome concept

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Language: Английский

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Prospects for Leveraging the Microbiota as Medicine for Hypertension

Hypertension, Journal Year: 2024, Volume and Issue: 81(5), P. 951 - 963

Published: April 17, 2024

Language: Английский

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Washed microbiota transplantation effectively improves nutritional status in gastrointestinal disease-related malnourished children

Nutrition, Journal Year: 2025, Volume and Issue: 132, P. 112679 - 112679

Published: Jan. 5, 2025

Language: Английский

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Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 6, 2025

Recurrent respiratory tract infections (RRTIs) are a common condition in pediatrics and significantly impact children's quality of life; however, their pathogenesis contributing factors not yet fully elucidated. Probiotics have recently emerged as promising agents for modulating intestinal microecology gained considerable attention clinical research on preventing treating RRTIs children. This article provides an initial overview the concept, classification, mechanisms underlying probiotics. It emphasizes beneficial effects health by microbial equilibrium, augmenting immune system functionality, attenuating inflammatory responses. Subsequently, we examine existing regarding use probiotics pediatric RRTIs. Numerous trials unequivocally demonstrated that supplementing with can reduce both frequency severity children while also simultaneously decreasing antibiotic usage. However, there ongoing controversies challenges current concerning influence probiotic type, dosage, duration use, other efficacy. Furthermore, variations been observed across different studies. Additionally, it is crucial to further evaluate safety potential long-term side associated In conclusion, propose future directions including conducting more high-quality randomized controlled optimize application strategies alongside treatments considering based age conditions among populations. Finally, summary although exhibit benefits children; additional studies necessary refine ensuring effectiveness.

Language: Английский

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Sequential co-assembly reduces computational resources and errors in metagenome-assembled genomes

Cell Reports Methods, Journal Year: 2025, Volume and Issue: unknown, P. 101005 - 101005

Published: March 1, 2025

Language: Английский

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Integrative genomic reconstruction of carbohydrate utilization networks in bifidobacteria: global trends, local variability, and dietary adaptation

Published: July 7, 2024

Bifidobacteria are among the earliest colonizers of human gut, conferring numerous health benefits. While multiple Bifidobacterium strains used as probiotics, accumulating evidence suggests that individual responses to probiotic supplementation may vary, likely due a variety factors, including strain type(s), gut community composition, dietary habits consumer, and other health/lifestyle conditions. Given saccharolytic nature bifidobacteria, carbohydrate composition diet is one primary factors dictating colonization efficiency strains. Therefore, comprehensive understanding bifidobacterial glycan metabolism at level necessary rationally design or synbiotic formulations combine bacterial with glycans match their nutrient preferences. In this study, we systematically reconstructed 66 pathways involved in utilization mono-, di-, oligo-, polysaccharides by analyzing representation 565 curated metabolic functional roles (catabolic enzymes, transporters, transcriptional regulators) 2973 non-redundant cultured isolates metagenome-assembled genomes (MAGs). Our analysis uncovered substantial heterogeneity predicted capabilities species revealed presence yet undescribed phenotypically distinct subspecies-level clade within longum species. We also identified Bangladeshi harboring unique gene clusters tentatively implicated breakdown xyloglucan milk oligosaccharides. Predicted phenotypes were experimentally characterized validated. large-scale genomic considerably expands knowledge bifidobacteria provides foundation for designing single- multi-strain given well combinations matched preferred substrates.

Language: Английский

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Unlocking the potential for microbiome‐based therapeutics to address the sustainable development goal of good health and wellbeing

Microbial Biotechnology, Journal Year: 2024, Volume and Issue: 17(11)

Published: Nov. 1, 2024

Abstract Recent years have witnessed major advances and an ever‐growing list of healthcare applications for microbiome‐based therapeutics. However, these disproportionately targeted diseases common in high‐income countries (HICs). Within low‐ to middle‐income (LMIC), opportunities therapeutics include sexual health epidemics, maternal health, early life mortality, malnutrition, vaccine response infectious diseases. In this review we detail the that been achieved areas identify where further work is required. Current efforts characterise microbiomes from LMICs will aid targeting optimisation preventative strategies specifically suited unmet needs within populations. Once achieved, disease treatment improved efficacy through prevention vector control can be effectively addressed using probiotics live biotherapeutics. Together potential increase individual overcome logistical challenges reduce overall medical, individual, societal economic costs.

Language: Английский

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Establishing human microbial observatory programs in low‐ and middle‐income countries

Annals of the New York Academy of Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Abstract Studies of the human microbiome are progressing rapidly but have largely focused on populations living in high‐income countries. With increasing evidence that contributes to pathogenesis diseases affect infants, children, and adults low‐ middle‐income countries (LMICs), with profound rapid ongoing changes occurring our lifestyles biosphere, understanding origins developing microbiome‐directed therapeutics for treating a number global health challenges requires development programs studying microbial ecology LMICs. Here, we discuss how establishment long‐term observatory selected LMICs could provide one timely approach.

Language: Английский

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Interplay Between Helminth Infections, Malnutrition, and Gut Microbiota in Children and Mothers from Pemba, Tanzania: Potential of Microbiota-Directed Interventions

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4023 - 4023

Published: Nov. 24, 2024

Despite efforts within the framework of Sustainable Development Goal to end malnutrition by 2030, and soil-transmitted helminth infections persist in sub-Saharan Africa. A significant barrier success is inadequate understanding effective intervention methods. Most research on gut microbiota's role health has been conducted developed countries, leaving a critical gap knowledge regarding low-income populations. This study addresses this expanding microbiota underprivileged populations help tackle these public challenges.

Language: Английский

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