Circadian Clock Control of Liver Metabolic Functions

Gastroenterology, Journal Year: 2015, Volume and Issue: 150(3), P. 574 - 580

Published: Dec. 2, 2015

Language: Английский

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Sleep Irregularity and Risk of Cardiovascular Events

Journal of the American College of Cardiology, Journal Year: 2020, Volume and Issue: 75(9), P. 991 - 999

Published: March 1, 2020

Language: Английский

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Circadian disruption: What do we actually mean?

European Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 51(1), P. 531 - 550

Published: Nov. 7, 2018

The circadian system regulates physiology and behavior. Acute challenges to the system, such as those experienced when traveling across time zones, will eventually result in re-synchronization local environmental cues, but this is oftentimes accompanied by adverse short-term consequences. When are chronically, adaptation may not be achieved, for example case of rotating night shift workers. transient chronic disturbance most frequently referred "circadian disruption", many other terms have been proposed used refer similar situations. It now beyond doubt that contributes health disease, emphasizing need clear terminology describing their goal review provide an overview describe disruption discuss quantifications experimental observational settings with a focus on human research, highlight limitations currently available tools. For research advance translational science, clear, operationalizable, scalable key, they enable improved assessment reproducibility results, ideally ranging from mechanistic settings, including animal large-scale randomized clinical trials.

Language: Английский

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Associations between chronotype, morbidity and mortality in the UK Biobank cohort

Chronobiology International, Journal Year: 2018, Volume and Issue: unknown, P. 1 - 9

Published: April 11, 2018

Later chronotype (i.e. evening preference) and later timing of sleep have been associated with greater morbidity, including higher rates metabolic dysfunction cardiovascular disease (CVD). However, no one has examined whether is mortality risk to date. Our objective was test the hypothesis that being an type increased in a large cohort study, UK Biobank. analysis included 433 268 adults aged 38-73 at time enrolment average 6.5-year follow-up. The primary exposure chronotype, as assessed through single self-reported question-defining participants definite morning types, moderate types or types. outcomes were all-cause due CVD. Prevalent also compared among groups. Analyses adjusted for age, sex, ethnicity, smoking, body mass index, duration, socioeconomic status comorbidities. Greater eveningness, particularly type, significantly prevalence all Comparing associations strongest psychological disorders (OR 1.94, 95% CI 1.86-2.02, p = < 0.001), followed by diabetes 1.30, 1.24-1.36, neurological 1.25, 1.20-1.30, gastrointestinal/abdominal 1.23, 1.19-1.27, 0.001) respiratory 1.22, 1.18-1.26, 0.001). total number deaths 10 534, out which 2127 based on ordinal variable, small (HR 1.02, 1.004-1.05, 0.017) CVD 1.04, 1.00-1.09, 0.06). Compared had 1.10, 1.02-1.18, 0.012). This first report consistent previous reports levels cardiometabolic factors this group. Mortality may be behavioural, physiological factors, many attributable chronic misalignment between internal externally imposed work social activities. These findings suggest need researching possible interventions aimed either modifying circadian rhythms individuals allowing working hour flexibility.

Language: Английский

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Circadian disruption and human health

Journal of Clinical Investigation, Journal Year: 2021, Volume and Issue: 131(19)

Published: Sept. 30, 2021

Circadian disruption is pervasive and can occur at multiple organizational levels, contributing to poor health outcomes individual population levels. Evidence points a bidirectional relationship, in that circadian increases disease severity many diseases disrupt rhythms. Importantly, increase the risk for expression development of neurologic, psychiatric, cardiometabolic, immune disorders. Thus, harnessing rich findings from preclinical translational research biology enhance via circadian-based approaches represents unique opportunity personalized/precision medicine overall societal well-being. In this Review, we discuss implications human using bench-to-bedside approach. science applied clinical population-based Given broad regulation health, Review focuses its discussion on selected examples metabolic, cardiovascular, allergic, immunologic disorders highlight interrelatedness between potential interventions, such as bright light therapy exogenous melatonin, well chronotherapy improve and/or modify outcomes.

Language: Английский

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Sleep timing, sleep consistency, and health in adults: a systematic review

Applied Physiology Nutrition and Metabolism, Journal Year: 2020, Volume and Issue: 45(10 (Suppl. 2)), P. S232 - S247

Published: Oct. 1, 2020

The objective of this systematic review was to examine the associations between sleep timing (e.g., bedtime/wake-up time, midpoint sleep), consistency/regularity intra-individual variability in duration, social jetlag, catch-up and health outcomes adults aged 18 years older. Four electronic databases were searched December 2018 for articles published previous 10 years. Fourteen examined. A total 41 articles, including 92 340 unique participants from 14 countries, met inclusion criteria. Sleep assessed objectively 37% studies subjectively 63% studies. Findings suggest that later greater generally associated with adverse outcomes. However, because most reported linear associations, it not possible identify thresholds “late timing” or “large variability”. In addition, jetlag outcomes, while weekend better quality evidence ranged “very low” “moderate” across study designs using GRADE. conclusion, available supports earlier regularity patterns consistent bedtimes wake-up times are favourably health. (PROSPERO registration no.: CRD42019119534.) Novelty This is first influence consistency on Later both adults. Regularity should be encouraged.

Language: Английский

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Potential Role for the Gut Microbiota in Modulating Host Circadian Rhythms and Metabolic Health

Microorganisms, Journal Year: 2019, Volume and Issue: 7(2), P. 41 - 41

Published: Jan. 31, 2019

This article reviews the current evidence associating gut microbiota with factors that impact host circadian-metabolic axis, such as light/dark cycles, sleep/wake diet, and eating patterns. We examine how bacteria possess their own daily rhythmicity in terms of composition, localization to intestinal niches, functions. review modulate rhythms via microbial metabolites butyrate, polyphenolic derivatives, vitamins, amines. Lifestyle stressors altered sleep patterns may disturb circadian system also influence microbiome. The consequent disruptions microbiota-mediated functions decreased conjugation bile acids or increased production hydrogen sulfide resultant turn affect substrate oxidation energy regulation host. Thus, disturbances microbiome at least partially contribute an risk obesity metabolic syndrome associated insufficient misalignment. Good a healthy diet appear be essential for maintaining balance. Manipulating abundance activity therefore hold promise chrononutrition-based approach consolidate homeorhesis.

Language: Английский

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The Association between Social Jetlag, the Metabolic Syndrome, and Type 2 Diabetes Mellitus in the General Population: The New Hoorn Study

Journal of Biological Rhythms, Journal Year: 2017, Volume and Issue: 32(4), P. 359 - 368

Published: June 20, 2017

Only a few studies have investigated the metabolic consequences of social jetlag. Therefore, we examined association jetlag with syndrome and type 2 diabetes mellitus in population-based cohort. We used cross-sectional data from New Hoorn Study cohort ( n = 1585, 47% men, age 60.8 ± 6 years). Social was calculated as difference midpoint sleep (in hours) between weekdays weekend days. Poisson linear regression models were to study associations, regarded possible effect modifier. adjusted for sex, employment status, education, smoking, physical activity, duration, body mass index. In total population, only observed an syndrome, prevalence ratios educational levels 1.64 (95% CI 1.1-2.4), participants >2 h jetlag, compared <1 However, interaction median (<61 older (≥61 years), no significant associations or prediabetes. younger group 1.29 0.9-1.9) 2.13 1.3-3.4) 1.39 1.1-1.9) 1.75 1.2-2.5) diabetes/prediabetes, 1-2 conclusion, our cohort, associated 2-fold increased risk especially years) participants.

Language: Английский

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Biological Rhythm and Chronotype: New Perspectives in Health

Biomolecules, Journal Year: 2021, Volume and Issue: 11(4), P. 487 - 487

Published: March 24, 2021

The circadian rhythm plays a fundamental role in regulating biological functions, including sleep-wake preference, body temperature, hormonal secretion, food intake, and cognitive physical performance. Alterations can lead to chronic disease impaired sleep. rhythmicity human beings is represented by complex phenotype. Indeed, over 24-h period, person's preferred time be more active or sleep expressed the concept of morningness-eveningness. Three chronotypes are distinguished: Morning, Neither, Evening-types. Interindividual differences need considered reduce negative effects disruptions on health. In present review, we examine bi-directional influences rest-activity cycle pathologies disorders. We analyze main characteristics three chronotypes.

Language: Английский

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Feeding Rhythms and the Circadian Regulation of Metabolism

Frontiers in Nutrition, Journal Year: 2020, Volume and Issue: 7

Published: April 17, 2020

The molecular circadian clock regulates metabolic processes within the cell, and alignment of these clocks between tissues is essential for maintenance homeostasis. possibility misalignment arises from differential responsiveness to environmental cues that synchronize (zeitgebers). Although light dominant cue master suprachiasmatic nucleus, many other are sensitive feeding fasting. When rhythms behaviour altered, example by shift work or constant availability highly palatable foods, strong feedback sent peripheral clocks. Varying degrees phase can cause systemic processes. Moreover, when there a endogenous in physiology inputs, such as during inactive phase, body's ability maintain homeostasis impaired. loss coordination organism environment, well internal tissues, produce cardiometabolic disease consequence. aim this review synthesize on mechanisms effects misalignment. timing food intake highlighted powerful with potential destroy restore synchrony metabolism.

Language: Английский

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