Antibiotic resistance in the environment

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 20(5), P. 257 - 269

Published: Nov. 4, 2021

Language: Английский

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Review of antibiotic resistance in China and its environment

Environment International, Journal Year: 2017, Volume and Issue: 110, P. 160 - 172

Published: Oct. 27, 2017

Language: Английский

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Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: A review

Environmental Research, Journal Year: 2018, Volume and Issue: 169, P. 483 - 493

Published: Nov. 26, 2018

The extensive use of antibiotics leading to the rapid spread antibiotic resistance poses high health risks humans, but date there is still lack a quantitative model properly assess risks. Concerns over risk residues in environment are mainly (1) potential hazard ingested altering human microbiome and promoting emergence selection for bacteria inhabiting body, (2) creating pressure on environmental reservoirs environment. We provide holistic view assessment associated with contrast that resistant discuss main knowledge gaps future research should be prioritized achieve assessment. examined summarized available data information four core elements environment: identification, exposure assessment, dose-response characterization. required characterize severely limited. needs have been identified enable better assessments establishment standardized monitoring guide environment, derivation relationship between levels pathogenic antibiotic-resistance development different settings, (3) various infection diseases. After identification key determinant parameters, we propose conceptual framework A was provided.

Language: Английский

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Continental-scale pollution of estuaries with antibiotic resistance genes

Nature Microbiology, Journal Year: 2017, Volume and Issue: 2(4)

Published: Jan. 30, 2017

Language: Английский

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Antibiotic Pollution in the Environment: From Microbial Ecology to Public Policy

Microorganisms, Journal Year: 2019, Volume and Issue: 7(6), P. 180 - 180

Published: June 22, 2019

The ability to fight bacterial infections with antibiotics has been a longstanding cornerstone of modern medicine. However, wide-spread overuse and misuse led unintended consequences, which in turn require large-scale changes policy for mitigation. In this review, we address two broad classes corollaries misuse. Firstly, discuss the spread antibiotic resistance from hotspots evolution environment, special concerns given potential vectors transmission. Secondly, outline effects pollution independent on natural microbial populations, as well invertebrates vertebrates. We close an overview current regional policies tasked curbing areas such are still under development.

Language: Английский

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Antibiotic Resistome and Its Association with Bacterial Communities during Sewage Sludge Composting

Environmental Science & Technology, Journal Year: 2015, Volume and Issue: 49(12), P. 7356 - 7363

Published: May 27, 2015

Composting is widely used for recycling of urban sewage sludge to improve soil properties, which represents a potential pathway spreading antibiotic resistant bacteria and genes soils. However, the dynamics resistance (ARGs) underlying mechanisms during composting were not fully explored. Here, we high-throughput quantitative PCR 16S rRNA gene based illumina sequencing investigate ARGs bacterial communities lab-scale in-vessel sludge. A total 156 unique mobile genetic elements (MGEs) detected encoding almost all major classes antibiotics. with significantly increased abundance diversity, distinct patterns, enriched composting. Marked shifts in community structures compositions observed composting, Actinobacteria being dominant phylum at late phase The large proportion may partially explain increase patterns correlated structures, suggesting that dynamic was strongly affected by phylogenetic These results imply direct application compost on field lead spread abundant

Language: Английский

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Co-occurrence of resistance genes to antibiotics, biocides and metals reveals novel insights into their co-selection potential

BMC Genomics, Journal Year: 2015, Volume and Issue: 16(1)

Published: Nov. 17, 2015

Antibacterial biocides and metals can co-select for antibiotic resistance when bacteria harbour or tolerance genes towards both types of compounds. Despite numerous case studies, systematic quantitative data on co-occurrence such plasmids chromosomes is lacking, as knowledge environments bacterial taxa that tend to carry This effectively prevents identification risk scenarios. Therefore, we aimed identify general patterns which biocide/metal (BMRGs) (ARGs) occur together. We also quantify in different taxa, investigate what extent carrying are conjugative and/or toxin-antitoxin systems.Co-occurrence were derived from publicly available, fully sequenced genomes (n = 2522) 4582). The only BMRGs commonly co-occurring with ARGs mercury the qacE∆1 gene provides low-level quaternary ammonium Novel connections between cadmium/zinc macrolide/aminoglycoside uncovered. Several clinically important particularly prone ARGs. Bacteria more often carried compared without (p < 0.0001). found 86 % genomes, co-occurred 17 cases. In contrast, co-occurrences rare all external (<0.7 %) but common those human domestic animal origin (5 7 %, respectively). Finally, likely be 0.0001) systems than genes.This first large-scale compounds, particular concern co-selection against antibiotics, metals. Genetic suggest provide limited opportunities promote horizontal transfer through co-selection, whereas ample possibilities exist indirect selection via chromosomal BMRGs. Taken together, improve our understanding potential biocides, thereby guidance risk-reducing actions.

Language: Английский

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A review of the influence of treatment strategies on antibiotic resistant bacteria and antibiotic resistance genes

Chemosphere, Journal Year: 2016, Volume and Issue: 150, P. 702 - 714

Published: Jan. 14, 2016

Language: Английский

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Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Jan. 2, 2019

Discharge of treated sewage leads to release antibiotic resistant bacteria, resistance genes and residues the environment. However, it is unclear whether increased abundance in sewage-impacted environments due on-site selection pressure by residual antibiotics, or simply a result fecal contamination with bacteria. Here we analyze relative gene accompanying extent pollution publicly available metagenomic data, using crAssphage sequences as marker human (crAssphage bacteriophage that exceptionally abundant in, specific to, feces). We find presence can largely be explained pollution, no clear signs environment, exception polluted very high levels antibiotics from manufacturing, where evident. Our results demonstrate necessity take into account avoid making erroneous assumptions regarding environmental resistance.

Language: Английский

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Environmental Factors Support the Formation of Specific Bacterial Assemblages on Microplastics

Frontiers in Microbiology, Journal Year: 2018, Volume and Issue: 8

Published: Jan. 19, 2018

While the global distribution of microplastics (MP) in marine environment is currently being critically evaluated, potential role MP as a vector for distinct microbial assemblages or even pathogenic bacteria hardly understood. To gain deeper understanding, we investigated how different situ conditions contribute to composition and specificity MP-associated bacterial communities relation on natural particles. Polystyrene (PS), polyethylene (PE), wooden pellets were incubated 2 weeks along an environmental gradient, ranging from (coastal Baltic Sea) freshwater (waste water treatment plant, WWTP) conditions. The associated well applying high-throughput 16S rRNA gene sequencing. Our setup allowed first time determine MP-dependent -independent assemblage factors subject one system. Most importantly, plastic-specific found develop solely under certain conditions, such lower nutrient concentration higher salinity, while genus Erythrobacter, known ability utilize polycyclic aromatic hydrocarbons (PAH), was specifically across broader section gradient. We discovered no enrichment pathogens PE PS; however, abundant colonization WWTP by commonly with antibiotic resistance suggests possible hotspot horizontal transfer. Taken together, our study clarifies that surrounding prevailingly shapes biofilm communities, but MP-specific exist. These findings point ecological significance specific MP-promoted populations aquatic environments particularly plastic accumulation zones.

Language: Английский

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