ACS Infectious Diseases,
Journal Year:
2023,
Volume and Issue:
9(7), P. 1283 - 1302
Published: June 22, 2023
The
emergence
of
antibiotic-resistant
bacterial
strains
is
a
source
public
health
concern
across
the
globe.
As
discovery
new
conventional
antibiotics
has
stalled
significantly
over
past
decade,
there
an
urgency
to
develop
novel
approaches
address
drug
resistance
in
infectious
diseases.
use
CRISPR-Cas-based
system
for
precise
elimination
targeted
populations
holds
promise
as
innovative
approach
antimicrobial
agent
design.
CRISPR-Cas
targeting
celebrated
its
high
versatility
and
specificity,
offering
excellent
opportunity
fight
antibiotic
pathogens
by
selectively
inactivating
genes
involved
resistance,
biofilm
formation,
pathogenicity,
virulence,
or
viability.
strategy
can
enact
effects
two
approaches:
inactivation
chromosomal
curing
plasmids
encoding
resistance.
In
this
Review,
we
provide
overview
main
systems
utilized
creation
these
antimicrobials,
well
highlighting
promising
studies
field.
We
also
offer
detailed
discussion
about
most
commonly
used
mechanisms
delivery:
bacteriophages,
nanoparticles,
conjugative
plasmids.
Lastly,
possible
interference
that
should
be
considered
during
intelligent
design
approaches.
Environmental Science & Technology,
Journal Year:
2022,
Volume and Issue:
56(13), P. 9149 - 9160
Published: June 22, 2022
Antimicrobial
resistance
(AMR)
is
a
grand
societal
challenge
with
important
dimensions
in
the
water
environment
that
contribute
to
its
evolution
and
spread.
Environmental
monitoring
could
provide
vital
information
for
mitigating
spread
of
AMR;
this
includes
assessing
antibiotic
genes
(ARGs)
circulating
among
human
populations,
identifying
key
hotspots
dissemination
resistance,
informing
epidemiological
health
risk
assessment
models,
quantifying
removal
efficiencies
by
domestic
wastewater
infrastructure.
However,
standardized
methods
AMR
will
be
producing
comparable
data
sets
needed
address
such
questions.
Here
we
sought
establish
scientific
consensus
on
framework
standardization,
evaluating
state
science
practice
wastewater,
recycled
water,
surface
through
literature
review,
survey,
workshop
leveraging
expertise
academic,
governmental,
consulting,
utility
professionals.
Antibiotics,
Journal Year:
2022,
Volume and Issue:
11(10), P. 1417 - 1417
Published: Oct. 16, 2022
The
growing
emergence
of
antimicrobial
resistance
represents
a
global
problem
that
not
only
influences
healthcare
systems
but
also
has
grave
implications
for
political
and
economic
processes.
As
the
discovery
novel
agents
is
lagging,
one
solutions
innovative
therapeutic
options
would
expand
our
armamentarium
against
this
hazard.
Compounds
interest
in
many
such
studies
are
peptides
(AMPs),
which
actually
represent
host’s
first
line
defense
pathogens
involved
innate
immunity.
They
have
broad
range
activity
Gram-negative
Gram-positive
bacteria,
fungi,
viruses,
with
specific
mechanisms
action
utilized
by
different
AMPs.
Coupled
lower
propensity
development,
it
becoming
clear
AMPs
can
be
seen
as
emerging
very
promising
candidates
more
pervasive
usage
treatment
infectious
diseases.
However,
their
use
quotidian
clinical
practice
without
challenges.
In
review,
we
aimed
to
summarize
state-of-the-art
evidence
on
structure
AMPs,
well
provide
detailed
information
activity.
We
present
contemporary
trials
application
highlight
beyond
diseases
potential
challenges
may
arise
increasing
availability.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Aug. 28, 2023
In
recent
ages,
green
nanotechnology
has
gained
attraction
in
the
synthesis
of
metallic
nanoparticles
due
to
their
cost-effectiveness,
simple
preparation
steps,
and
environmentally-friendly.
present
study,
copper
oxide
(CuO
NPs)
were
prepared
using
Parthenium
hysterophorus
whole
plant
aqueous
extract
as
a
reducing,
stabilizing,
capping
agent.
The
CuO
NPs
characterized
via
UV-Vis
Spectroscopy,
Fourier
Transform
Infrared
Spectroscopy
(FTIR),
powder
X-Ray
Diffraction
(XRD),
Scanning
Electron
Microscopy
(SEM),
Transmission
(TEM),
Dynamic
Light
Scattering
(DLS).
spectra
showed
surface
plasmonic
resonance
band
occur
at
340
nm.
FTIR
analysis
revealed
presence
secondary
metabolites
on
NPs,
with
characteristic
Cu-O
stretching
being
identified
522
cm
