Circadian rhythm and disease: Relationship, new insights, and future perspectives

Journal of Cellular Physiology, Journal Year: 2022, Volume and Issue: 237(8), P. 3239 - 3256

Published: June 13, 2022

Abstract The circadian system is responsible for internal functions and regulation of the organism according to environmental cues (zeitgebers). Circadian rhythm dysregulation or chronodisruption has been associated with several diseases, from mental autoimmune life quality change. Following this, some therapies have developed correct misalignments, such as light therapy chronobiotics. In this manuscript, we describe circadian‐related diseases so far investigated, studies reporting relevant data on topic, evidencing relationship, are included. Despite actual limitations in published work, there clear evidence correlation between disease origin/development, and, way, clock‐related emerge great progress clinical field. Future improvements interventions can lead development successful chronotherapy strategies, deeply contributing enhanced therapeutic outcomes.

Language: Английский

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The circadian system, sleep, and the health/disease balance: a conceptual review

Journal of Sleep Research, Journal Year: 2022, Volume and Issue: 31(4)

Published: June 7, 2022

Summary The field of “circadian medicine” is a recent addition to chronobiology and sleep research efforts. It represents logical step arising from the increasing insights into circadian system its interactions with life in urbanised societies; applying these health/disease balance at home medical practice (outpatient) clinic (inpatient). Despite fast expansion proliferating efforts, medicine lacks formal framework categorise many observations describing among system, sleep, balance. A good allows us then assign them one or more components hypothesised interactions. Such assignments can lead experiments that document causal (rather than correlational) relationships move discovering mechanisms. This review details such proposed for will hopefully trigger discussion our colleagues, so be improved expanded. As basis medicine, we define health” how it links general health. We put context literature examples six domains balance: fertility, cancer, immune mental health, cardiovascular, metabolism.

Language: Английский

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Adaptive immunity, chronic inflammation and the clock

Seminars in Immunopathology, Journal Year: 2022, Volume and Issue: 44(2), P. 209 - 224

Published: March 1, 2022

Abstract The adaptive arm of the immune system facilitates recognition specific foreign pathogens and, via action T and B lymphocytes, induces a fine-tuned response to target pathogen develop immunological memory. functionality exhibits daily 24-h variation both in homeostatic processes (such as lymphocyte trafficking development subsets) responses challenge. Here, we discuss how circadian clock exerts influence over function system, considering roles cell intrinsic clockwork machinery extrinsic rhythmic signals. Inappropriate or misguided actions can lead autoimmune diseases such rheumatoid arthritis, ulcerative colitis multiple sclerosis. Growing evidence indicates that disturbance has negative impact on progression these chronic inflammatory examine current understanding clock-immune interactions setting conditions. A greater appreciation control immunity will facilitate further mechanisms driving disease states drive improvements diagnosis treatment diseases.

Language: Английский

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Circadian molecular clock disruption in chronic pulmonary diseases

Trends in Molecular Medicine, Journal Year: 2022, Volume and Issue: 28(6), P. 513 - 527

Published: May 1, 2022

Language: Английский

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Lung epithelial cell–derived C3 protects against pneumonia-induced lung injury

Science Immunology, Journal Year: 2023, Volume and Issue: 8(80)

Published: Feb. 3, 2023

The complement component C3 is a fundamental plasma protein for host defense, produced largely by the liver. However, recent work has demonstrated critical importance of tissue-specific expression in cell survival. Here, we analyzed effects local versus peripheral sources model acute bacterial pneumonia induced Pseudomonas aeruginosa . Whereas mice with global deficiency had severe pneumonia-induced lung injury, those deficient only liver-derived remained protected, comparable to wild-type mice. Human transcriptome analysis showed that secretory epithelial cells, such as club express high levels mRNA. Mice tamoxifen-induced gene ablation from cells worse pulmonary injury compared similarly treated controls, despite maintaining normal circulating levels. Last, both mouse and cultured primary human airway stress-induced death associated parallels seen Factor B rather than C3a receptor deficiency. Moreover, C3-mediated reduction requires alternative pathway B. Thus, our findings suggest reliant on locally derived protects mucosal barrier.

Language: Английский

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Biological rhythms in COVID-19 vaccine effectiveness in an observational cohort study of 1.5 million patients

Journal of Clinical Investigation, Journal Year: 2023, Volume and Issue: 133(11)

Published: April 13, 2023

BACKGROUND. Circadian rhythms are evident in basic immune processes, but it is unclear if exist clinical endpoints like vaccine protection. Here, we examined associations between COVID-19 vaccination timing and effectiveness.

Language: Английский

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Circadian rhythm disruption in critically ill patients

Acta Physiologica, Journal Year: 2023, Volume and Issue: 238(1)

Published: March 14, 2023

Abstract Patients admitted to the intensive care unit (ICU) are in need of continuous organ replacement strategies and specialized care, for example because neurological dysfunction, cardio‐pulmonary instability, liver or kidney failure, trauma, hemorrhagic septic shock even preterm birth. The 24‐h nursing interventions provided critically ill patients significantly limit resting and/or recovery phases. Consecutively, patient's endogenous circadian rhythms misaligned disrupted, which turn may interfere with their critical condition. A more thorough understanding complex interactions effectors tissue‐specific molecular clocks could therefore serve as potential means enhancing personalized treatment patients, conceivably restoring network thus accelerating physical neurocognitive recovery. This review addresses overarching issue how affected disturbed newborns adults ICU, whether conflicting external environmental cues ICU environment further promote disruption severity illness. We direct special attention influence cell‐type specific on dysfunctions such brain pneumonia‐ ventilator‐associated lung inflammation, cardiovascular shock. Finally, we address rhythm stabilization enhance accelerate clinical

Language: Английский

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Circadian metabolic adaptations to infections

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 380(1918)

Published: Jan. 23, 2025

Circadian clocks are biological oscillators that evolved to coordinate rhythms in behaviour and physiology around the 24-hour day. In mammalian tissues, circadian metabolism highly intertwined. The clock machinery controls rhythmic levels of circulating hormones metabolites, as well rate-limiting enzymes catalysing biosynthesis or degradation macromolecules metabolic such control being exerted both at transcriptional post-transcriptional level. During infections, major adaptation occurs hosts, level single immune cell whole organism. Under these circumstances, needs host intersect with those two other players: pathogen microbiota. These three components cooperate compete meet their own demands across 24 hours. Here, we review findings describing regulation response infection, adaptations occurring during host–microbiota–pathogen interactions how can influence and, ultimately, its survival. This article is part Theo Murphy meeting issue ‘Circadian infection immunity’.

Language: Английский

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Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection

European Respiratory Journal, Journal Year: 2020, Volume and Issue: 55(6), P. 2001023 - 2001023

Published: April 29, 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the aetiological agent of pandemic disease 2019 (COVID-19), is a newly found member Coronaviridae family, and closely related to, albeit with important differences from, SARS-CoV [1]. It enters human cells through binding surface spike (S) glycoprotein angiotensin-converting enzyme (ACE2) [2–4]. The distal S1 subunit S protein responsible for receptor binding, while transmembrane S2 mediates fusion between viral envelope target cell membrane following proteolytic cleavage by specific cellular enzymes such as serine protease priming [5]. As it likely that expression levels ACE2 affect efficiency virus attachment entry, well severity [6], interactions may directly cause lung injury [7], be potential therapeutic preventative interventions [8]. Circadian deregulation poor or insufficient sleep facilitate COVID-19 infection

Language: Английский

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The Genetics and Genomics of Asthma

Annual Review of Genomics and Human Genetics, Journal Year: 2018, Volume and Issue: 19(1), P. 223 - 246

Published: Aug. 31, 2018

Asthma is a common, clinically heterogeneous disease with strong evidence of heritability. Progress in defining the genetic underpinnings asthma, however, has been slow and hampered by issues inconsistency. Recent advances tools available for analysis—assaying transcription, sequence variation, epigenetic marks on genome-wide scale—have substantially altered this landscape. Applications such approaches are consistent heterogeneity at level causation specify patterns commonality wide range alternative traits. Looking beyond individual as unit study, technology have also fostered comprehensive analysis human microbiome its varied roles health disease. In article, we consider implications these technological our current understanding genetics genomics asthma.

Language: Английский

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