Science Advances,
Journal Year:
2019,
Volume and Issue:
5(2)
Published: Feb. 1, 2019
Schizophrenia
(SCZ)
is
a
devastating
mental
disorder
with
poorly
defined
underlying
molecular
mechanisms.
The
gut
microbiome
can
modulate
brain
function
and
behaviors
through
the
microbiota-gut-brain
axis.
Here,
we
found
that
unmedicated
medicated
patients
SCZ
had
decreased
α-diversity
index
marked
disturbances
of
microbial
composition
versus
healthy
controls
(HCs).
Several
unique
bacterial
taxa
(e.g.,
Veillonellaceae
Lachnospiraceae)
were
associated
severity.
A
specific
panel
(Aerococcaceae,
Bifidobacteriaceae,
Brucellaceae,
Pasteurellaceae,
Rikenellaceae)
enabled
discriminating
from
HCs
0.769
area
under
curve.
Compared
to
HCs,
germ-free
mice
receiving
fecal
transplants
lower
glutamate
higher
glutamine
GABA
in
hippocampus
displayed
SCZ-relevant
similar
other
mouse
models
involving
glutamatergic
hypofunction.
Together,
our
findings
suggest
itself
alter
neurochemistry
neurologic
ways
may
be
relevant
pathology.
Journal of Alzheimer s Disease,
Journal Year:
2018,
Volume and Issue:
63(4), P. 1337 - 1346
Published: May 11, 2018
Previous
studies
suggest
that
gut
microbiota
is
associated
with
neuropsychiatric
disorders,
such
as
Parkinson's
disease,
amyotrophic
lateral
sclerosis,
and
depression.
However,
whether
the
composition
diversity
of
altered
in
patients
Alzheimer's
disease
(AD)
remains
large
ly
unknown.
In
present
study,
we
collected
fecal
samples
from
43
AD
age-
gender-matched
cognitively
normal
controls.
16S
ribosomal
RNA
sequencing
technique
was
used
to
analyze
feces.
The
different
between
two
groups.
Several
bacteria
taxa
were
those
controls
at
taxonomic
levels,
Bacteroides,
Actinobacteria,
Ruminococcus,
Lachnospiraceae,
Selenomonadales.
Our
findings
may
be
involved
pathogenesis
AD.
International Journal of Molecular Sciences,
Journal Year:
2017,
Volume and Issue:
18(12), P. 2645 - 2645
Published: Dec. 7, 2017
Long-term
dietary
habits
play
a
crucial
role
in
creating
host-specific
gut
microbiota
community
humans.
Despite
the
many
publications
about
effects
of
carbohydrates
(prebiotic
fibers),
impact
fats,
such
as
omega-3
polyunsaturated
fatty
acids
(PUFAs),
on
is
less
well
defined.
The
few
studies
completed
adults
showed
some
common
changes
after
PUFA
supplementation.
In
particular,
decrease
Faecalibacterium,
often
associated
with
an
increase
Bacteroidetes
and
butyrate-producing
bacteria
belonging
to
Lachnospiraceae
family,
has
been
observed.
Coincidentally,
dysbiosis
these
taxa
found
patients
inflammatory
bowel
disease.
Omega-3
PUFAs
can
exert
positive
action
by
reverting
composition
diseases,
production
anti-inflammatory
compounds,
like
short-chain
acids.
addition,
accumulating
evidence
animal
model
indicates
that
interplay
between
microbiota,
acids,
immunity
helps
maintain
intestinal
wall
integrity
interacts
host
immune
cells.
Finally,
human
have
highlighted
ability
influence
gut–brain
axis,
acting
through
composition.
From
findings,
importance
connection
emerges,
encouraging
further
studies.
Science Advances,
Journal Year:
2019,
Volume and Issue:
5(2)
Published: Feb. 1, 2019
Schizophrenia
(SCZ)
is
a
devastating
mental
disorder
with
poorly
defined
underlying
molecular
mechanisms.
The
gut
microbiome
can
modulate
brain
function
and
behaviors
through
the
microbiota-gut-brain
axis.
Here,
we
found
that
unmedicated
medicated
patients
SCZ
had
decreased
α-diversity
index
marked
disturbances
of
microbial
composition
versus
healthy
controls
(HCs).
Several
unique
bacterial
taxa
(e.g.,
Veillonellaceae
Lachnospiraceae)
were
associated
severity.
A
specific
panel
(Aerococcaceae,
Bifidobacteriaceae,
Brucellaceae,
Pasteurellaceae,
Rikenellaceae)
enabled
discriminating
from
HCs
0.769
area
under
curve.
Compared
to
HCs,
germ-free
mice
receiving
fecal
transplants
lower
glutamate
higher
glutamine
GABA
in
hippocampus
displayed
SCZ-relevant
similar
other
mouse
models
involving
glutamatergic
hypofunction.
Together,
our
findings
suggest
itself
alter
neurochemistry
neurologic
ways
may
be
relevant
pathology.
