Cancer nanomedicine for combination cancer immunotherapy

Nature Reviews Materials, Journal Year: 2019, Volume and Issue: 4(6), P. 398 - 414

Published: April 26, 2019

Language: Английский

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Targeted drug delivery strategies for precision medicines

Nature Reviews Materials, Journal Year: 2021, Volume and Issue: 6(4), P. 351 - 370

Published: Feb. 2, 2021

Language: Английский

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Enhancing cancer immunotherapy with nanomedicine

Nature reviews. Immunology, Journal Year: 2020, Volume and Issue: 20(5), P. 321 - 334

Published: Jan. 31, 2020

Language: Английский

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Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 157, P. 142 - 160

Published: Jan. 1, 2020

Language: Английский

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Composition design and medical application of liposomes

European Journal of Medicinal Chemistry, Journal Year: 2019, Volume and Issue: 164, P. 640 - 653

Published: Jan. 9, 2019

Language: Английский

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Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance

Pharmacological Research, Journal Year: 2021, Volume and Issue: 171, P. 105780 - 105780

Published: July 21, 2021

Language: Английский

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Nanotechnology in cancer diagnosis: progress, challenges and opportunities

Journal of Hematology & Oncology, Journal Year: 2019, Volume and Issue: 12(1)

Published: Dec. 1, 2019

Abstract In the fight against cancer, early detection is a key factor for successful treatment. However, of cancer in stage has been hindered by intrinsic limits conventional diagnostic methods. Nanotechnology provides high sensitivity, specificity, and multiplexed measurement capacity therefore investigated extracellular biomarkers cells, as well vivo imaging. This review summarizes latest developments nanotechnology applications diagnosis. addition, challenges translation nanotechnology-based methods into clinical are discussed.

Language: Английский

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Stimuli-Responsive Nano-Architecture Drug-Delivery Systems to Solid Tumor Micromilieu: Past, Present, and Future Perspectives

ACS Nano, Journal Year: 2018, Volume and Issue: 12(11), P. 10636 - 10664

Published: Oct. 17, 2018

The microenvironment characteristics of solid tumors, renowned as barriers that harshly impeded many drug-delivery approaches, were precisely studied, investigated, categorized, divided, and subdivided into a complex diverse barriers. These categories further studied with particular perspective, which makes all found in solid-tumor micromilieu turn different types stimuli, considered triggers can increase hasten drug-release targeting efficacy. This review gathers data concerning the nature micromilieu. Past research focused on treatment such recent efforts employed for engineering smart nanoarchitectures utilization specified stimuli categories, possibility combining more than one much-greater enhancement, examples approved already translated clinically well obstacles faced by use these nanostructures, and, finally, an overview possible future implementations smart-chemical design more-efficient drug delivery theranostic systems making nanosystems much-higher level specificity penetrability features.

Language: Английский

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Recent Advances in Tumor Targeting via EPR Effect for Cancer Treatment

Journal of Personalized Medicine, Journal Year: 2021, Volume and Issue: 11(6), P. 571 - 571

Published: June 18, 2021

Cancer causes the second-highest rate of death world-wide. A major shortcoming inherent in most anticancer drugs is their lack tumor selectivity. Nanodrugs for cancer therapy administered intravenously escape renal clearance, are unable to penetrate through tight endothelial junctions normal blood vessels and remain at a high level plasma. Over time, concentration nanodrugs builds up tumors due EPR effect, reaching several times higher than that plasma lymphatic drainage. This review will address detail progress prospects tumor-targeting via effect therapy.

Language: Английский

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The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(3), P. 1746 - 1803

Published: Jan. 14, 2021

Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a decade. Classically, scientists have tried improve NM by employing passive or active targeting strategies, making use so-called enhanced permeability and retention (EPR) effect. This phenomenon is made possible due leaky tumor vasculature through which NMs can leave bloodstream, traverse gaps in endothelial lining vessels, enter tumor. Recent studies shown that despite many efforts employ EPR effect, this process remains very poor. Furthermore, role effect called into question, where it suggested

Language: Английский

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