Protective and pathogenic functions of macrophage subsets

Nature reviews. Immunology, Journal Year: 2011, Volume and Issue: 11(11), P. 723 - 737

Published: Oct. 14, 2011

Language: Английский

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Role of the Microbiota in Immunity and Inflammation

Cell, Journal Year: 2014, Volume and Issue: 157(1), P. 121 - 141

Published: March 1, 2014

Language: Английский

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Microbial interactions: from networks to models

Nature Reviews Microbiology, Journal Year: 2012, Volume and Issue: 10(8), P. 538 - 550

Published: July 16, 2012

Language: Английский

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Inflammasomes in health and disease

Nature, Journal Year: 2012, Volume and Issue: 481(7381), P. 278 - 286

Published: Jan. 1, 2012

Language: Английский

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Keystone taxa as drivers of microbiome structure and functioning

Nature Reviews Microbiology, Journal Year: 2018, Volume and Issue: 16(9), P. 567 - 576

Published: May 22, 2018

Language: Английский

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Crohn's disease

The Lancet, Journal Year: 2016, Volume and Issue: 389(10080), P. 1741 - 1755

Published: Nov. 30, 2016

Language: Английский

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Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

Physiological Reviews, Journal Year: 2014, Volume and Issue: 94(2), P. 329 - 354

Published: April 1, 2014

Reactive oxygen species (ROS) are generated as by-products of normal cellular metabolic activities. Superoxide dismutase, glutathione peroxidase, and catalase the enzymes involved in protecting cells from damaging effects ROS. ROS produced response to ultraviolet radiation, cigarette smoking, alcohol, nonsteroidal anti-inflammatory drugs, ischemia-reperfusion injury, chronic infections, inflammatory disorders. Disruption homeostasis by redox signaling may result cardiovascular, neurodegenerative diseases cancer. within gastrointestinal (GI) tract, but their roles pathophysiology disease pathogenesis have not been well studied. Despite protective barrier provided mucosa, ingested materials microbial pathogens can induce oxidative injury GI responses involving epithelium immune/inflammatory cells. The various including peptic ulcers, cancers, bowel is part due stress. Unraveling events initiated at level free radicals physiological such stress important better understand develop new therapies manage a variety conditions for which current always sufficient.

Language: Английский

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The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

Proceedings of the National Academy of Sciences, Journal Year: 2014, Volume and Issue: 111(6), P. 2247 - 2252

Published: Jan. 3, 2014

Significance The mammalian intestines contain an enormous number of microorganisms within the lumen. Given constant exposure to these microbes, intestinal immune system has difficult task maintaining tolerance commensal bacteria while remaining responsive potential pathogens. mechanisms by which this balance is achieved are relatively unknown. Here, we identify a bacterial metabolite, n-butyrate, that exerts immunomodulatory effects on macrophages and renders them hyporesponsive commensals reside in colon. Our studies elucidate possible mechanism contributes homeostasis intestines.

Language: Английский

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The keystone-pathogen hypothesis

Nature Reviews Microbiology, Journal Year: 2012, Volume and Issue: 10(10), P. 717 - 725

Published: Sept. 3, 2012

Language: Английский

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Regional specialization within the intestinal immune system

Nature reviews. Immunology, Journal Year: 2014, Volume and Issue: 14(10), P. 667 - 685

Published: Sept. 19, 2014

Language: Английский

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