Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

Cold Spring Harbor Perspectives in Biology, Journal Year: 2014, Volume and Issue: 6(4), P. a018713 - a018713

Published: April 1, 2014

Edward Seto1 and Minoru Yoshida2 1Department of Molecular Oncology, Moffitt Cancer Center Research Institute, Tampa, Florida 33612 2Chemical Genetics Laboratory, RIKEN, Wako, Saitama 351-0198, Japan Correspondence: ed.seto{at}moffitt.org

Language: Английский

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Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

Nature Reviews Drug Discovery, Journal Year: 2014, Volume and Issue: 13(9), P. 673 - 691

Published: Aug. 18, 2014

Language: Английский

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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

Nature Neuroscience, Journal Year: 2014, Volume and Issue: 17(9), P. 1156 - 1163

Published: Aug. 17, 2014

Language: Английский

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Ketone bodies as signaling metabolites

Trends in Endocrinology and Metabolism, Journal Year: 2013, Volume and Issue: 25(1), P. 42 - 52

Published: Oct. 18, 2013

Language: Английский

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The world of protein acetylation

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Journal Year: 2016, Volume and Issue: 1864(10), P. 1372 - 1401

Published: June 14, 2016

Acetylation is one of the major post-translational protein modifications in cell, with manifold effects on level as well metabolome level. The acetyl group, donated by metabolite acetyl-coenzyme A, can be co- or post-translationally attached to either α-amino group N-terminus proteins ε-amino lysine residues. These reactions are catalyzed various N-terminal and acetyltransferases. In case acetylation, reaction enzymatically reversible via tightly regulated metabolism-dependent mechanisms. interplay between acetylation deacetylation crucial for many important cellular processes. recent years, our understanding has increased significantly global proteomics analyses depth functional studies. This review gives a general overview respective acetyltransferases, focuses regulation metabolic processes physiological consequences that come along acetylation.

Language: Английский

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Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Molecular Neurodegeneration, Journal Year: 2020, Volume and Issue: 15(1)

Published: July 16, 2020

Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disorder seen in age-dependent dementia. There currently no effective treatment for AD, which may be attributed part to lack of a clear underlying mechanism. Studies within last few decades provide growing evidence central role amyloid β (Aβ) and tau, as well glial contributions various molecular cellular pathways AD pathogenesis. Herein, we review recent progress with respect Aβ- tau-associated mechanisms, discuss dysfunction emphasis on neuronal receptors that mediate Aβ-induced toxicity. We also other critical factors affect pathogenesis, including genetics, aging, variables related environment, lifestyle habits, describe potential apolipoprotein E (APOE), viral bacterial infection, sleep, microbiota. Although have gained much towards understanding aspects this devastating disorder, greater commitment research mechanism, diagnostics will needed future research.

Language: Английский

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β-Hydroxybutyrate: A Signaling Metabolite

Annual Review of Nutrition, Journal Year: 2017, Volume and Issue: 37(1), P. 51 - 76

Published: Aug. 21, 2017

Various mechanisms in the mammalian body provide resilience against food deprivation and dietary stress. The ketone β-hydroxybutyrate (BHB) is synthesized liver from fatty acids represents an essential carrier of energy to peripheral tissues when supply glucose too low for body's energetic needs, such as during periods prolonged exercise, starvation, or absence carbohydrates. In addition its activity metabolite, BHB increasingly understood have cellular signaling functions. These functions broadly link outside environment epigenetic gene regulation function, their actions may be relevant a variety human diseases well aging.

Language: Английский

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Histone acetylation: molecular mnemonics on the chromatin

Nature reviews. Neuroscience, Journal Year: 2013, Volume and Issue: 14(2), P. 97 - 111

Published: Jan. 17, 2013

Language: Английский

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Epigenetic regulation of ageing: linking environmental inputs to genomic stability

Nature Reviews Molecular Cell Biology, Journal Year: 2015, Volume and Issue: 16(10), P. 593 - 610

Published: Sept. 16, 2015

Language: Английский

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The road to restoring neural circuits for the treatment of Alzheimer's disease

Nature, Journal Year: 2016, Volume and Issue: 539(7628), P. 187 - 196

Published: Nov. 1, 2016

Language: Английский

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