Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction

Neuron, Journal Year: 2013, Volume and Issue: 79(6), P. 1109 - 1122

Published: Sept. 1, 2013

Language: Английский

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Aging and age‐related diseases: from mechanisms to therapeutic strategies

Biogerontology, Journal Year: 2021, Volume and Issue: 22(2), P. 165 - 187

Published: Jan. 27, 2021

Language: Английский

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Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons

Nature Neuroscience, Journal Year: 2013, Volume and Issue: 16(10), P. 1383 - 1391

Published: Sept. 15, 2013

Language: Английский

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Environment and Brain Plasticity: Towards an Endogenous Pharmacotherapy

Physiological Reviews, Journal Year: 2014, Volume and Issue: 94(1), P. 189 - 234

Published: Jan. 1, 2014

Brain plasticity refers to the remarkable property of cerebral neurons change their structure and function in response experience, a fundamental theoretical theme field basic research major focus for neural rehabilitation following brain disease. While much early work on this topic was based deprivation approaches relying sensory experience reduction procedures, advances have been recently obtained using conceptually opposite paradigm environmental enrichment, whereby an enhanced stimulation is provided at multiple cognitive, sensory, social, motor levels. In survey, we aim review past recent concerning influence exerted by environment processes, with special emphasis underlying cellular molecular mechanisms starting from experimental animal models move highly relevant performed humans. We will initiate introducing concept describing classic paradigmatic examples illustrate how changes level neuronal properties can ultimately affect direct key perceptual behavioral outputs. Then, describe effects elicited stressful conditions, maternal care, preweaning enrichment central nervous system development, separate section focusing neurodevelopmental disorders. A specific dedicated striking ability physical exercise empower adult plasticity. Finally, analyze last ever-increasing available knowledge enriched living conditions physiological pathological aging processes.

Language: Английский

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Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder

Pharmacological Reviews, Journal Year: 2013, Volume and Issue: 65(1), P. 105 - 142

Published: Jan. 1, 2013

The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar disorder (BD), a severe mental illness arising from complex interactions between genes environment that drive deficits in cellular plasticity resiliency. therapeutic potential of these drugs other central nervous system diseases is also gaining support. This article reviews the various mechanisms action VPA gleaned animal models neurologic, neurodegenerative, neuropsychiatric disorders. Clinical evidence included when available provide comprehensive perspective field acknowledge some limitations treatments. First, review describes how at drugs' primary targets—glycogen synthase kinase-3 for histone deacetylases VPA—induces transcription expression neurotrophic, angiogenic, neuroprotective proteins. Cell survival signaling cascades, oxidative stress pathways, protein quality control may further underlie VPA's beneficial actions. ability cotreatment augment neuroprotection enhance stem cell homing migration discussed, as microRNAs new targets. Finally, preclinical findings have shown benefits agents facilitate anti-inflammation, angiogenesis, neurogenesis, blood-brain barrier integrity, disease-specific neuroprotection. These can be compared with dysregulated disease suggest core molecular disturbances identifiable by specific risk biomarkers. Future clinical endeavors warranted determine across spectrum diseases, particular emphasis on personalized medicine approach toward treating

Language: Английский

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Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

Journal of Biological Chemistry, Journal Year: 2013, Volume and Issue: 288(37), P. 26926 - 26943

Published: July 30, 2013

Histone deacetylases (HDACs) are critical in the control of gene expression, and dysregulation their activity has been implicated a broad range diseases, including cancer, cardiovascular, neurological diseases. HDAC inhibitors (HDACi) employing different zinc chelating functionalities such as hydroxamic acids benzamides have shown promising results cancer therapy. Although it also suggested that HDACi with increased isozyme selectivity potency may broaden clinical utility minimize side effects, translation this idea to clinic remains be investigated. Moreover, detailed understanding how pharmacological properties affect biological functions vitro vivo is still missing. Here, we show panel benzamide-containing slow tight-binding long residence times unlike hydroxamate-containing vorinostat trichostatin-A. Characterization changes H2BK5 H4K14 acetylation following treatment neuroblastoma cell line SH-SY5Y revealed timing magnitude histone mirrored both association dissociation kinetic rates inhibitors. In contrast, viability microarray expression analysis indicated death induction transcriptional regulation do not correlate HDACi. Therefore, our study suggests determining selective inhibition function will help evaluate therapeutic utility.

Language: Английский

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Healthy Effects of Plant Polyphenols: Molecular Mechanisms

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(4), P. 1250 - 1250

Published: Feb. 13, 2020

The increasing extension in life expectancy of human beings developed countries is accompanied by a progressively greater rate degenerative diseases associated with lifestyle and aging, most which are still waiting for effective, not merely symptomatic, therapies. Accordingly, at present, the recommendations aimed reducing prevalence these conditions population limited to safer including physical/mental exercise, reduced caloric intake, proper diet convivial environment. claimed health benefits Mediterranean Asian diets have been confirmed many clinical trials epidemiological surveys. These characterized several features, low meat consumption, intake oils instead fats as lipid sources, moderate amounts red wine, significant fresh fruit vegetables. In particular, latter attracted popular scientific attention their content, though amounts, number molecules increasingly investigated healthy properties. Among latter, plant polyphenols raised remarkable interest community; fact, that Mediterranean/Asian can be traced back presence molecules, even though, some cases, contradictory results reported, highlights need further investigation. light trials, recent research has sought provide information on biochemical, molecular, epigenetic, cell biology modifications cell, organismal, animal, models cancer, metabolic, neurodegenerative pathologies, notably Alzheimer's Parkinson disease. findings reported last decade starting help decipher complex relations between homeostatic systems metabolic redox equilibrium, proteostasis, inflammatory response, establishing an solid molecular basis effects molecules. Taken together, data currently available, incomplete, providing rationale possible use natural polyphenols, or scaffolds, nutraceuticals contrast aging combat pathologies.

Language: Английский

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The epigenetics of aging and neurodegeneration

Progress in Neurobiology, Journal Year: 2015, Volume and Issue: 131, P. 21 - 64

Published: June 13, 2015

Language: Английский

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An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases

International Journal of Molecular Sciences, Journal Year: 2012, Volume and Issue: 14(1), P. 434 - 456

Published: Dec. 24, 2012

The endoplasmic reticulum (ER) is the major site of calcium storage and protein folding. It has a unique oxidizing-folding environment due to predominant disulfide bond formation during process Alterations in oxidative ER also intra-ER Ca2+ cause production stress-induced reactive oxygen species (ROS). Protein isomerases, oxidoreductin-1, reduced glutathione mitochondrial electron transport chain proteins play crucial roles ROS. In this article, we discuss stress-associated ROS related diseases, current understanding signaling transduction involved stress.

Language: Английский

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Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

Cell, Journal Year: 2014, Volume and Issue: 156(1-2), P. 261 - 276

Published: Jan. 1, 2014

Language: Английский

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