Science,
Journal Year:
2019,
Volume and Issue:
365(6454), P. 695 - 699
Published: Aug. 15, 2019
An
essential
prerequisite
for
the
survival
of
an
organism
is
ability
to
detect
and
respond
aversive
stimuli.
Current
belief
that
noxious
stimuli
directly
activate
nociceptive
sensory
nerve
endings
in
skin.
We
discovered
a
specialized
cutaneous
glial
cell
type
with
extensive
processes
forming
mesh-like
network
subepidermal
border
skin
conveys
thermal
mechanical
sensitivity.
demonstrate
direct
excitatory
functional
connection
neurons
provide
evidence
previously
unknown
organ
has
physiological
role
sensing
Thus,
these
cells,
which
are
intimately
associated
unmyelinated
nerves,
inherently
mechanosensitive
transmit
information
nerve.
Piezo
ion
channels
are
activated
by
various
types
of
mechanical
stimuli
and
function
as
biological
pressure
sensors
in
both
vertebrates
invertebrates.
To
date,
the
only
means
to
activate
whether
other
modes
activation
exist
is
not
known.
In
this
study,
we
screened
∼3.25
million
compounds
using
a
cell-based
fluorescence
assay
identified
synthetic
small
molecule
termed
Yoda1
that
acts
an
agonist
for
human
mouse
Piezo1.
Functional
studies
cells
revealed
affects
sensitivity
inactivation
kinetics
mechanically
induced
responses.
Characterization
artificial
droplet
lipid
bilayers
showed
activates
purified
Piezo1
absence
cellular
components.
Our
demonstrate
amenable
chemical
raise
possibility
endogenous
agonists
might
exist.
will
serve
key
tool
compound
study
regulation
function.
Advanced Science,
Journal Year:
2019,
Volume and Issue:
6(16)
Published: July 2, 2019
Abstract
Surface‐enhanced
Raman
scattering
(SERS)
spectroscopy
provides
a
noninvasive
and
highly
sensitive
route
for
fingerprint
label‐free
detection
of
wide
range
molecules.
Recently,
flexible
SERS
has
attracted
increasingly
tremendous
research
interest
due
to
its
unique
advantages
compared
rigid
substrate‐based
SERS.
Here,
the
latest
advances
in
diagnostic
devices
are
investigated
in‐depth.
First,
intriguing
prospect
point‐of‐care
diagnostics
is
briefly
described,
followed
by
an
introduction
cutting‐edge
technique.
Then,
focus
moved
from
conventional
emerging
The
main
part
this
report
highlights
recent
three
categories
substrates,
including
actively
tunable
SERS,
swab‐sampling
strategy,
situ
approach.
Furthermore,
other
promising
means
also
introduced.
substrates
with
low‐cost,
batch‐fabrication,
easy‐to‐operate
characteristics
can
be
integrated
into
portable
spectroscopes
diagnostics,
which
conceivable
penetrate
global
markets
households
as
next‐generation
wearable
sensors
near
future.
Trends in Neurosciences,
Journal Year:
2020,
Volume and Issue:
44(1), P. 3 - 16
Published: Dec. 29, 2020
Interoception
refers
to
the
representation
of
internal
states
an
organism,
and
includes
processes
by
which
it
senses,
interprets,
integrates,
regulates
signals
from
within
itself.
This
review
presents
a
unified
research
framework
attempts
offer
definitions
for
key
terms
describe
involved
in
interoception.
We
elaborate
on
these
through
illustrative
findings,
provide
brief
overviews
central
aspects
interoception,
including
anatomy
function
neural
non-neural
pathways,
diseases
disorders,
manipulations
interventions,
predictive
modeling.
conclude
with
discussions
about
major
gaps
challenges.
