A guiding map for inflammation

Nature Immunology, Journal Year: 2017, Volume and Issue: 18(8), P. 826 - 831

Published: July 19, 2017

Language: Английский

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Interleukin‐33 (IL‐33): A nuclear cytokine from the IL‐1 family

Immunological Reviews, Journal Year: 2017, Volume and Issue: 281(1), P. 154 - 168

Published: Dec. 16, 2017

Summary Interleukin‐33 ( IL ‐33) is a tissue‐derived nuclear cytokine from the ‐1 family abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like both during homeostasis inflammation. It functions as an alarm signal (alarmin) released upon cell injury or tissue damage to alert immune expressing ST 2 receptor RL 1). The major targets of ‐33 vivo are tissue‐resident such mast group innate lymphoid ILC 2s) regulatory T (Tregs). Other cellular include helper (Th2) eosinophils, basophils, dendritic Th1 CD 8 + NK iNKT B neutrophils macrophages. thus emerging crucial modulator with pleiotropic activities type‐2, type‐1 responses, important roles allergic, fibrotic, infectious, chronic inflammatory diseases. critical function ‐33/ signaling allergic inflammation illustrated by fact that 33 1 among most highly replicated susceptibility loci for asthma. In this review, we highlight 15 years discoveries on protein, including its molecular characteristics, localization, bioactive forms, sources, mechanisms release regulation proteases. Importantly, emphasize data have been validated using ‐deficient cells.

Language: Английский

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Mast cells as sources of cytokines, chemokines, and growth factors

Immunological Reviews, Journal Year: 2018, Volume and Issue: 282(1), P. 121 - 150

Published: Feb. 12, 2018

Mast cells are hematopoietic that reside in virtually all vascularized tissues and represent potential sources of a wide variety biologically active secreted products, including diverse cytokines growth factors. There is strong evidence for important non-redundant roles mast many types innate or adaptive immune responses, making contributions to immediate chronic IgE-associated allergic disorders enhancing host resistance certain venoms parasites. However, have been proposed influence other biological processes, responses bacteria virus, angiogenesis, wound healing, fibrosis, autoimmune metabolic disorders, cancer. The functions these settings thought reflect their ability secrete, upon appropriate activation by range non-immune stimuli, broad spectrum (including chemokines) factors, with autocrine, paracrine, local, systemic effects. In this review, we summarize the indicating which factors can be produced various populations rodent human response particular comment on proven such cell products health disease.

Language: Английский

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The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: May 15, 2020

The success of cancer immunotherapy relies on the knowledge tumor microenvironment and immune evasion mechanisms in which tumor, stroma infiltrating cells function a complex network. potential barriers that profoundly challenge overall clinical outcome promising therapies need to be fully identified counteracted. Although has increasingly been applied, we are far from understanding how utilize different strategies best way combine therapeutic options optimize benefit. This review intends give contemporary detailed overview roles cells, exosomes molecules acting they relate activation escape. Further, current novel immunotherapeutic will discussed.

Language: Английский

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The Broad Spectrum of Human Natural Killer Cell Diversity

Immunity, Journal Year: 2017, Volume and Issue: 47(5), P. 820 - 833

Published: Nov. 1, 2017

Language: Английский

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Interleukin-12 and -23 Control Plasticity of CD127+ Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria

Immunity, Journal Year: 2015, Volume and Issue: 43(1), P. 146 - 160

Published: July 1, 2015

Language: Английский

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Circulating and disseminated tumour cells — mechanisms of immune surveillance and escape

Nature Reviews Clinical Oncology, Journal Year: 2016, Volume and Issue: 14(3), P. 155 - 167

Published: Sept. 20, 2016

Language: Английский

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The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

Cell, Journal Year: 2016, Volume and Issue: 166(5), P. 1231 - 1246.e13

Published: Aug. 1, 2016

Language: Английский

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Single-cell transcriptomics to explore the immune system in health and disease

Science, Journal Year: 2017, Volume and Issue: 358(6359), P. 58 - 63

Published: Oct. 5, 2017

The immune system varies in cell types, states, and locations. complex networks, interactions, responses of cells produce diverse cellular ecosystems composed multiple accompanied by genetic diversity antigen receptors. Within this ecosystem, innate adaptive maintain protect tissue function, integrity, homeostasis upon changes functional demands insults. Characterizing inherent complexity requires studies at single-cell resolution. Recent advances such as massively parallel RNA sequencing sophisticated computational methods are catalyzing a revolution our understanding immunology. Here we provide an overview the state genomics outlook on use techniques to decipher components immunity.

Language: Английский

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Role of Vitamin A in the Immune System

Journal of Clinical Medicine, Journal Year: 2018, Volume and Issue: 7(9), P. 258 - 258

Published: Sept. 6, 2018

Vitamin A (VitA) is a micronutrient that crucial for maintaining vision, promoting growth and development, protecting epithelium mucus integrity in the body. VitA known as an anti-inflammation vitamin because of its critical role enhancing immune function. involved development system plays regulatory roles cellular responses humoral processes. has demonstrated therapeutic effect treatment various infectious diseases. To better understand relationship between nutrition system, authors review recent literature about immunity research briefly introduce clinical application several

Language: Английский

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