Understanding the tumor immune microenvironment (TIME) for effective therapy

Nature Medicine, Journal Year: 2018, Volume and Issue: 24(5), P. 541 - 550

Published: April 20, 2018

Language: Английский

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Inflammation and Cancer: Triggers, Mechanisms, and Consequences

Immunity, Journal Year: 2019, Volume and Issue: 51(1), P. 27 - 41

Published: July 1, 2019

Language: Английский

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Emerging Biological Principles of Metastasis

Cell, Journal Year: 2017, Volume and Issue: 168(4), P. 670 - 691

Published: Feb. 1, 2017

Language: Английский

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Neutrophil extracellular traps in immunity and disease

Nature reviews. Immunology, Journal Year: 2017, Volume and Issue: 18(2), P. 134 - 147

Published: Oct. 9, 2017

Language: Английский

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Macrophages as regulators of tumour immunity and immunotherapy

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 19(6), P. 369 - 382

Published: Feb. 4, 2019

Language: Английский

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Molecular principles of metastasis: a hallmark of cancer revisited

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: March 12, 2020

Abstract Metastasis is the hallmark of cancer that responsible for greatest number cancer-related deaths. Yet, it remains poorly understood. The continuous evolution biology research and emergence new paradigms in study metastasis have revealed some molecular underpinnings this dissemination process. invading tumor cell, on its way to target site, interacts with other proteins cells. Recognition these interactions improved understanding biological principles metastatic cell govern mobility plasticity. Communication microenvironment allows cells overcome stromal challenges, settle, colonize. These characteristics are driven by genetic epigenetic modifications within itself microenvironment. Establishing mechanisms process crucial finding open therapeutic windows successful interventions. In review, authors explore recent advancements field highlight latest insights contribute shaping cancer.

Language: Английский

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Roles of the immune system in cancer: from tumor initiation to metastatic progression

Genes & Development, Journal Year: 2018, Volume and Issue: 32(19-20), P. 1267 - 1284

Published: Oct. 1, 2018

The presence of inflammatory immune cells in human tumors raises a fundamental question oncology: How do cancer avoid the destruction by attack? In principle, tumor development can be controlled cytotoxic innate and adaptive cells; however, as develops from neoplastic tissue to clinically detectable tumors, evolve different mechanisms that mimic peripheral tolerance order tumoricidal attack. Here, we provide an update recent accomplishments, unifying concepts, future challenges study tumor-associated cells, with emphasis on metastatic carcinomas.

Language: Английский

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The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 374 - 403

Published: March 1, 2023

Language: Английский

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Neutrophils in cancer: neutral no more

Nature reviews. Cancer, Journal Year: 2016, Volume and Issue: 16(7), P. 431 - 446

Published: June 10, 2016

Language: Английский

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The Microenvironmental Landscape of Brain Tumors

Cancer Cell, Journal Year: 2017, Volume and Issue: 31(3), P. 326 - 341

Published: March 1, 2017

Language: Английский

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