The power of negative and positive episodic memories DOI Creative Commons
Samantha E. Williams, Jaclyn H. Ford, Elizabeth A. Kensinger

et al.

Cognitive Affective & Behavioral Neuroscience, Journal Year: 2022, Volume and Issue: 22(5), P. 869 - 903

Published: June 14, 2022

The power of episodic memories is that they bring a past moment into the present, providing opportunities for us to recall details experiences, reframe or update memory, and use retrieved information guide our decisions. In these regards, negative positive can be especially powerful: Life's highs lows are disproportionately represented in when retrieved, often impact current mood thoughts influence various forms behavior. Research rooted neuroscience cognitive psychology has historically focused on memory emotional content. Yet study autobiographical highlighted importance memories, more recently, methods have begun clarify why may show powerful relations mental wellbeing. Here, we review models been proposed explain long-lasting (durable) likely (accessible), describing how overlapping-but distinctly separable-ways, easier retrieve, We end by identifying potential implications this literature broader topics related wellbeing, education, workplace environments.

Language: Английский

Engrams and circuits crucial for systems consolidation of a memory DOI
Takashi Kitamura,

Sachie K. Ogawa,

Dheeraj S. Roy

et al.

Science, Journal Year: 2017, Volume and Issue: 356(6333), P. 73 - 78

Published: April 6, 2017

Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks permanent storage. However, engrams circuits that support memory consolidation have thus far been unknown. We found prefrontal engram cells, which critical remote contextual fear memory, were rapidly generated during initial learning through inputs from both hippocampal-entorhinal cortex network basolateral amygdala. After generation, with hippocampal became functionally mature time. Whereas cells silent time, amygdala, necessary maintained. Our data provide new insights into functional reorganization of underlying systems memory.

Language: Английский

Citations

1008
Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood DOI
Christoph Anacker, René Hen

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(6), P. 335 - 346

Published: May 4, 2017

Language: Английский

Citations

832
Light in diagnosis, therapy and surgery DOI
Seok Hyun Yun, Sheldon J. J. Kwok

Nature Biomedical Engineering, Journal Year: 2017, Volume and Issue: 1(1)

Published: Jan. 10, 2017

Language: Английский

Citations

676
Finding the engram DOI
Sheena A. Josselyn, Stefan Köhler, Paul W. Frankland

et al.

Nature reviews. Neuroscience, Journal Year: 2015, Volume and Issue: 16(9), P. 521 - 534

Published: Aug. 20, 2015

Language: Английский

Citations

587
Memory Engram Cells Have Come of Age DOI Creative Commons
Susumu Tonegawa, Xu Liu, Steve Ramirez

et al.

Neuron, Journal Year: 2015, Volume and Issue: 87(5), P. 918 - 931

Published: Sept. 1, 2015

Language: Английский

Citations

566
Memory engram storage and retrieval DOI Creative Commons
Susumu Tonegawa, Michele Pignatelli, Dheeraj S. Roy

et al.

Current Opinion in Neurobiology, Journal Year: 2015, Volume and Issue: 35, P. 101 - 109

Published: Aug. 14, 2015

A great deal of experimental investment is directed towards questions regarding the mechanisms memory storage. Such studies have traditionally been restricted to investigation anatomical structures, physiological processes, and molecular pathways necessary for capacity storage, avoided question how individual memories are stored in brain. Memory engram technology allows labeling subsequent manipulation components specific engrams particular brain regions, it has established that cell ensembles labeled by this method both sufficient recall. Recent research employed probe fundamental consolidation, differentiating between retrieval true neurobiology

Language: Английский

Citations

372
Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain DOI Creative Commons
Hiromu Monai, Masamichi Ohkura,

Mika Tanaka

et al.

Nature Communications, Journal Year: 2016, Volume and Issue: 7(1)

Published: March 22, 2016

Abstract Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various neurological conditions and enhance memory cognition in humans. tDCS has gained traction for its potential therapeutic value; however, little about mechanism of action. Using transgenic mouse expressing G-CaMP7 astrocytes subpopulation excitatory neurons, we find that induces large-amplitude astrocytic Ca 2+ surges across the entire cortex with no obvious changes local field potential. Moreover, sensory evoked cortical responses are enhanced after tDCS. These enhancements dependent on alpha-1 adrenergic receptor not observed IP 3 R2 (inositol trisphosphate type 2) knockout mice, which absent. Together, propose metaplasticity through /IP signalling.

Language: Английский

Citations

365
Animal models of major depression: drawbacks and challenges DOI Creative Commons

Barbara Planchez,

Alexandre Surget, Catherine Belzung

et al.

Journal of Neural Transmission, Journal Year: 2019, Volume and Issue: 126(11), P. 1383 - 1408

Published: Oct. 4, 2019

Major depression is a leading contributor to the global burden of disease. This situation mainly related chronicity and/or recurrence disorder, and poor response antidepressant therapy. Progress in this area requires valid animal models. Current models are based either on manipulating environment which rodents exposed (during developmental period or adulthood) biological underpinnings (i.e. gene deletion overexpression candidate genes, targeted lesions brain areas, optogenetic control specific neuronal populations, etc.). These manipulations can alter behavioural outcomes that be different symptomatic pathophysiological dimensions major depression. However, display substantial shortcomings contribute lack innovative pharmacological approaches recent decades hamper our capabilities investigate treatment-resistant Here, we discuss validity these models, review putative depression, subtypes recurrent Furthermore, identify future challenges regarding new paradigms such as those proposing dimensional rather than categorical

Language: Английский

Citations

365
The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric Disorders DOI Creative Commons
Florian Duclot, Mohamed Kabbaj

Frontiers in Behavioral Neuroscience, Journal Year: 2017, Volume and Issue: 11

Published: March 6, 2017

It is now clearly established that complex interactions between genes and environment are involved in multiple aspects of neuropsychiatric disorders, from determining an individual's vulnerability to onset, influencing its response therapeutic intervention. In this perspective, it appears crucial better understand how the organism reacts environmental stimuli provide a coordinated adapted response. central nervous system, neuronal plasticity neurotransmission among major processes integrating such stimuli. particular, immediate early (IEGs) critical components these as they molecular framework for rapid dynamic activity while opening possibility lasting sustained adaptation through regulation expression wide range genes. As result, IEGs have been tightly associated with well variety higher order within system learning, memory sensitivity reward. The gene transcription factor growth 1 (EGR1) has thus revealed mediator regulator synaptic both physiological pathological conditions. review article, we will focus on role EGR1 system. First, summarize different factors activity. Then, analyze amount data, including genome-wide, emerged recent years describing genes, pathways biological functions regulated directly or indirectly by EGR1. We be able gain insights into mechanisms underlying EGR1's Finally, discuss illustrate states particular interest cognitive disorders.

Language: Английский

Citations

303
Mental Imagery in Depression: Phenomenology, Potential Mechanisms, and Treatment Implications DOI
Emily A. Holmes, Simon E. Blackwell, Stephanie Burnett Heyes

et al.

Annual Review of Clinical Psychology, Journal Year: 2016, Volume and Issue: 12(1), P. 249 - 280

Published: Jan. 16, 2016

Mental imagery is an experience like perception in the absence of a percept. It ubiquitous feature human cognition, yet it has been relatively neglected etiology, maintenance, and treatment depression. Imagery abnormalities depression include excess intrusive negative mental imagery; impoverished positive bias for observer perspective overgeneral memory, which specific lacking. We consider contribution dysfunctions to depressive psychopathology implications cognitive behavioral interventions. Treatment advances capitalizing on representational format (as opposed its content) are reviewed, including rescripting, generation, memory specificity training. Consideration can contribute clinical assessment imagery-focused psychological therapeutic techniques promote investigation underlying mechanisms innovation. Research into at early stage. Work that bridges psychology neuroscience imagery-related recommended.

Language: Английский

Citations

291