The biology , function , and biomedical applications of exosomes

Science, Journal Year: 2020, Volume and Issue: 367(6478)

Published: Feb. 7, 2020

Clinical uses of cellular communication Exosomes are a type extracellular vesicle that contain constituents (protein, DNA, and RNA) the cells secrete them. They taken up by distant cells, where they can affect cell function behavior. Intercellular through exosomes seems to be involved in pathogenesis various disorders, including cancer, neurodegeneration, inflammatory diseases. In Review, Kalluri LeBleu discuss biogenesis disease, highlighting areas more research is needed. also potential clinical applications exosome profiling for diagnostics exosome-mediated delivery therapeutics target disease cells. Science , this issue p. eaau6977

Language: Английский

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Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

Cell, Journal Year: 2016, Volume and Issue: 164(6), P. 1226 - 1232

Published: March 1, 2016

Language: Английский

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Regulation of microRNA function in animals

Nature Reviews Molecular Cell Biology, Journal Year: 2018, Volume and Issue: 20(1), P. 21 - 37

Published: Aug. 14, 2018

Language: Английский

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Molecular principles of metastasis: a hallmark of cancer revisited

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: March 12, 2020

Abstract Metastasis is the hallmark of cancer that responsible for greatest number cancer-related deaths. Yet, it remains poorly understood. The continuous evolution biology research and emergence new paradigms in study metastasis have revealed some molecular underpinnings this dissemination process. invading tumor cell, on its way to target site, interacts with other proteins cells. Recognition these interactions improved understanding biological principles metastatic cell govern mobility plasticity. Communication microenvironment allows cells overcome stromal challenges, settle, colonize. These characteristics are driven by genetic epigenetic modifications within itself microenvironment. Establishing mechanisms process crucial finding open therapeutic windows successful interventions. In review, authors explore recent advancements field highlight latest insights contribute shaping cancer.

Language: Английский

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Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

Cancer Cell, Journal Year: 2016, Volume and Issue: 30(6), P. 836 - 848

Published: Dec. 1, 2016

Language: Английский

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The Microenvironmental Landscape of Brain Tumors

Cancer Cell, Journal Year: 2017, Volume and Issue: 31(3), P. 326 - 341

Published: March 1, 2017

Language: Английский

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RNA delivery by extracellular vesicles in mammalian cells and its applications

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 21(10), P. 585 - 606

Published: May 26, 2020

Language: Английский

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Tumor microenvironment as a therapeutic target in cancer

Pharmacology & Therapeutics, Journal Year: 2020, Volume and Issue: 221, P. 107753 - 107753

Published: Nov. 28, 2020

Language: Английский

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Extracellular Vesicles: Unique Intercellular Delivery Vehicles

Trends in Cell Biology, Journal Year: 2016, Volume and Issue: 27(3), P. 172 - 188

Published: Dec. 13, 2016

Language: Английский

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Extracellular vesicles in cancer — implications for future improvements in cancer care

Nature Reviews Clinical Oncology, Journal Year: 2018, Volume and Issue: 15(10), P. 617 - 638

Published: May 23, 2018

Language: Английский

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