Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics

Science, Journal Year: 2018, Volume and Issue: 359(6376), P. 679 - 684

Published: Feb. 9, 2018

Stimulating deep inside the brain Noninvasive stimulation is an important goal in neuroscience and neuroengineering. Optogenetics normally requires use of a blue laser inserted into brain. Chen et al. used specialized nanoparticles that can upconvert near-infrared light from outside local emission (see Perspective by Feliu ). They injected these ventral tegmental area mouse activated channelrhodopsin expressed dopaminergic neurons with generated skull at distance several millimeters. This technique allowed distant to evoke fast increases dopamine release. The method was also successfully fear memories dentate gyrus during conditioning. Science , this issue p. 679 ; see 633

Language: Английский

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Prefrontal–hippocampal interactions in episodic memory

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(9), P. 547 - 558

Published: June 28, 2017

Language: Английский

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Integration of optogenetics with complementary methodologies in systems neuroscience

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(4), P. 222 - 235

Published: March 17, 2017

Language: Английский

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Simultaneous fast measurement of circuit dynamics at multiple sites across the mammalian brain

Nature Methods, Journal Year: 2016, Volume and Issue: 13(4), P. 325 - 328

Published: Feb. 15, 2016

Language: Английский

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Next-generation probes, particles, and proteins for neural interfacing

Science Advances, Journal Year: 2017, Volume and Issue: 3(6)

Published: June 2, 2017

Multimodal and multidisciplinary approaches lead to next-generation technologies for reading modulating neural function.

Language: Английский

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Global Representations of Goal-Directed Behavior in Distinct Cell Types of Mouse Neocortex

Neuron, Journal Year: 2017, Volume and Issue: 94(4), P. 891 - 907.e6

Published: May 1, 2017

The successful planning and execution of adaptive behaviors in mammals may require long-range coordination neural networks throughout cerebral cortex. neuronal implementation signals that could orchestrate cortex-wide activity remains unclear. Here, we develop apply methods for Ca2+ imaging mice performing decision-making behavior identify a global cortical representation task engagement encoded the dynamics both single cells superficial neuropil distributed across majority dorsal multiple molecularly defined cell types was found to reflect this with type-specific dynamics. Focal optogenetic inhibition tiled cortex revealed crucial role frontal triggering phenomenon; local region blocked response task-initiating cues voluntary behavior. These findings reveal cell-type-specific processes globally representing goal-directed major node gates broadcast task-related information.

Language: Английский

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The hippocampal sharp wave–ripple in memory retrieval for immediate use and consolidation

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(12), P. 744 - 757

Published: Oct. 24, 2018

Language: Английский

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Parallel emergence of stable and dynamic memory engrams in the hippocampus

Nature, Journal Year: 2018, Volume and Issue: 558(7709), P. 292 - 296

Published: June 1, 2018

Language: Английский

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The microbiota regulate neuronal function and fear extinction learning

Nature, Journal Year: 2019, Volume and Issue: 574(7779), P. 543 - 548

Published: Oct. 23, 2019

Language: Английский

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All-Optical Interrogation of Neural Circuits

Journal of Neuroscience, Journal Year: 2015, Volume and Issue: 35(41), P. 13917 - 13926

Published: Oct. 14, 2015

There have been two recent revolutionary advances in neuroscience: First, genetically encoded activity sensors brought the goal of optical detection single action potentials vivo within reach. Second, optogenetic actuators now allow neurons to be controlled with millisecond precision. These revolutions combined, together advanced microscopies, “all-optical” readout and manipulation neural circuits single-spike single-neuron This is a transformational advance that will open new frontiers neuroscience research. Harnessing power light all-optical approach requires coexpression probes same neurons, as well ability simultaneously target record from selected neurons. It has recently become possible combine strategies are sufficiently sensitive cross talk free enable single-action-potential sensitivity precision for both intact brain. The combination simultaneous defined cells wide range experiments inspire technologies interacting described this review herald future where traditional tools used generations by physiologists study interact brain—stimulation recording electrodes—can largely replaced light. We outline potential developments field discuss how strategy can applied solve fundamental problems neuroscience. SIGNIFICANCE STATEMENT describes nexus dramatic probes, sensors, novel which recorded manipulated entirely using protein engineering form basis single-action functionally promise illuminate many challenges neuroscience, including transforming our search code links between circuit behavior.

Language: Английский

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