Nature,
Journal Year:
2018,
Volume and Issue:
565(7739), P. 361 - 365
Published: Dec. 21, 2018
The
fast-growing
field
of
bioelectronic
medicine
aims
to
develop
engineered
systems
that
can
relieve
clinical
conditions
by
stimulating
the
peripheral
nervous
system1-5.
This
type
technology
relies
largely
on
electrical
stimulation
provide
neuromodulation
organ
function
or
pain.
One
example
is
sacral
nerve
treat
overactive
bladder,
urinary
incontinence
and
interstitial
cystitis
(also
known
as
bladder
pain
syndrome)4,6,7.
Conventional,
continuous
protocols,
however,
cause
discomfort
pain,
particularly
when
treating
symptoms
be
intermittent
(for
example,
sudden
urgency)8.
Direct
physical
coupling
electrodes
lead
injury
inflammation9-11.
Furthermore,
typical
therapeutic
stimulators
target
large
bundles
innervate
multiple
structures,
resulting
in
a
lack
specificity.
Here
we
introduce
miniaturized
bio-optoelectronic
implant
avoids
these
limitations
using
(1)
an
optical
interface
exploits
microscale
inorganic
light-emitting
diodes
activate
opsins;
(2)
soft,
high-precision
biophysical
sensor
system
allows
measurements
function;
(3)
control
module
data
analytics
approach
enables
coordinated,
closed-loop
operation
eliminate
pathological
behaviours
they
occur
real-time.
In
reported
here,
soft
strain
gauge
yields
real-time
information
rat
model.
Data
algorithms
identify
behaviour,
automated,
optogenetic
sensory
afferents
normalizes
function.
all-optical
scheme
for
offers
chronic
stability
potential
stimulate
specific
cell
types.
Advanced Functional Materials,
Journal Year:
2018,
Volume and Issue:
29(6)
Published: Nov. 28, 2018
Abstract
Flexible
electronics,
as
an
emerging
and
exciting
research
field,
have
brought
great
interest
to
the
issue
of
how
make
flexible
electronic
materials
that
offer
both
durability
high
performance
at
strained
states.
With
advent
on‐body
wearable
implantable
well
increasing
demands
for
human‐friendly
intelligent
soft
robots,
enormous
effort
is
being
expended
on
highly
functional
materials,
especially
stretchable
electrodes,
by
academic
industrial
communities.
Among
different
deformation
modes,
stretchability
most
demanding
challenging.
This
review
focuses
latest
advances
in
transparent
electrodes
based
a
new
design
strategy
known
kirigami
(the
art
paper
cutting)
investigates
recent
progress
novel
applications,
including
skin‐like
biodegradable
devices,
bioinspired
robotics.
By
comparing
optoelectrical
mechanical
properties
electrode
some
important
outcomes
with
comments
their
merits
demerits
are
raised.
Key
considerations
terms
geometries,
substrates,
adhesion
also
discussed,
offering
insights
into
universal
strategies
engineering
regardless
material.
It
suggested
biocompatible
will
greatly
boost
development
next‐generation
life‐like
electronics.
Advanced Materials,
Journal Year:
2018,
Volume and Issue:
30(50)
Published: Aug. 2, 2018
Soft
electronics
are
intensively
studied
as
the
integration
of
with
dynamic
nonplanar
surfaces
has
become
necessary.
Here,
a
discussion
strategies
in
materials
innovation
and
structural
design
to
build
soft
electronic
devices
systems
is
provided.
For
each
strategy,
presentation
focuses
on
fundamental
science
mechanics,
example
device
applications
highlighted
where
possible.
Finally,
perspectives
key
challenges
future
directions
this
field
presented.
Advanced Functional Materials,
Journal Year:
2020,
Volume and Issue:
31(11)
Published: Dec. 29, 2020
Abstract
In
comparison
to
traditional
bulky
and
rigid
electronic
devices,
the
human–machine
interaction
(HMI)
system
with
flexible
wearable
components
is
an
inevitable
future
trend.
To
achieve
effective,
intuitive,
seamless
manipulation
of
high‐performance
HMI
systems,
it
important
develop
effective
strategies
for
designing
material
microstructures
on
sensors
electric
devices
excellent
mechanical
flexibility
stretchability.
The
real‐time
acquisition
human
physiology
surrounding
signals
through
accurate
basis
HMIs.
Herein,
construction
a
that
utilizes
sensors,
communication
modes,
actuators
reviewed.
mechanisms
various
based
different
are
analyzed
discussed.
functional
mechanism,
selection,
novel
design
each
part
summarized
in
detail.
modes
interactive
systems
manufacturing
technology
soft
machines
also
introduced.
Additionally,
most
advanced
applications
intelligent
identification
security,
controls
robots,
augmented
reality,
virtual
reality
have
been
highlighted.
review
concludes
overview
remaining
key
challenges
several
ideas
regarding
further
improvement
systems.
