Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(6), P. 4185 - 4219

Published: Jan. 1, 2021

Molecular design directions for overcoming the photodynamic therapy challenges.

Language: Английский

---

The light of carbon dots: From mechanism to applications

Matter, Journal Year: 2022, Volume and Issue: 5(1), P. 110 - 149

Published: Jan. 1, 2022

Language: Английский

---

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 4996 - 5041

Published: Jan. 1, 2022

This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.

Language: Английский

---

Organic photosensitizers for antimicrobial phototherapy

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(9), P. 3324 - 3340

Published: Jan. 1, 2022

This tutorial review highlights the concept and significance of antibacterial phototherapy. Recent developments, advantages, challenges organic photosensitizers in this area are also discussed.

Language: Английский

---

Metalated covalent organic frameworks: from synthetic strategies to diverse applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(15), P. 6307 - 6416

Published: Jan. 1, 2022

This review highlights the recent advances of metalated covalent organic frameworks, including synthetic strategies and applications, discusses current challenges future directions.

Language: Английский

---

Low-Temperature Photothermal Therapy: Strategies and Applications

Research, Journal Year: 2021, Volume and Issue: 2021

Published: Jan. 1, 2021

Although photothermal therapy (PTT) with the assistance of nanotechnology has been considered as an indispensable strategy in biomedical field, it still encounters some severe problems that need to be solved. Excessive heat can induce treated cells develop thermal resistance, and thus, efficacy PTT may dramatically decreased. In meantime, uncontrollable diffusion pose a threat surrounding healthy tissues. Recently, low-temperature (also known mild or mild-temperature PTT) demonstrated its remarkable capacity conquering these obstacles shown excellent performance bacterial elimination, wound healing, cancer treatments. Herein, we summarize recently proposed strategies for achieving based on nanomaterials introduce synthesis, characteristics, applications nanoplatforms. Additionally, combination other therapeutic modalities defeating cancers synergistic effect combined treatments are discussed. Finally, current limitations future directions inspiring more researchers make contributions promoting toward successful preclinical clinical disease

Language: Английский

---

Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT

ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 4162 - 4174

Published: March 1, 2022

Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy (PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy acceptor planarization and donor rotation proposed to design I photosensitizers (PSs) photothermal reagents. Acceptor can not only enforce intramolecular charge transfer redshift NIR absorption but also PSs from photochemical pathways. Donor optimizes conversion efficiency (PCE). Accordingly, three 3,6-divinyl-substituted diketopyrrolopyrrole (DPP) derivatives, 2TPAVDPP, TPATPEVDPP, 2TPEVDPP, with different number rotors were prepared. Experimental results showed that compounds excellent PSs, corresponding 2TPEVDPP nanoparticles (NPs) most possessed highest PCE. The photophysical properties NPs are particularly suitable for in vivo fluorescence imaging-guided synergistic PDT/PTT therapy. helpful exploiting phototherapeutic reagents high efficacy PDT PTT.

Language: Английский

---

Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy

Light Science & Applications, Journal Year: 2020, Volume and Issue: 9(1)

Published: Sept. 15, 2020

Abstract Here, we describe a combination strategy of black phosphorus (BP)-based photothermal therapy together with anti-CD47 antibody (aCD47)-based immunotherapy to synergistically enhance cancer treatment. Tumour resistance immune checkpoint blockades in most cancers due escape from host surveillance, along the initiation metastasis through immunosuppressive cells tumour microenvironment, remains significant challenge for immunotherapy. aCD47, an agent CD47/SIRPα axis blockade, induces modest phagocytic activity and low response rate monotherapy, resulting failures clinical trials. We showed that BP-mediated ablation tumours effects could serve as effective specific immunological stimulation, improving inherently poor immunogenicity tumours, which is particularly useful enhancing BP aCD47 blockade activates both innate adaptive immunities promotes local systemic anticancer responses, thus offering enhanced effect suppression progression inducing abscopal inhibition metastatic cancers. Our provides promising platform agents help therapeutic efficacy

Language: Английский

---

Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment

ACS Nano, Journal Year: 2021, Volume and Issue: 15(8), P. 12567 - 12603

Published: Aug. 2, 2021

Immunotherapy that harnesses the human immune system to fight cancer has received widespread attention and become a mainstream strategy for treatment. Cancer immunotherapy not only eliminates primary tumors but also treats metastasis recurrence, representing major advantage over traditional treatments. Recently with development of nanotechnology, there exists much work applying nanomaterials on basis their excellent physiochemical properties, such as efficient tissue-specific delivery function, huge specific surface area, controllable chemistry. Consequently, nanotechnology holds significant potential in improving efficacy immunotherapy. Nanotechnology-based mainly manifests its inhibitory effect via two different approaches: one is produce an effective anti-tumor response during tumorigenesis, other enhance tumor defense ability by modulating suppression mechanism microenvironment. With success immunotherapy, understanding interaction between smart nanomedicine provided vigorous vitality This review highlights application, progress, prospect process immunoediting discusses several engineering methods improve efficiency

Language: Английский

---

Chemistry, Functionalization, and Applications of Recent Monoelemental Two-Dimensional Materials and Their Heterostructures

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(1), P. 1127 - 1207

Published: Nov. 15, 2021

The past decades have witnessed a rapid expansion in investigations of two-dimensional (2D) monoelemental materials (Xenes), which are promising various fields, including applications optoelectronic devices, biomedicine, catalysis, and energy storage. Apart from graphene phosphorene, recently emerging 2D Xenes, specifically graphdiyne, borophene, arsenene, antimonene, bismuthene, tellurene, attracted considerable interest due to their unique optical, electrical, catalytic properties, endowing them broader range intriguing applications. In this review, the structures properties these Xenes summarized based on theoretical experimental results. synthetic approaches for fabrication, mainly bottom-up top-down, presented. Surface modification strategies also shown. wide nonlinear optical optoelectronics, application further discussed. Finally, review concludes with an assessment current status, description existing scientific challenges, discussion possible directions advance fertile field.

Language: Английский

---