Journal of Hematology & Oncology,
Journal Year:
2019,
Volume and Issue:
12(1)
Published: Aug. 28, 2019
Among
all
the
stromal
cells
that
present
in
tumor
microenvironment,
cancer-associated
fibroblasts
(CAFs)
are
one
of
most
abundant
and
critical
components
mesenchyme,
which
not
only
provide
physical
support
for
but
also
play
a
key
role
promoting
retarding
tumorigenesis
context-dependent
manner.
CAFs
have
been
involved
modulation
many
immune
system,
recent
studies
revealed
their
roles
evasion
poor
responses
to
cancer
immunotherapy.
In
this
review,
we
describe
our
current
understanding
tumorigenic
significance,
origin,
heterogeneity
CAFs,
as
well
different
subtypes
distinct
cell
types.
More
importantly,
highlight
potential
therapeutic
strategies
target
unleash
system
against
tumor.
Nature reviews. Cancer,
Journal Year:
2020,
Volume and Issue:
20(3), P. 174 - 186
Published: Jan. 24, 2020
Abstract
Cancer-associated
fibroblasts
(CAFs)
are
a
key
component
of
the
tumour
microenvironment
with
diverse
functions,
including
matrix
deposition
and
remodelling,
extensive
reciprocal
signalling
interactions
cancer
cells
crosstalk
infiltrating
leukocytes.
As
such,
they
potential
target
for
optimizing
therapeutic
strategies
against
cancer.
However,
many
challenges
present
in
ongoing
attempts
to
modulate
CAFs
benefit.
These
include
limitations
our
understanding
origin
heterogeneity
CAF
function,
it
being
desirable
retain
some
antitumorigenic
functions.
On
basis
meeting
experts
field
biology,
we
summarize
this
Consensus
Statement
current
knowledge
framework
advancing
critical
cell
type
within
microenvironment.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Oct. 9, 2020
Abstract
Tissues
are
dynamically
shaped
by
bidirectional
communication
between
resident
cells
and
the
extracellular
matrix
(ECM)
through
cell-matrix
interactions
ECM
remodelling.
Tumours
leverage
remodelling
to
create
a
microenvironment
that
promotes
tumourigenesis
metastasis.
In
this
review,
we
focus
on
how
tumour
tumour-associated
stromal
deposit,
biochemically
biophysically
modify,
degrade
ECM.
These
tumour-driven
changes
support
growth,
increase
migration
of
cells,
remodel
in
distant
organs
allow
for
metastatic
progression.
A
better
understanding
underlying
mechanisms
tumourigenic
is
crucial
developing
therapeutic
treatments
patients.
Physiological Reviews,
Journal Year:
2014,
Volume and Issue:
94(4), P. 1287 - 1312
Published: Oct. 1, 2014
The
transcriptional
regulators
YAP
and
TAZ
are
the
focus
of
intense
interest
given
their
remarkable
biological
properties
in
development,
tissue
homeostasis
cancer.
activity
is
key
for
growth
whole
organs,
amplification
tissue-specific
progenitor
cells
during
renewal
regeneration,
cell
proliferation.
In
tumors,
YAP/TAZ
can
reprogram
cancer
into
stem
incite
tumor
initiation,
progression
metastasis.
As
such,
appealing
therapeutic
targets
regenerative
medicine.
Just
like
function
offers
a
molecular
entry
point
mysteries
biology,
regulation
by
upstream
cues
equally
captivating.
well
known
being
effectors
Hippo
signaling
cascade,
mouse
mutants
pathway
components
display
phenotypes
organ
overgrowth,
enhanced
content
reduced
cellular
differentiation.
primary
sensors
cell's
physical
nature,
as
defined
structure,
shape
polarity.
activation
also
reflects
“social”
behavior,
including
adhesion
mechanical
signals
that
receives
from
architecture
surrounding
extracellular
matrix
(ECM).
At
same
time,
entertain
relationships
with
morphogenetic
signals,
such
Wnt
factors,
regulated
Rho,
GPCRs
mevalonate
metabolism.
thus
appear
at
centerpiece
nexus
which
take
control
behavior
according
to
own
shape,
spatial
location
factor
context.
Molecular Cancer,
Journal Year:
2021,
Volume and Issue:
20(1)
Published: Oct. 11, 2021
Abstract
Cancer-associated
fibroblasts
(CAFs),
a
stromal
cell
population
with
cell-of-origin,
phenotypic
and
functional
heterogeneity,
are
the
most
essential
components
of
tumor
microenvironment
(TME).
Through
multiple
pathways,
activated
CAFs
can
promote
growth,
angiogenesis,
invasion
metastasis,
along
extracellular
matrix
(ECM)
remodeling
even
chemoresistance.
Numerous
previous
studies
have
confirmed
critical
role
interaction
between
cells
in
tumorigenesis
development.
However,
recently,
mutual
effects
immune
(TIME)
been
identified
as
another
key
factor
promoting
progression.
The
TIME
mainly
consists
distinct
populations
islets
is
highly
associated
antitumor
immunological
state
TME.
interact
tumor-infiltrating
well
other
within
via
secretion
various
cytokines,
growth
factors,
chemokines,
exosomes
effector
molecules,
consequently
shaping
an
immunosuppressive
TME
that
enables
cancer
to
evade
surveillance
system.
In-depth
interactions,
particularly
complicated
mechanisms
connecting
cells,
might
provide
novel
strategies
for
subsequent
targeted
immunotherapies.
Herein,
we
shed
light
on
recent
advances
regarding
direct
indirect
crosstalk
infiltrating
further
summarize
possible
immunoinhibitory
induced
by
In
addition,
present
current
related
CAF-targeting
immunotherapies
briefly
describe
some
future
perspectives
CAF
research
end.
