Journal of Hematology & Oncology,
Journal Year:
2019,
Volume and Issue:
12(1)
Published: Aug. 28, 2019
Among
all
the
stromal
cells
that
present
in
tumor
microenvironment,
cancer-associated
fibroblasts
(CAFs)
are
one
of
most
abundant
and
critical
components
mesenchyme,
which
not
only
provide
physical
support
for
but
also
play
a
key
role
promoting
retarding
tumorigenesis
context-dependent
manner.
CAFs
have
been
involved
modulation
many
immune
system,
recent
studies
revealed
their
roles
evasion
poor
responses
to
cancer
immunotherapy.
In
this
review,
we
describe
our
current
understanding
tumorigenic
significance,
origin,
heterogeneity
CAFs,
as
well
different
subtypes
distinct
cell
types.
More
importantly,
highlight
potential
therapeutic
strategies
target
unleash
system
against
tumor.
Science,
Journal Year:
2018,
Volume and Issue:
361(6409)
Published: Sept. 28, 2018
Waking
up
in
a
trap
Cancer
patients
who
have
undergone
successful
treatment
can
experience
relapse
of
their
disease
years
or
even
decades
later.
This
is
because
cancer
cells
that
disseminated
beyond
the
primary
tumor
site
enter
state
dormancy,
where
they
remain
viable
but
not
proliferating.
Eventually,
by
mechanisms
are
poorly
understood,
these
clinically
undetectable
“wake
up”
and
form
actively
growing
metastases.
Studying
mouse
models,
Albrengues
et
al.
found
sustained
lung
inflammation
accompanying
formation
neutrophil
extracellular
traps
(NETs)
could
convert
dormant
to
aggressive
metastases
(see
Perspective
Aguirre-Ghiso).
Awakening
was
associated
with
NET-mediated
remodeling
matrix
be
prevented
an
antibody
against
remodeled
version
protein
called
laminin-111.
Science
,
this
issue
p.
eaao4227
;
see
also
1314
Annual Review of Biochemistry,
Journal Year:
2018,
Volume and Issue:
88(1), P. 577 - 604
Published: Dec. 19, 2018
The
Hippo
pathway
was
initially
discovered
in
Drosophila
melanogaster
as
a
key
regulator
of
tissue
growth.
It
is
an
evolutionarily
conserved
signaling
cascade
regulating
numerous
biological
processes,
including
cell
growth
and
fate
decision,
organ
size
control,
regeneration.
core
the
mammals
consists
kinase
cascade,
MST1/2
LATS1/2,
well
downstream
effectors,
transcriptional
coactivators
YAP
TAZ.
These
components
control
programs
involved
proliferation,
survival,
mobility,
stemness,
differentiation.
tightly
regulated
by
both
intrinsic
extrinsic
signals,
such
mechanical
force,
cell-cell
contact,
polarity,
energy
status,
stress,
many
diffusible
hormonal
factors,
majority
which
act
through
G
protein-coupled
receptors.
Here,
we
review
current
understanding
molecular
mechanisms
signals
regulate
with
emphasis
on
mechanotransduction
effects
this
basic
biology
human
diseases.
International Journal of Molecular Sciences,
Journal Year:
2018,
Volume and Issue:
19(10), P. 3028 - 3028
Published: Oct. 4, 2018
The
immense
diversity
of
extracellular
matrix
(ECM)
proteins
confers
distinct
biochemical
and
biophysical
properties
that
influence
cell
phenotype.
ECM
is
highly
dynamic
as
it
constantly
deposited,
remodelled,
degraded
during
development
until
maturity
to
maintain
tissue
homeostasis.
ECM’s
composition
organization
are
spatiotemporally
regulated
control
behaviour
differentiation,
but
dysregulation
dynamics
leads
the
diseases
such
cancer.
chemical
cues
presented
by
have
been
appreciated
key
drivers
for
both
cancer
progression.
However,
mechanical
forces
present
due
largely
ignored
recently
recognized
play
critical
roles
in
disease
progression
malignant
behaviour.
Here,
we
review
ways
which
microenvironment
regulation
phenotype
stages
human
Signal Transduction and Targeted Therapy,
Journal Year:
2020,
Volume and Issue:
5(1)
Published: Aug. 25, 2020
Abstract
Accumulating
evidence
shows
that
cellular
and
acellular
components
in
tumor
microenvironment
(TME)
can
reprogram
initiation,
growth,
invasion,
metastasis,
response
to
therapies.
Cancer
research
treatment
have
switched
from
a
cancer-centric
model
TME-centric
one,
considering
the
increasing
significance
of
TME
cancer
biology.
Nonetheless,
clinical
efficacy
therapeutic
strategies
targeting
TME,
especially
specific
cells
or
pathways
remains
unsatisfactory.
Classifying
chemopathological
characteristics
crosstalk
among
one
another
greatly
benefit
further
studies
exploring
effective
treating
methods.
Herein,
we
present
an
updated
image
with
emphasis
on
hypoxic
niche,
immune
microenvironment,
metabolism
acidic
innervated
mechanical
microenvironment.
We
then
summarize
conventional
drugs
including
aspirin,
celecoxib,
β-adrenergic
antagonist,
metformin,
statin
new
antitumor
application.
These
are
considered
as
viable
candidates
for
combination
therapy
due
their
activity
extensive
use
practice.
also
provide
our
outlook
directions
potential
applications
theory.
This
review
depicts
comprehensive
vivid
landscape
biology
treatment.
The Journal of Cell Biology,
Journal Year:
2016,
Volume and Issue:
215(4), P. 445 - 456
Published: Nov. 8, 2016
Cells
can
detect
and
react
to
the
biophysical
properties
of
extracellular
environment
through
integrin-based
adhesion
sites
adapt
milieu
in
a
process
called
mechanotransduction.
At
these
sites,
integrins
connect
matrix
(ECM)
with
F-actin
cytoskeleton
transduce
mechanical
forces
generated
by
actin
retrograde
flow
myosin
II
ECM
mechanosensitive
focal
proteins
that
are
collectively
termed
“molecular
clutch.”
The
transmission
across
adhesions
establishes
reciprocity
between
viscoelasticity
cellular
tension.
During
mechanotransduction,
force
allosterically
alters
functions
within
elicit
biochemical
signals
regulate
both
rapid
responses
mechanics
long-term
changes
gene
expression.
Integrin-mediated
mechanotransduction
plays
important
roles
development
tissue
homeostasis,
its
dysregulation
is
often
associated
diseases.
Physiological Reviews,
Journal Year:
2020,
Volume and Issue:
101(1), P. 147 - 176
Published: May 29, 2020
Efforts
to
develop
anti-cancer
therapies
have
largely
focused
on
targeting
the
epithelial
compartment,
despite
presence
of
non-neoplastic
stromal
components
that
substantially
contribute
progression
tumor.
Indeed,
cancer
cell
survival,
growth,
migration,
and
even
dormancy
are
influenced
by
surrounding
tumor
microenvironment
(TME).
Within
TME,
cancer-associated
fibroblasts
(CAFs)
been
shown
play
several
roles
in
development
a
They
secrete
growth
factors,
inflammatory
ligands,
extracellular
matrix
proteins
promote
proliferation,
therapy
resistance,
immune
exclusion.
However,
recent
work
indicates
CAFs
may
also
restrain
some
circumstances.
In
this
review,
we
summarize
body
CAFs,
with
particular
focus
most
discoveries
about
fibroblast
heterogeneity,
plasticity,
functions.
We
highlight
commonalities
present
across
different
types,
normal
states.
Finally,
latest
advances
regarding
therapeutic
strategies
undergoing
preclinical
clinical
evaluation.
