Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(7), P. 398 - 411
Published: June 2, 2020
Language: Английский
Immunity, Journal Year: 2019, Volume and Issue: 51(1), P. 27 - 41
Published: July 1, 2019
Language: Английский
Citations
2801
Cell Research, Journal Year: 2019, Volume and Issue: 29(5), P. 347 - 364
Published: April 4, 2019
Cells may die from accidental cell death (ACD) or regulated (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms have been identified are increasingly being implicated in various human pathologies. Here, we critically review the current state art regarding types RCD, including necroptosis, pyroptosis, ferroptosis, entotic death, netotic parthanatos, lysosome-dependent autophagy-dependent alkaliptosis oxeiptosis. The in-depth comprehension each these lethal subroutines their intercellular consequences uncover therapeutic targets for avoidance pathogenic loss.
Language: Английский
Citations
2000
Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)
Published: March 12, 2020
Abstract Metastasis is the hallmark of cancer that responsible for greatest number cancer-related deaths. Yet, it remains poorly understood. The continuous evolution biology research and emergence new paradigms in study metastasis have revealed some molecular underpinnings this dissemination process. invading tumor cell, on its way to target site, interacts with other proteins cells. Recognition these interactions improved understanding biological principles metastatic cell govern mobility plasticity. Communication microenvironment allows cells overcome stromal challenges, settle, colonize. These characteristics are driven by genetic epigenetic modifications within itself microenvironment. Establishing mechanisms process crucial finding open therapeutic windows successful interventions. In review, authors explore recent advancements field highlight latest insights contribute shaping cancer.
Language: Английский
Citations
1803
Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 374 - 403
Published: March 1, 2023
Language: Английский
Citations
1595
Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)
Published: Oct. 9, 2020
Abstract Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions ECM remodelling. Tumours leverage remodelling to create a microenvironment that promotes tumourigenesis metastasis. In this review, we focus on how tumour tumour-associated stromal deposit, biochemically biophysically modify, degrade ECM. These tumour-driven changes support growth, increase migration of cells, remodel in distant organs allow for metastatic progression. A better understanding underlying mechanisms tumourigenic is crucial developing therapeutic treatments patients.
Language: Английский
Citations
1594
Nature Reviews Molecular Cell Biology, Journal Year: 2019, Volume and Issue: 20(8), P. 457 - 473
Published: June 10, 2019
Language: Английский
Citations
1030
Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(5), P. 280 - 297
Published: Jan. 31, 2022
Language: Английский
Citations
987
Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(9), P. 485 - 503
Published: July 21, 2020
Language: Английский
Citations
882
Nature Medicine, Journal Year: 2021, Volume and Issue: 27(1), P. 34 - 44
Published: Jan. 1, 2021
Language: Английский
Citations
748
Cancer Cell, Journal Year: 2019, Volume and Issue: 35(3), P. 347 - 367
Published: March 1, 2019
Language: Английский
Citations
731