Reprogramming of fatty acid metabolism in cancer

British Journal of Cancer, Journal Year: 2019, Volume and Issue: 122(1), P. 4 - 22

Published: Dec. 10, 2019

Abstract A common feature of cancer cells is their ability to rewire metabolism sustain the production ATP and macromolecules needed for cell growth, division survival. In particular, importance altered fatty acid in has received renewed interest as, aside principal role as structural components membrane matrix, they are important secondary messengers, can also serve fuel sources energy production. this review, we will examine mechanisms through which with a focus on four main areas research. (1) The de novo synthesis exogenous uptake cellular pool acids. (2) molecular heterogeneity oncogenic signal transduction pathways, such PI3K–AKT–mTOR signalling, regulate metabolism. (3) acids essential mediators progression metastasis, remodelling tumour microenvironment. (4) Therapeutic strategies considerations successfully targeting cancer. Further research focusing complex interplay between signalling dysregulated holds great promise uncover novel metabolic vulnerabilities improve efficacy targeted therapies.

Language: Английский

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SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

Nature Reviews Endocrinology, Journal Year: 2017, Volume and Issue: 13(12), P. 710 - 730

Published: Aug. 29, 2017

Language: Английский

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Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

Molecular Cell, Journal Year: 2020, Volume and Issue: 78(6), P. 1019 - 1033

Published: June 1, 2020

Language: Английский

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Progress in tumor-associated macrophage (TAM)-targeted therapeutics

Advanced Drug Delivery Reviews, Journal Year: 2017, Volume and Issue: 114, P. 206 - 221

Published: April 25, 2017

Language: Английский

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Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(9), P. 2167 - 2167

Published: May 1, 2019

Biological membranes are key elements for the maintenance of cell architecture and physiology. Beyond a pure barrier separating inner space from outer, plasma membrane is scaffold player in cell-to-cell communication initiation intracellular signals among other functions. Critical to this function compartmentalization lipid microdomains that control localization productive interactions proteins involved signal propagation. In addition, cells divided into compartments limited by whose integrity homeostasis finely controlled, which determine identity different organelles. Here, we review current knowledge on composition endomembrane compartments, emphasizing its role sustaining organelle structure function. The correct define pathophysiological aspects cells. Therefore, explore therapeutic potential manipulating with approaches like therapy, aiming normalize functions through modification bilayers.

Language: Английский

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Extracellular ATP and P2 purinergic signalling in the tumour microenvironment

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 18(10), P. 601 - 618

Published: July 13, 2018

Language: Английский

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Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy

Cell Metabolism, Journal Year: 2017, Volume and Issue: 26(1), P. 94 - 109

Published: July 1, 2017

Language: Английский

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Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 159, P. 245 - 293

Published: Jan. 1, 2020

With the advent of effective tools to study lipids, including mass spectrometry-based lipidomics, lipids are emerging as central players in cancer biology. Lipids function essential building blocks for membranes, serve fuel drive energy-demanding processes and play a key role signaling molecules regulators numerous cellular functions. Not unexpectedly, cells, well other cell types tumor microenvironment, exploit various ways acquire extensively rewire their metabolism part plastic context-dependent metabolic reprogramming that is driven by both oncogenic environmental cues. The resulting changes fate composition help cells thrive changing microenvironment supporting functions hallmarks, energetics, promoting feedforward signaling, resisting oxidative stresses, regulating intercellular communication immune responses. Supported close connection between altered lipid pathogenic process, specific profiles unique disease biomarkers, with diagnostic, prognostic predictive potential. Multiple preclinical studies illustrate translational promise exploiting cancer, critically, have shown context dependent actionable vulnerabilities can be rationally targeted, particularly combinatorial approaches. Moreover, themselves used membrane disrupting agents or components nanocarriers therapeutics. number compounds strategies approaching clinical trials, we at doorstep hitherto underappreciated hallmark promising target oncologist's strategy combat cancer.

Language: Английский

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Significance of long chain polyunsaturated fatty acids in human health

Clinical and Translational Medicine, Journal Year: 2017, Volume and Issue: 6(1)

Published: July 27, 2017

Abstract In the last decades, development of new technologies applied to lipidomics has revitalized analysis lipid profile alterations and understanding underlying molecular mechanisms metabolism, together with their involvement in occurrence human disease. Of particular interest is study omega‐3 omega‐6 long chain polyunsaturated fatty acids (LC‐PUFAs), notably EPA (eicosapentaenoic acid, 20:5n‐3), DHA (docosahexaenoic 22:6n‐3), ARA (arachidonic 20:4n‐6), transformation into bioactive mediators. this sense, families PUFA‐derived mediators, including resolvins derived from DHA, protectins maresins are being increasingly investigated because active role “return homeostasis” process resolution inflammation. Recent findings reviewed present highlight that acid appears increased, decreased most cancer tissues compared normal ones, increments LC‐PUFAs consumption an omega‐6/omega‐3 ratio 2–4:1, associated a reduced risk breast, prostate, colon renal cancers. Along lipid‐lowering properties, also exert cardioprotective functions, such as reducing platelet aggregation inflammation, controlling presence our body, especially liver brain, which crucial for optimal brain functionality. Considering principal FA cortical gray matter, importance intake its mediators have been recently reported patients major depressive bipolar disorders, Alzheimer disease, Parkinson's amyotrophic lateral sclerosis. The reviews relationships between diseases occurring today Western world LC‐PUFAs. More specifically review focuses on dietary balance, wide range inflammation autoimmune diseases. This suggests current recommendations and/or supplementation FAs specific groups age physiological status, still need more fine tuning overall health well being.

Language: Английский

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Lipid metabolism in cancer: New perspectives and emerging mechanisms

Developmental Cell, Journal Year: 2021, Volume and Issue: 56(10), P. 1363 - 1393

Published: May 1, 2021

Language: Английский

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