Science Advances,
Journal Year:
2019,
Volume and Issue:
5(5)
Published: May 3, 2019
Resistance
to
platinum-based
chemotherapy
is
a
common
event
in
patients
with
cancer,
generally
associated
tumor
dissemination
and
metastasis.
Whether
platinum
treatment
per
se
activates
molecular
pathways
linked
spreading
not
known.
Here,
we
report
that
the
ubiquitin-specific
protease
1
(USP1)
mediates
ovarian
cancer
cell
resistance
platinum,
by
regulating
stability
of
Snail,
which,
turn,
promotes
dissemination.
At
level,
observed
upon
treatment,
USP1
phosphorylated
ATM
ATR
binds
Snail.
Then,
de-ubiquitinates
stabilizes
Snail
expression,
conferring
increased
stem
cell-like
features,
metastatic
ability.
Consistently,
knockout
or
pharmacological
inhibition
sensitivity
decreased
Snail-dependent
manner.
Our
findings
identify
as
target
open
way
novel
strategy
overcome
more
successfully
treat
cancer.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Jan. 10, 2022
Abstract
Prostate
cancer
is
the
second
most
common
malignancy
in
men
worldwide
and
consists
of
a
mixture
tumor
non-tumor
cell
types.
To
characterize
prostate
microenvironment,
we
perform
single-cell
RNA-sequencing
on
biopsies,
prostatectomy
specimens,
patient-derived
organoids
from
localized
patients.
We
uncover
heterogeneous
cellular
states
epithelial
cells
marked
by
high
androgen
signaling
that
are
enriched
identify
population
tumor-associated
club
may
be
associated
with
carcinogenesis.
ERG
-negative
cells,
compared
to
-positive
demonstrate
shared
heterogeneity
surrounding
luminal
appear
give
rise
microenvironment
responses.
Finally,
show
harbor
distinct
types
their
parent
tissues.
Our
results
provide
diagnostically
relevant
insights
advance
our
understanding
Molecular Metabolism,
Journal Year:
2020,
Volume and Issue:
35, P. 100962 - 100962
Published: Feb. 13, 2020
Nucleotide
metabolism
is
a
critical
pathway
that
generates
purine
and
pyrimidine
molecules
for
DNA
replication,
RNA
synthesis,
cellular
bioenergetics.
Increased
nucleotide
supports
uncontrolled
growth
of
tumors
hallmark
cancer.
Agents
inhibiting
synthesis
incorporation
nucleotides
in
are
widely
used
as
chemotherapeutics
to
reduce
tumor
growth,
cause
damage,
induce
cell
death.
Thus,
the
research
on
cancer
primarily
focused
its
role
proliferation.
However,
addition
proliferation,
established
ligands
purinergic
signals.
so
far,
pyrimidines
has
not
been
discussed
beyond
growth.
In
this
review
we
present
key
evidence
from
recent
pivotal
studies
supporting
notion
non-proliferative
(PyM)
cancer,
with
special
focus
effect
differentiation
cancers
different
origins.
leukemic
cells,
catabolism
induces
terminal
toward
monocytic
lineage
check
aberrant
whereas
some
solid
(e.g.,
triple
negative
breast
hepatocellular
carcinoma),
catalytic
degradation
maintains
mesenchymal-like
state
driven
by
epithelial-to-mesenchymal
transition
(EMT).
This
further
broadens
concept
understand
PyM
metastasis
and,
ultimately,
delivers
rationale
investigate
involvement
oncometabolites.
Overall,
understanding
will
lead
improvement
existing
antimetabolites
development
new
therapeutic
options.
Frontiers in Pharmacology,
Journal Year:
2021,
Volume and Issue:
12
Published: May 17, 2021
Lung
cancer
is
the
most
common
and
fatal
malignant
tumor
in
world.
The
microenvironment
(TME)
closely
related
to
occurrence
development
of
lung
cancer,
which
inflammatory
plays
an
important
role.
Inflammatory
cells
factors
promote
activation
NF-κB
STAT3
pathways
occurrence,
development,
metastasis
by
promoting
immune
escape,
angiogenesis,
epithelial–mesenchymal
transition,
apoptosis,
other
mechanisms.
Clinical
epidemiological
studies
have
also
shown
a
strong
relationship
among
chronic
infection,
inflammation,
microenvironment,
cancer.
between
inflammation
can
be
better
understood
through
gradual
understanding
advantageous
find
more
therapeutic
targets
for
Metabolism Open,
Journal Year:
2025,
Volume and Issue:
25, P. 100347 - 100347
Published: Jan. 9, 2025
The
highly
nuanced
transition
from
an
inflammatory
process
to
tumorigenesis
is
of
great
scientific
interest.
While
it
well
known
that
environmental
stimuli
can
cause
inflammation,
less
about
the
oncogenic
modifications
chronic
inflammation
in
tissue
microenvironment
bring
about,
as
how
these
set
off
pro-tumorigenic
processes.
It
clear
no
matter
where
factors
come
from,
maintaining
encourages
carcinogenesis.
In
addition
encouraging
angiogenesis
and
metastatic
processes,
sustaining
survival
proliferation
malignant
transformed
cells,
possibly
altering
efficacy
therapeutic
agents,
negatively
regulate
antitumoral
adaptive
innate
immune
responses.
Because
has
multiple
pathways
involved
metastasis,
gained
recognition
a
marker
cancer
desirable
target
for
therapy.
Recent
advances
our
knowledge
molecular
mechanisms
drive
cancer's
progression
demonstrate
promotes
metastasis
while
suppressing
anti-tumor
immunity.
many
solid
tumor
types,
including
breast,
lung,
liver
cancer,
stimulates
activation
oncogenes
impairs
body's
defenses
against
tumor.
Additionally,
alters
As
tactical
approach
treatment,
findings
have
underscored
importance
targeting
pathways.
This
review
highlights
role
development
focusing
on
its
impact
progression,
suppression,
therapy
resistance.
examines
current
anti-inflammatory
strategies,
NSAIDs,
cytokine
modulators,
STAT3
inhibitors,
addressing
their
potential
limitations.
emphasizes
need
further
research
unravel
complex
linking
identify
targets
specific
subtypes.
The Journal of Experimental Medicine,
Journal Year:
2019,
Volume and Issue:
216(6), P. 1234 - 1243
Published: April 25, 2019
A
link
between
chronic
inflammation
and
development
of
tumors
is
well
established.
Moreover,
it
has
become
evident
that
tumorigenesis
not
a
cell
autonomous
disease,
an
inflammatory
microenvironment
prerequisite
basically
all
tumors,
including
those
emerge
in
the
absence
overt
inflammation.
This
knowledge
led
to
anti-inflammatory
concepts
treat
prevent
cancer.
In
contrast,
immunotherapies,
particular
checkpoint
inhibitors,
representing
most
significant
progress
therapy
several
malignancies
depend
on
presence
pro-inflammatory
“hot”
environment.
Here,
we
discuss
pro-
for
treatment
Cold Spring Harbor Perspectives in Medicine,
Journal Year:
2019,
Volume and Issue:
10(7), P. a036905 - a036905
Published: Sept. 30, 2019
Toni
Celià-Terrassa1
and
Mohit
Kumar
Jolly2
1Cancer
Research
Program,
IMIM
(Hospital
del
Mar
Medical
Institute),
08003
Barcelona,
Spain
2Centre
for
BioSystems
Science
Engineering,
Indian
Institute
of
Science,
Bangalore
560012,
India
Correspondence:
acelia{at}imim.es;
mkjolly{at}iisc.ac.in
