Implant infections: adhesion, biofilm formation and immune evasion

Nature Reviews Microbiology, Journal Year: 2018, Volume and Issue: 16(7), P. 397 - 409

Published: May 2, 2018

Language: Английский

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Biofilm Matrixome: Extracellular Components in Structured Microbial Communities

Trends in Microbiology, Journal Year: 2020, Volume and Issue: 28(8), P. 668 - 681

Published: April 21, 2020

The 'matrixome' is the inventory of currently known biomolecules (polysaccharides, nucleic acids, proteins, lipids, and lipoproteins) their molecular, structural, functional diversity associated with biofilm assembly, its physicochemical virulence attributes.The structural biochemical properties matrixome provide emergent biofilms, including surface adhesion, spatial chemical heterogeneities, synergistic/competitive polymicrobial interactions, antimicrobial recalcitrance, virulence.Combinatorial treatment strategies are crucial to eradicate biofilms by targeting functionally structurally complex extracellular polymeric matrix embedded microbial cells.Due limited knowledge EPS there an urgent need for more experimental in vivo mechanistic studies. Biofilms consist communities a 3D matrix. composed array substances (EPS) that contribute unique attributes lifestyle virulence. This ensemble chemically diverse termed 'matrixome'. composition mechanisms formation, role biology, function, microenvironment being revealed. perspective article highlights recent advances about multifaceted development, physical–chemical properties, biofilms. We emphasize biofilm-specific conditions such as could lead precise effective antibiofilm approaches. also discuss context in-depth analyses mixed many human infectious diseases.

Language: Английский

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Types and origins of bacterial membrane vesicles

Nature Reviews Microbiology, Journal Year: 2018, Volume and Issue: 17(1), P. 13 - 24

Published: Nov. 5, 2018

Language: Английский

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Oral Biofilms: Pathogens, Matrix, and Polymicrobial Interactions in Microenvironments

Trends in Microbiology, Journal Year: 2017, Volume and Issue: 26(3), P. 229 - 242

Published: Oct. 30, 2017

Language: Английский

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Pseudomonas aeruginosa Biofilms

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(22), P. 8671 - 8671

Published: Nov. 17, 2020

Pseudomonas aeruginosa is an opportunistic human pathogen causing devastating acute and chronic infections in individuals with compromised immune systems. Its highly notorious persistence clinical settings attributed to its ability form antibiotic-resistant biofilms. Biofilm architecture built mostly by autogenic extracellular polymeric substances which function as a scaffold encase the bacteria together on surfaces, protect them from environmental stresses, impedes phagocytosis thereby conferring capacity for colonization long-term persistence. Here we review current knowledge P. biofilms, development stages, molecular mechanisms of invasion conferred Explosive cell lysis within bacterial biofilm produce essential communal materials, interspecies biofilms commensal Streptococcus virulence possibly improves disease conditions will also be discussed. Recent research diagnostics investigated. Finally, therapeutic strategies treatment along their advantages limitations compiled.

Language: Английский

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Extracellular membrane vesicles in the three domains of life and beyond

FEMS Microbiology Reviews, Journal Year: 2018, Volume and Issue: 43(3), P. 273 - 303

Published: Nov. 20, 2018

Cells from all three domains of life, Archaea, Bacteria and Eukarya, produce extracellular vesicles (EVs) which are sometimes associated with filamentous structures known as nanopods or nanotubes. The mechanisms EV biogenesis in the remain poorly understood, although studies Eukarya indicate that regulation lipid composition plays a major role initiating membrane curvature. EVs increasingly recognized important mediators intercellular communication via transfer wide variety molecular cargoes. They have been implicated many aspects cell physiology such stress response, competition, lateral gene (via RNA DNA), pathogenicity detoxification. Their various human pathologies aging has aroused much interest recent years. can be used decoys against viral attack but virus-infected cells also boost infection. Here, we review current knowledge on life their interactions world.

Language: Английский

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Cystic Fibrosis and Pseudomonas aeruginosa: the Host-Microbe Interface

Clinical Microbiology Reviews, Journal Year: 2019, Volume and Issue: 32(3)

Published: May 28, 2019

In human pathophysiology, the clash between microbial infection and host immunity contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this phenomenon, wherein dysfunctional, hyperinflammatory immune response combined with chronic pulmonary infections wreak havoc upon airway, leading disease course substantial morbidity shortened life span.

Language: Английский

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Molecular and Evolutionary Determinants of Bacteriophage Host Range

Trends in Microbiology, Journal Year: 2018, Volume and Issue: 27(1), P. 51 - 63

Published: Sept. 1, 2018

Language: Английский

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Biofilms: hot spots of horizontal gene transfer (HGT) in aquatic environments, with a focus on a new HGT mechanism

FEMS Microbiology Ecology, Journal Year: 2020, Volume and Issue: 96(5)

Published: Feb. 27, 2020

Biofilms in water environments are thought to be hot spots for horizontal gene transfer (HGT) of antibiotic resistance genes (ARGs). ARGs can spread via HGT, though mechanisms known and have been shown depend on the environment, bacterial communities mobile genetic elements. Classically, HGT include conjugation, transformation transduction; more recently, membrane vesicles (MVs) reported as DNA reservoirs implicated interspecies HGT. Here, we review current knowledge with a focus role MVs methodological innovations research.

Language: Английский

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The dental plaque biofilm matrix

Periodontology 2000, Journal Year: 2021, Volume and Issue: 86(1), P. 32 - 56

Published: March 10, 2021

Abstract The extracellular matrix is a critical component of microbial biofilms, such as dental plaque, maintaining the spatial arrangement cells and coordinating cellular functions throughout structure. polymeric substances that comprise include carbohydrates, nucleic acids, proteins, lipids, which are frequently organized into macromolecular complexes and/or associated with surfaces within biofilm. Cariogenic plaque rich in glucan fructan polysaccharides derived from metabolism dietary sucrose. By contrast, subgingival complex mixture macromolecules still not well understood. Components escape during lysis by active secretion or through shedding vesicles serve to anchor tooth surface. biofilm close association host tissues, facilitates interactions between microorganisms host. outcome these may be maintenance health development disease, caries periodontitis. affords protection against chemical physical insults hinders eradication pathogenic plaque. Therefore, strategies control maintain oral health. This review discusses recent advances our understanding composition, origins, function matrix, focus on New based targeting also considered.

Language: Английский

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