Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse DOI Creative Commons
Joachim Ahlbeck, Lingzhen Song, Mattia Chini

et al.

eLife, Journal Year: 2018, Volume and Issue: 7

Published: April 10, 2018

The long-range coupling within prefrontal-hippocampal networks that account for cognitive performance emerges early in life. discontinuous hippocampal theta bursts have been proposed to drive the generation of neonatal prefrontal oscillations, yet cellular substrate these interactions is still unresolved. Here, we selectively target optogenetic manipulation glutamatergic projection neurons CA1 area either dorsal or intermediate/ventral hippocampus at age elucidate their contribution emergence oscillatory entrainment. We show despite stronger and ripples power hippocampus, cortex mainly coupled with by phase-locking neuronal firing via dense direct axonal projections. Theta band-confined activation light pyramidal but not were transfected utero electroporation high-efficiency channelrhodopsin boosts oscillations. Our data causally origin developing brain.

Language: Английский

Resolving and Rescuing Developmental Miswiring in a Mouse Model of Cognitive Impairment DOI Creative Commons
Mattia Chini, Jastyn A. Pöpplau, Christoph Lindemann

et al.

Neuron, Journal Year: 2019, Volume and Issue: 105(1), P. 60 - 74.e7

Published: Nov. 13, 2019

Cognitive deficits, core features of mental illness, largely result from dysfunction prefrontal networks. This emerges during early development, before a detectable behavioral readout, yet the cellular elements controlling abnormal maturation are still unknown. Here, we address this open question by combining in vivo electrophysiology, optogenetics, neuroanatomy, and assays development mice mimicking dual genetic-environmental etiology psychiatric disorders. We report that pyramidal neurons superficial layers cortex key causing disorganized oscillatory entrainment local circuits beta-gamma frequencies. Their firing rate timing relate to sparser dendritic arborization lower spine density. Administration minocycline first postnatal week, potentially acting via microglial cells, rescues neuronal deficits restores pre-juvenile cognitive abilities. Elucidation substrate developmental miswiring later opens new perspectives for identification neurobiological targets amenable therapies.

Language: Английский

Citations

62
Morphological and functional evidence of increased excitatory signaling in the prelimbic cortex during ethanol withdrawal DOI Creative Commons
Florence P. Varodayan, Harpreet Sidhu, Max Kreifeldt

et al.

Neuropharmacology, Journal Year: 2018, Volume and Issue: 133, P. 470 - 480

Published: Feb. 19, 2018

Language: Английский

Citations

61
Gamma activity accelerates during prefrontal development DOI Creative Commons
Sebastian H. Bitzenhofer, Jastyn A. Pöpplau, Ileana L. Hanganu‐Opatz

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Nov. 18, 2020

Gamma oscillations are a prominent activity pattern in the cerebral cortex. While gamma rhythms have been extensively studied adult prefrontal cortex context of cognitive (dys)functions, little is known about their development. We addressed this issue by using extracellular recordings and optogenetic stimulations mice across postnatal show that fast rhythmic becomes during second week. initially at 15 Hz, oscillatory progressively accelerates with age stabilizes within frequency range (30-80 Hz) fourth Activation layer 2/3 pyramidal neurons drives throughout development, yet acceleration follows similar temporal dynamics as maturation fast-spiking interneurons. These findings uncover development provide framework to examine origin abnormal neurodevelopmental disorders.

Language: Английский

Citations

52
Post-error recruitment of frontal sensory cortical projections promotes attention in mice DOI Creative Commons

Kevin J. Norman,

Justin S. Riceberg,

Hiroyuki Koike

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(7), P. 1202 - 1213.e5

Published: Feb. 21, 2021

Language: Английский

Citations

52
Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation DOI Creative Commons
Jastyn A. Pöpplau,

Timo Schwarze,

Мария Дорофейкова

et al.

Neuron, Journal Year: 2023, Volume and Issue: 112(3), P. 421 - 440.e7

Published: Nov. 17, 2023

Most cognitive functions involving the prefrontal cortex emerge during late development. Increasing evidence links this delayed maturation to protracted timeline of development, which likely does not reach full maturity before end adolescence. However, underlying mechanisms that drive emergence and fine-tuning abilities adolescence, caused by circuit wiring, are still unknown. Here, we continuously monitored activity throughout postnatal development mice showed an initial increase was interrupted extensive microglia-mediated breakdown activity, followed rewiring elements achieve adult-like patterns synchrony. Interfering with these processes but adulthood, led a long-lasting microglia-induced disruption neuronal morphology decreased abilities. These results identified nonlinear reorganization circuits adolescence revealed its importance for adult network function processing.

Language: Английский

Citations

19
Dynamic amplitude modulation of microstimulation evokes biomimetic onset and offset transients and reduces depression of evoked calcium responses in sensory cortices DOI Creative Commons
Christopher Hughes, Takashi D.Y. Kozai

Brain stimulation, Journal Year: 2023, Volume and Issue: 16(3), P. 939 - 965

Published: May 1, 2023

Intracortical microstimulation (ICMS) is an emerging approach to restore sensation people with neurological injury or disease. Biomimetic microstimulation, stimulus trains that mimic neural activity in the brain through encoding of onset and offset transients, could improve utility ICMS for brain-computer interface (BCI) applications, but how biomimetic affects activation not understood. Current "biomimetic" aim reproduce strong transients evoked by sensory input dynamic modulation parameters. Stimulus induced depression (decreases intensity over time) also a potential barrier clinical implementation feedback, may reduce this effect.

Language: Английский

Citations

18
Active Sleep Promotes Functional Connectivity in Developing Sensorimotor Networks DOI
Carlos Del Rio‐Bermudez, Mark S. Blumberg

BioEssays, Journal Year: 2018, Volume and Issue: 40(4)

Published: March 6, 2018

A ubiquitous feature of active (REM) sleep in mammals and birds is its relative abundance early development. In rat pups across the first two postnatal weeks, promotes expression synchronized oscillatory activity within between cortical subcortical sensorimotor structures. Sensory feedback from self‐generated myoclonic twitches – which are produced exclusively during also triggers neural oscillations those We have proposed that one functions infancy to provide a context for synchronizing developing Specifically, contribute variety neurodevelopmental processes, including synapse formation, neuronal differentiation migration, apoptosis, refinement topographic maps. addition, promote functional connectivity distant brain areas. Consequently, any condition or manipulation restricts can, turn, deprive infant animal substantial sensory experience, resulting atypical developmental trajectories.

Language: Английский

Citations

57
Optogenetic approaches to study the mammalian brain DOI Creative Commons

Jan Deubner,

Philippe Coulon, Ilka Diester

et al.

Current Opinion in Structural Biology, Journal Year: 2019, Volume and Issue: 57, P. 157 - 163

Published: May 10, 2019

Optogenetics has revolutionized neurobiological research by allowing to disentangle intricate neuronal circuits at a spatio-temporal precision unmatched other techniques. Here, we review current advances of optogenetic applications in mammals, especially focusing on freely moving animals. State-of-the-art strategies allow the targeted expression opsins subpopulations, defined either genetic cell type or projection pattern. Optogenetic manipulations these subpopulations become particularly powerful when combined with behavioral paradigms and neurophysiological readout Thereby, specific roles can be assigned identified cells. All-optical approaches opportunity write complex three dimensional patterns into networks have recently emerged. While clinical implications new tool set seem tempting, emphasize here role optogenetics for basic research.

Language: Английский

Citations

49
A 0.13-<inline-formula> <tex-math notation="LaTeX">$\mu\text{m}$ </tex-math> </inline-formula> CMOS SoC for Simultaneous Multichannel Optogenetics and Neural Recording DOI
Gabriel Gagnon-Turcotte, Mehdi Noormohammadi Khiarak, Christian Éthier

et al.

IEEE Journal of Solid-State Circuits, Journal Year: 2018, Volume and Issue: 53(11), P. 3087 - 3100

Published: Sept. 3, 2018

This paper presents a 0.13-μm CMOS system-onchip (SoC) for simultaneous multichannel optogenetics and neural recording in freely moving laboratory animals. fully integrated system provides 10 multimodal channels with analog-to-digital conversion fourchannel LED driver circuit optogenetic stimulation. The bio-amplifier design includes programmable bandwidth (BW) (0.5 Hz-7 kHz) to collect either the action potentials (APs) and/or local field (LFPs) has noise efficiency factor (NEF) of 2.30 an input-referred 3.2 μVrms within BW 10-7 kHz. low-power delta-sigma (ΔΣ) MASH 1-1-1 converter (ADC) is designed work at low oversampling ratios (OSRs) (≤50) effective number bits (ENOB) 9.75 OSR 25 (BW kHz). utilization ΔΣ ADC key address flexibility needed different versus power consumption tradeoff various experimental settings. It leverages new technique that reduces its size by subtracting output each branch digital domain, instead analog domain as done conventionally. followed on-chip fourthorder cascaded integrator-comb (CIC4) decimation filter (DF). A whole channel, including bio-amplifier, 1-1-1, DF consumes 11.2 μW. Optical stimulation performed using regulated cascode current source feedback can accommodate wide range parameters battery voltages. SoC validated vivo wireless platform both ventral posteromedial nucleus (VPM) cerebral motor cortex brain regions virally mediated Channelrhodopsin-2 (ChR2) rat.

Language: Английский

Citations

47
Genetically encoded fluorescent sensors for imaging neuronal dynamics in vivo DOI Open Access
Julian Day‐Cooney, Rochelin Dalangin, Haining Zhong

et al.

Journal of Neurochemistry, Journal Year: 2022, Volume and Issue: 164(3), P. 284 - 308

Published: March 14, 2022

The brain relies on many forms of dynamic activities in individual neurons, from synaptic transmission to electrical activity and intracellular signaling events. Monitoring these neuronal with high spatiotemporal resolution the context animal behavior is a necessary step achieve mechanistic understanding function. With rapid development dissemination highly optimized genetically encoded fluorescent sensors, growing number can now be visualized vivo. To date, cellular calcium imaging, which has been largely used as proxy for activity, become mainstay systems neuroscience. While challenges remain, voltage imaging neural populations possible. In addition, it becoming increasingly practical image over half dozen neurotransmitters, well certain metabolic activities. These new capabilities enable neuroscientists test previously unattainable hypotheses questions. This review summarizes recent progress delivery highlights example applications vivo imaging.

Language: Английский

Citations

27