Elements of cancer immunity and the cancer–immune set point

Nature, Journal Year: 2017, Volume and Issue: 541(7637), P. 321 - 330

Published: Jan. 1, 2017

Language: Английский

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Pathways to zoonotic spillover

Nature Reviews Microbiology, Journal Year: 2017, Volume and Issue: 15(8), P. 502 - 510

Published: May 30, 2017

Language: Английский

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The evolution of seasonal influenza viruses

Nature Reviews Microbiology, Journal Year: 2017, Volume and Issue: 16(1), P. 47 - 60

Published: Oct. 30, 2017

Language: Английский

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Photo-Inspired Antibacterial Activity and Wound Healing Acceleration by Hydrogel Embedded with Ag/Ag@AgCl/ZnO Nanostructures

ACS Nano, Journal Year: 2017, Volume and Issue: 11(9), P. 9010 - 9021

Published: Aug. 21, 2017

Ag/Ag@AgCl/ZnO hybrid nanostructures are embedded in a hydrogel by simple two-step technique. The Ag/Ag@AgCl assembled the via ultraviolet light chemical reduction followed incorporation of ZnO NaOH precipitation. accelerates wound healing and exhibits high antibacterial efficiency against both Escherichia coli Staphylococcus aureus under visible irradiation. enhance photocatalytic activity due to enhancement reactive oxygen species light. This system kills 95.95% E. 98.49% S. within 20 min upon exposure simulated light, rapid sterilization plays crucial role healing. In addition, this provides controllable, sustained release silver zinc ions over period 21 days arising from reversible swelling-shrinking transition triggered changing pH value biological environment. About 90% Zn2+ is observed acidic environment after 3 days, whereas only 10% occurs neutral days. vivo results show that Ag+ stimulates immune function produce large number white blood cells neutrophils (2-4 times more than control), thereby producing synergistic effects accelerated

Language: Английский

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Human immune system variation

Nature reviews. Immunology, Journal Year: 2016, Volume and Issue: 17(1), P. 21 - 29

Published: Dec. 5, 2016

Language: Английский

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Debunking the Myth of Exercise-Induced Immune Suppression: Redefining the Impact of Exercise on Immunological Health Across the Lifespan

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 9

Published: April 16, 2018

Epidemiological evidence indicates that regular physical activity and/or frequent structured exercise reduces the incidence of many chronic diseases in older age, including communicable such as viral and bacterial infections, well non-communicable cancer inflammatory disorders. Despite apparent health benefits achieved by leading an active lifestyle, which imply enhance immune competency regulation, effect a single bout on function remains controversial topic. Indeed, to this day, it is perceived vigorous can temporarily suppress function. In first part review, we deconstruct key pillars lay foundation theory-referred "open window" hypothesis-and highlight that: (i) limited reliable exists support claim heightens risk opportunistic infections; (ii) purported changes mucosal immunity, namely salivary IgA levels, after do not signpost period suppression; (iii) dramatic reductions lymphocyte numbers 1-2 h reflects transient time-dependent redistribution cells peripheral tissues, resulting heightened state surveillance opposed suppression. second provide enhances-rather than suppresses-immune competency, findings from human vaccination studies show responses antigens following bouts exercise. Finally, third might limit or delay aging system, providing further beneficial for immunological health. summary, over-arching aim review rebalance opinion over relationships between We emphasize misconception label any form acute immunosuppressive, and, instead, most likely improves across lifespan.

Language: Английский

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Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures

Endocrine Reviews, Journal Year: 2016, Volume and Issue: 37(6), P. 584 - 608

Published: Oct. 20, 2016

Abstract Circadian (∼24-hour) timing systems pervade all kingdoms of life and temporally optimize behavior physiology in humans. Relatively recent changes to our environments, such as the introduction artificial lighting, can disorganize circadian system, from level molecular clocks that regulate cellular activities synchronization between daily cycles solar day. Sleep/wake are intertwined with global trends indicate these, too, increasingly subject disruption. A large proportion world's population is at increased risk environmentally driven rhythm sleep disruption, a minority individuals also genetically predisposed misalignment disorders. The consequences disruption system profound include myriad metabolic ramifications, some which may be compounded by adverse effects on dietary choices. If not addressed, deleterious will continue cause widespread health problems; therefore, implementation numerous behavioral pharmaceutical interventions help restore alignment enhance important.

Language: Английский

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Melatonin as a Hormone: New Physiological and Clinical Insights

Endocrine Reviews, Journal Year: 2018, Volume and Issue: 39(6), P. 990 - 1028

Published: Sept. 12, 2018

Melatonin is a ubiquitous molecule present in almost every live being from bacteria to humans. In vertebrates, besides produced peripheral tissues and acting as an autocrine paracrine signal, melatonin centrally synthetized by neuroendocrine organ, the pineal gland. Independently of considered species, hormone always during night its production secretory episode duration are directly dependent on length night. As tightly linked light/dark cycle, main hormonal systemic integrative action coordinate behavioral physiological adaptations environmental geophysical day season. The circadian signal daily regularity, contrast between concentrations, specially developed ways action. During episode, coordinates adaptive physiology through immediate effects primes responses prospective that will only appear at daytime, when absent. Similarly, annual history central nervous/endocrine system seasons come. Remarkably, maternal programs fetuses' behavior cope with cycle season after birth. These unique turn into biological time-domain–acting molecule. review focuses above considerations, proposes putative classification clinical dysfunctions, discusses general guidelines therapeutic use melatonin.

Language: Английский

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Clocking in to immunity

Nature reviews. Immunology, Journal Year: 2018, Volume and Issue: 18(7), P. 423 - 437

Published: April 16, 2018

Language: Английский

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Host and Environmental Factors Influencing Individual Human Cytokine Responses

Cell, Journal Year: 2016, Volume and Issue: 167(4), P. 1111 - 1124.e13

Published: Nov. 1, 2016

Language: Английский

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