IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation DOI
Peyton Conrey, Lidiya Denu, Kaitlin C. O’Boyle

et al.

Science Immunology, Journal Year: 2023, Volume and Issue: 8(83)

Published: May 26, 2023

The ability of most patients with selective immunoglobulin A (IgA) deficiency (SIgAD) to remain apparently healthy has been a persistent clinical conundrum. Compensatory mechanisms, including IgM, have proposed, yet it remains unclear how secretory IgA and IgM work together in the mucosal system and, on larger scale, whether systemic anti-commensal responses are redundant or unique features. To address this gap knowledge, we developed an integrated host-commensal approach combining microbial flow cytometry metagenomic sequencing (mFLOW-Seq) comprehensively define which microbes induce antibodies. We coupled high-dimensional immune profiling study cohort pediatric SIgAD household control siblings. found that antibody networks cooperate maintain homeostasis by targeting common subset commensal microbes. In IgA-deficiency, find increased translocation specific bacterial taxa associated elevated levels IgG fecal microbiota. Associated features dysregulation IgA-deficient mice humans included inflammatory cytokines, enhanced follicular CD4 T helper cell frequency activation, altered CD8 activation state. Although is clinically defined absence serum IgA, symptomatology were concentrated participants who also deficient. These findings reveal leads aberrant exposures microbes, increase likelihood humoral cellular symptomatic disease deficiency.

Language: Английский

Handbook of Religion and Health DOI
Harold G. Koenig, Tyler J. VanderWeele, John R. Peteet

et al.

Oxford University Press eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 23, 2023

Abstract The 2001 (first) edition of this Handbook was a comprehensive review history, research, and discussions on religion health through the year 2000. Appendix listed 1,200 separate quantitative studies each rated in quality 0–10 scale, followed by about 2,000 references an extensive index for rapid topic identification. 2012 (second) systematically updated research from 2000 to 2010, with number then reaching thousands. This 2023 (third) is most scientifically rigorous date, covering best published 2021 emphasis prospective randomized controlled trials. Beginning Foreword Dr. Howard K. Koh, former US Assistant Secretary Health Department Human Services, nearly 600,000-word volume examines almost every aspect health, reviewing past more recent relationship between outcomes. Furthermore, all its 34 chapters conclude clinical community applications, making text relevant both healthcare professionals (physicians, nurses, social workers, rehabilitation therapists, counselors, psychologists, sociologists, etc.) clergy (community clergy, chaplains, pastoral etc.). book’s focuses studies, describing study single line, allowing researchers quickly locate existing research. It should not be surprising that two decades has been cited health.

Language: Английский

Citations

1056
ImmuCellAI: A Unique Method for Comprehensive T‐Cell Subsets Abundance Prediction and its Application in Cancer Immunotherapy DOI Creative Commons
Ya‐Ru Miao, Qiong Zhang, Qian Lei

et al.

Advanced Science, Journal Year: 2020, Volume and Issue: 7(7)

Published: Feb. 11, 2020

The distribution and abundance of immune cells, particularly T-cell subsets, play pivotal roles in cancer immunology therapy. T cells have many subsets with specific function current methods are limited estimating them, thus, a method for predicting comprehensive is urgently needed research. Here, Immune Cell Abundance Identifier (ImmuCellAI), gene set signature-based method, introduced precisely the 24 cell types including 18 from expression data. Performance evaluation on both sequencing data flow cytometry results public indicate that ImmuCellAI can estimate superior accuracy to other especially subsets. Application immunotherapy datasets reveals dendritic cytotoxic T, gamma delta significantly higher comparisons on-treatment versus pre-treatment responders non-responders. Meanwhile, an result-based model built response high (area under curve 0.80-0.91). These demonstrate powerful unique tumor infiltration estimation prediction.

Language: Английский

Citations

766
Immune Function and Micronutrient Requirements Change over the Life Course DOI Open Access

Silvia Maggini,

Adeline Pierre,

Philip C. Calder

et al.

Nutrients, Journal Year: 2018, Volume and Issue: 10(10), P. 1531 - 1531

Published: Oct. 17, 2018

As humans age, the risk and severity of infections vary in line with immune competence according to how system develops, matures, declines. Several factors influence its competence, including nutrition. A bidirectional relationship among nutrition, infection immunity exists: changes one component affect others. For example, distinct features present during each life stage may type, prevalence, infections, while poor nutrition can compromise function increase risk. Various micronutrients are essential for immunocompetence, particularly vitamins A, C, D, E, B2, B6, B12, folic acid, iron, selenium, zinc. Micronutrient deficiencies a recognized global public health issue, nutritional status predisposes certain infections. Immune be improved by restoring deficient recommended levels, thereby increasing resistance supporting faster recovery when infected. Diet alone insufficient tailored micronutrient supplementation based on specific age-related needs necessary. This review looks at considerations stage, consequent infection, requirements exhibited over course, available evidence regarding effects infection.

Language: Английский

Citations

628
Stereotypic Immune System Development in Newborn Children DOI Creative Commons
Axel Olin, Ewa Henckel, Yang Chen

et al.

Cell, Journal Year: 2018, Volume and Issue: 174(5), P. 1277 - 1292.e14

Published: Aug. 1, 2018

Epidemiological data suggest that early life exposures are key determinants of immune-mediated disease later in life. Young children also particularly susceptible to infections, warranting more analyses immune system development Such mostly have been performed mouse models or human cord blood samples, but these cannot account for the complex environmental influencing newborns after birth. Here, we longitudinal 100 newborn children, sampled up 4 times during their first 3 months From μL blood, analyze 58 cell populations by mass cytometry and 267 plasma proteins immunoassays, uncovering drastic changes not predictable from measurements following a stereotypic pattern. Preterm term differ at birth converge onto shared trajectory, seemingly driven microbial interactions hampered gut bacterial dysbiosis.

Language: Английский

Citations

586
Physical Activity and Sports—Real Health Benefits: A Review with Insight into the Public Health of Sweden DOI Creative Commons
Christer Malm, Johan Jakobsson,

Andreas Isaksson

et al.

Sports, Journal Year: 2019, Volume and Issue: 7(5), P. 127 - 127

Published: May 23, 2019

Positive effects from sports are achieved primarily through physical activity, but secondary bring health benefits such as psychosocial and personal development less alcohol consumption. Negative effects, the risk of failure, injuries, eating disorders, burnout, also apparent. Because activity is increasingly conducted in an organized manner, sport’s role society has become important over years, not only for individual public health. In this paper, we intend to describe physiological benefits, stemming both sport participation per se. This narrative review summarizes research presents health-related data Swedish authorities. It discussed that our daily lives becoming physically active, while exercise training increases. Average energy intake increasing, creating surplus, thus, seeing increasing number people who overweight, which a strong contributor problems. Physical have significant positive preventing or alleviating mental illness, including depressive symptoms anxiety- stress-related disease. conclusion, can be evolving, if capacities, social situation, biological psychological maturation taken into account. Evidence suggests dose–response relationship being even modest level, superior inactive sedentary. Recommendations healthy summarized.

Language: Английский

Citations

482
A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring DOI

Ayelet Alpert,

Yishai Pickman, Michael D. Leipold

et al.

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(3), P. 487 - 495

Published: March 1, 2019

Language: Английский

Citations

397
Systemic and mucosal antibody responses specific to SARS-CoV-2 during mild versus severe COVID-19 DOI Creative Commons
Carlo Cervia, Jakob Nilsson, Yves Zurbuchen

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2020, Volume and Issue: 147(2), P. 545 - 557.e9

Published: Nov. 20, 2020

BackgroundWhereas severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody tests are increasingly being used to estimate the prevalence of SARS-CoV-2 infection, determinants these responses remain unclear.ObjectivesOur aim was evaluate systemic and mucosal toward in mild versus disease 2019 (COVID-19) cases.MethodsUsing immunoassays specific for spike proteins, we determined SARS-CoV-2–specific IgA IgG sera fluids cohorts, including PCR-positive patients (n = 64) PCR-negtive health care workers 109).ResultsSARS-CoV-2–specific serum titers with COVID-19 were often transiently positive, whereas remained negative or became positive 12 14 days after symptom onset. Conversely, showed a highly significant increase Very high correlated distress syndrome. Interestingly, some virus-neutralizing capacity cases. nasal inversely age.ConclusionsSystemic production against develops mainly COVID-19, very seen syndrome, may be associated transient antibodies but stimulate secretion. Whereas unclear. Our Using 109). age. Systemic

Language: Английский

Citations

389
Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease DOI
Seyhan Yazar, José Alquicira-Hernández, Kristof Wing

et al.

Science, Journal Year: 2022, Volume and Issue: 376(6589)

Published: April 7, 2022

The human immune system displays substantial variation between individuals, leading to differences in susceptibility autoimmune disease. We present single-cell RNA sequencing (scRNA-seq) data from 1,267,758 peripheral blood mononuclear cells 982 healthy subjects. For 14 cell types, we identified 26,597 independent cis-expression quantitative trait loci (eQTLs) and 990 trans-eQTLs, with most showing type-specific effects on gene expression. subsequently show how eQTLs have dynamic allelic B that are transitioning naïve memory states demonstrate commonly segregating alleles lead interindividual function. Finally, using a Mendelian randomization approach, identify the causal route by which 305 risk contribute disease at cellular level. This work brings together genetic epidemiology scRNA-seq uncover drivers of system.

Language: Английский

Citations

342
Cancer immunotherapy: a brief review of the history, possibilities, and challenges ahead DOI Open Access

Stanley J. Oiseth,

Mohamed Aziz

Journal of Cancer Metastasis and Treatment, Journal Year: 2017, Volume and Issue: 3(10), P. 250 - 250

Published: Oct. 31, 2017

The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis treatment, including the occurrence, development, progression, metastasis, treatment oncologic disease. It covers basic, translational clinical research related to cell biology, genomics, precision medicine, oncology internal radiotherapy radiology, obstetrics gynecology, pediatrics, surgery, hematology, neurooncology, etc.

Language: Английский

Citations

303
Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging DOI Creative Commons

Peggie Cheung,

Francesco Vallania, Hayley Warsinske

et al.

Cell, Journal Year: 2018, Volume and Issue: 173(6), P. 1385 - 1397.e14

Published: April 26, 2018

Language: Английский

Citations

295