The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression DOI Creative Commons

Émilie Boone,

Julien Colombani, Ditte S. Andersen

et al.

Nature Communications, Journal Year: 2016, Volume and Issue: 7(1)

Published: Nov. 22, 2016

Abstract Coordination of organ growth during development is required to generate fit individuals with fixed proportions. We recently identified Drosophila Dilp8 as a key hormone in coupling animal maturation. In addition, dilp8 mutant flies exhibit elevated fluctuating asymmetry (FA) demonstrating function for ensuring developmental stability. The signals regulating activity normal are not yet known. Here, we show that the transcriptional co-activators Hippo (Hpo) pathway, Yorkie (Yki, YAP/TAZ) and its DNA-binding partner Scalloped (Sd), directly regulate expression through Hpo-responsive element (HRE) promoter. further demonstrate mutation HRE by genome-editing results animals increased FA, thereby mimicking full loss function. Therefore, our indicate coordination organs connected their status feedback loop involving Hpo signalling pathways.

Language: Английский

Hormonal axes in Drosophila: regulation of hormone release and multiplicity of actions DOI Creative Commons
Dick R. Nässel, Meet Zandawala

Cell and Tissue Research, Journal Year: 2020, Volume and Issue: 382(2), P. 233 - 266

Published: Aug. 22, 2020

Hormones regulate development, as well many vital processes in the daily life of an animal. Many these hormones are peptides that act at a higher hierarchical level animal with roles organizers globally orchestrate metabolism, physiology and behavior. Peptide can on multiple peripheral targets simultaneously convey basal states, such metabolic status sleep-awake or arousal across central neuronal circuits. Thereby, they coordinate responses to changing internal external environments. The activity neurosecretory cells is controlled either by (1) cell autonomous sensors, (2) other neurons relay signals from sensors tissues (3) feedback target cells. Thus, hormonal signaling axis commonly comprises several components. In mammals vertebrates, axes known, hypothalamic-pituitary-gonad hypothalamic-pituitary-thyroid reproduction respectively. It has been proposed basic organization evolutionarily old cellular homologs hypothalamic-pituitary system be found for instance insects. To obtain appreciation similarities between insect vertebrate axes, we review systems Drosophila. Our outlines major peptidergic pathways known Drosophila presents set schemes orchestrating systems. detailed larval adult displays only very those arthropods vertebrates.

Language: Английский

Citations

89
A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae DOI Creative Commons
Bibi Nusreen Imambocus, Fangmin Zhou, A. Formozov

et al.

Current Biology, Journal Year: 2021, Volume and Issue: 32(1), P. 149 - 163.e8

Published: Nov. 18, 2021

Language: Английский

Citations

83
Tumour–host interactions through the lens of Drosophila DOI
David Bilder, Katy Ong, Tsai‐Ching Hsi

et al.

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(11), P. 687 - 700

Published: Aug. 13, 2021

Language: Английский

Citations

66
Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain DOI Open Access
Eunbyul Yeom, Hyemi Shin, Wonbeak Yoo

et al.

Nature Cell Biology, Journal Year: 2021, Volume and Issue: 23(2), P. 172 - 183

Published: Feb. 1, 2021

Language: Английский

Citations

58
Regulation of ecdysone production in Drosophila by neuropeptides and peptide hormones DOI Creative Commons

Jade R. Kannangara,

Christen K. Mirth, Coral G. Warr

et al.

Open Biology, Journal Year: 2021, Volume and Issue: 11(2)

Published: Feb. 1, 2021

In both mammals and insects, steroid hormones play a major role in directing the animal's progression through developmental stages. To maximize fitness outcomes, hormone production is regulated by environmental conditions experienced animal. ecdysone mediates transitions between stages response to factors such as nutrition. These signals are communicated ecdysone-producing gland via action of neuropeptide peptide signalling pathways. While some these pathways have been well characterized, there evidence suggest more than has previously thought function control production, potentially greater range conditions. Here, we review known regulate model genetic insect Drosophila melanogaster , what regarding that trigger Areas for future research highlighted can further contribute our overall understanding complex orchestration environmental, physiological cues together produce functioning adult organism.

Language: Английский

Citations

58
Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing DOI Open Access

MaryJane Shimell,

Xueyang Pan, Francisco A. Martín

et al.

Development, Journal Year: 2018, Volume and Issue: 145(6)

Published: Feb. 22, 2018

Adult size and fitness are controlled by a combination of genetics environmental cues. In Drosophila, growth is confined to the larval phase final body impacted duration this phase, which under neuroendocrine control. The neuropeptide prothoracicotropic hormone (PTTH) has been proposed play central role in controlling length through regulation ecdysone production, steroid that initiates molting metamorphosis. Here, we test examining consequences null mutations Ptth gene for Drosophila development. Loss causes several developmental defects, including delay timing, increase critical weight, loss coordination between imaginal disc growth, reduced adult survival suboptimal conditions such as nutritional deprivation or high population density. These defects caused decrease production associated with altered transcription biosynthetic genes. Therefore, PTTH signal contributes cues program ensure individual survival.

Language: Английский

Citations

83
Imaginal disc regeneration takes flight DOI
Iswar K. Hariharan, Florenci Serras

Current Opinion in Cell Biology, Journal Year: 2017, Volume and Issue: 48, P. 10 - 16

Published: April 1, 2017

Language: Английский

Citations

71
The biology and evolution of the Dilp8-Lgr3 pathway: A relaxin-like pathway coupling tissue growth and developmental timing control DOI Creative Commons
Alisson M. Gontijo, Andrés Garelli

Mechanisms of Development, Journal Year: 2018, Volume and Issue: 154, P. 44 - 50

Published: April 30, 2018

Language: Английский

Citations

62
The Corazonin-PTTH Neuronal Axis Controls Systemic Body Growth by Regulating Basal Ecdysteroid Biosynthesis in Drosophila melanogaster DOI Creative Commons
Eisuke Imura, Yuko Shimada‐Niwa, T. Nishimura

et al.

Current Biology, Journal Year: 2020, Volume and Issue: 30(11), P. 2156 - 2165.e5

Published: May 7, 2020

Steroid hormones play key roles in development, growth, and reproduction various animal phyla [1Miller W.L. Auchus R.J. The molecular biology, biochemistry, physiology of human steroidogenesis its disorders.Endocr. Rev. 2011; 32: 81-151Crossref PubMed Scopus (1369) Google Scholar]. insect steroid hormone, ecdysteroid, coordinates growth maturation, represented by molting metamorphosis [2Niwa R. Niwa Y.S. Enzymes for ecdysteroid biosynthesis: their biological functions insects beyond.Biosci. Biotechnol. Biochem. 2014; 78: 1283-1292Crossref (148) In Drosophila melanogaster, the prothoracicotropic hormone (PTTH)-producing neurons stimulate peak levels biosynthesis maturation [3McBrayer Z. Ono H. Shimell M. Parvy J.-P. Beckstead R.B. Warren J.T. Thummel C.S. Dauphin-Villemant C. Gilbert L.I. O'Connor M.B. Prothoracicotropic regulates developmental timing body size Drosophila.Dev. Cell. 2007; 13: 857-871Abstract Full Text PDF (316) Additionally, recent studies on PTTH signaling indicated that basal negatively affect systemic prior to [4Colombani J. Bianchini L. Layalle S. Pondeville E. Antoniewski Carré Noselli Léopold P. Antagonistic actions ecdysone insulins determine final Drosophila.Science. 2005; 310: 667-670Crossref (464) Scholar, 5Delanoue Slaidina controls repressing dMyc function fat cells.Dev. 2010; 18: 1012-1021Abstract (134) 6Boulan Martín D. Milán bantam miRNA promotes connecting insulin production.Curr. Biol. 2013; 23: 473-478Abstract (68) 7Boulan control growth.Cold Spring Harb. Perspect. 2015; 7: a019117PubMed 8Moeller M.E. Nagy Gerlach S.U. Soegaard K.C. Danielsen E.T. Texada M.J. Rewitz K.F. Warts organ through regulation ecdysone.Curr. 2017; 27: 1652-1659.e4Abstract (31) However, it remains unclear how is regulated biosynthesis. Here, we report Corazonin (Crz)-producing regulate affecting neurons. Crz belongs gonadotropin-releasing (GnRH) superfamily, implying an analogous role [9Zandawala Tian Elphick M.R. evolution nomenclature GnRH-type corazonin-type neuropeptide systems.Gen. Comp. Endocrinol. 2018; 264: 64-77Crossref (59) Inhibition neuronal activity increased pupal size, whereas hardly affected pupariation timing. This phenotype resulted from enhanced rate a delay elevation during mid-third instar larval (L3) stage. Interestingly, receptor (CrzR) expression was higher mid- than late-L3 Silencing CrzR phenocopying inhibition activity. When were optogenetically activated, strong calcium response observed mid-L3, but not late-L3, Furthermore, found octopamine contact subesophageal zone (SEZ), transmitting signals growth. Together, our results suggest Crz-PTTH axis modulates octopamine, uncovering regulatory neuroendocrine system transition maturation.

Language: Английский

Citations

61
Endocrine regulation of immunity in insects DOI Open Access
Catarina Nunes, Élio Sucena, Takashi Koyama

et al.

FEBS Journal, Journal Year: 2020, Volume and Issue: 288(13), P. 3928 - 3947

Published: Oct. 6, 2020

Organisms have constant contact with potentially harmful agents that can compromise their fitness. However, most of the times these fail to cause serious disease by virtue rapid and efficient immune responses elicited in host range from behavioural adaptations system triggering. The insects does not comprise adaptive arm, making it less complex than vertebrates, but key aspects activation regulation innate immunity are conserved across different phyla. This is case for hormonal as a part broad organismal external conditions under internal states. In insects, depending on physiological circumstances, distinct hormones either enhance or suppress response integrating individual (and often collective) physiologically behaviourally. this review, we provide an overview our current knowledge endocrine its mechanisms implications metabolic adaptation behaviour. We highlight importance multilayered survival reproduction (fitness) dependence integration other life‐history traits.

Language: Английский

Citations

57