The Atlas of Inflammation Resolution (AIR) DOI Creative Commons
Charles N. Serhan, Shailendra K. Gupta, Mauro Perretti

et al.

Molecular Aspects of Medicine, Journal Year: 2020, Volume and Issue: 74, P. 100894 - 100894

Published: Aug. 1, 2020

Acute inflammation is a protective reaction by the immune system in response to invading pathogens or tissue damage. Ideally, should be localized, self-limited, and returning homeostasis. If not resolved, acute can result organ pathologies leading chronic inflammatory phenotypes. resolution are complex coordinated processes, involving number of cell types, interacting space time. The biomolecular complexity fact that several biomedical fields involved, make multi- interdisciplinary approach necessary. Atlas Inflammation Resolution (AIR) web-based resource capturing an essential part state-of-the-art research. AIR provides interface for users search thousands interactions, arranged inter-connected multi-layers process diagrams, covering wide range clinically relevant By mapping experimental data onto AIR, it used elucidate drug action as well molecular mechanisms underlying different disease For visualization exploration information, uses Minerva platform, which well-established tool presentation maps. details encoded using international standards. was created freely accessible resource, supporting research education resolution. connects communities, facilitates clinical decision making, supports scientists formulation validation hypotheses. through https://air.bio.informatik.uni-rostock.de

Language: Английский

Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity DOI
Herbert Tilg, Timon E. Adolph, Michael Dudek

et al.

Nature Metabolism, Journal Year: 2021, Volume and Issue: 3(12), P. 1596 - 1607

Published: Dec. 20, 2021

Language: Английский

Citations

305
Hemicyanine‐Based Near‐Infrared Activatable Probes for Imaging and Diagnosis of Diseases DOI

Ziling Zeng,

Si Si Liew, Xin Wei

et al.

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(51), P. 26454 - 26475

Published: July 15, 2021

Molecular activatable probes with near-infrared (NIR) fluorescence play a critical role in vivo imaging of biomarkers for drug screening and disease diagnosis. With structural diversity high quantum yields, hemicyanine dyes have emerged as versatile scaffold the construction optical probes. This Review presents survey hemicyanine-based NIR (HNAPs) early diagnosis diseases. The molecular design principles HNAPs towards signaling against various are discussed focus on their broad applications detection diseases including inflammation, acute organ failure, skin diseases, intestinal cancer. progress not only proves unique value preclinical research but also highlights translational potential clinical

Language: Английский

Citations

249
Anakinra Therapy for Non-cancer Inflammatory Diseases DOI Creative Commons
Giulio Cavalli, Charles A. Dinarello

Frontiers in Pharmacology, Journal Year: 2018, Volume and Issue: 9

Published: Nov. 6, 2018

Interleukin-1 (IL-1) is the prototypic inflammatory cytokine: two distinct ligands (IL-1α and IL-1β) bind IL-1 type 1 receptor (IL-1R1) induce a myriad of secondary mediators, including prostaglandins, cytokines chemokines. IL-1α constitutively present in endothelial epithelial cells whereas IL-1β inducible myeloid released following cleavage by caspase 1. Over past 30 years, IL-1-mediated inflammation has been established broad spectrum diseases, ranging from rare autoinflammatory diseases to common conditions such as gout rheumatoid arthritis, 2 diabetes, atherosclerosis, acute myocardial infarction. Blocking IL entered clinical arena with anakinra, recombinant form naturally occurring Receptor antagonist (IL 1Ra); 1Ra prevents binding 1α well 1β 1R1. Quenching 1-mediated detrimental consequences tissue damage organ dysfunction. Although anakinra presently approved for treatment arthritis cryopyrin-associated periodic syndromes, off-label use far exceeds its indications. Dosing 100 mg subcutaneously provides clinically evident benefits within days some used daily over 12 years. Compared other biologics, an unparalleled record safety opportunistic infections, particularly Mycobacterium tuberculosis are rare, even populations at risk reactivation latent infections. Because this excellent profile relative short duration action, can also be diagnostic tool undefined mediated trials treat cancer, review focuses on chronic diseases.

Language: Английский

Citations

245
The impact of the Fungus-Host-Microbiota interplay uponCandida albicansinfections: current knowledge and new perspectives DOI Creative Commons
Christophe d’Enfert,

Ann-Kristin Kaune,

Leovigildo-Rey Alaban

et al.

FEMS Microbiology Reviews, Journal Year: 2020, Volume and Issue: 45(3)

Published: Nov. 18, 2020

Candida albicans is a major fungal pathogen of humans. It exists as commensal in the oral cavity, gut or genital tract most individuals, constrained by local microbiota, epithelial barriers and immune defences. Their perturbation can lead to outgrowth development mucosal infections such oropharyngeal vulvovaginal candidiasis, patients with compromised immunity are susceptible life-threatening systemic infections. The importance interplay between fungus, host microbiota driving transition from C. commensalism pathogenicity widely appreciated. However, complexity these interactions, significant impact fungal, variability upon disease severity outcome, less well understood. Therefore, we summarise features fungus that promote infection, how genetic variation clinical isolates influences pathogenicity. We discuss antifungal immunity, this differs mucosae, individual person's susceptibility infection. Also, describe factors influence composition gut, vaginal microbiotas, affect colonisation immunity. argue detailed understanding variables, which underlie fungal-host-microbiota will present opportunities for directed therapies benefit vulnerable patients.

Language: Английский

Citations

238
Gut Microbiota Interact With the Brain Through Systemic Chronic Inflammation: Implications on Neuroinflammation, Neurodegeneration, and Aging DOI Creative Commons

Yi Mou,

Yu Du, Lixing Zhou

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: April 7, 2022

It has been noticed in recent years that the unfavorable effects of gut microbiota could exhaust host vigor and life, yet knowledge theory are just beginning to be established. Increasing documentation suggests microbiota–gut–brain axis not only impacts brain cognition psychiatric symptoms but also precipitates neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS). How blood–brain barrier (BBB), a machinery protecting central nervous system (CNS) from systemic circulation, allows risky factors derived translocated into seems paradoxical. For unique anatomical, histological, immunological properties underpinning its permeable dynamics, BBB regarded biomarker associated with neural pathogenesis. The permeability mice rats caused by GM dysbiosis raises question how metabolites change causes pathophysiology neuroinflammation neurodegeneration (NF&ND) aging, pivotal multidisciplinary field tightly immune chronic inflammation. If all, microbiota-induced inflammation (GM-SCI) mainly refers excessive mucosal immunity dysregulation, which is often influenced dietary components age, produced at interface intestinal (IB) or exacerbated after IB disruption, initiates various common diseases along dispersal routes, eventually impairs integrity cause NF&ND aging. To illustrate roles affected inflammatory “leaky” resulting their metabolites, we reviewed selected publications, including role barrier, influences on permeability, NF&ND, add depth bridging inflammation, plausible mechanism indispensable for corruption was highlighted; namely, maintenance cues cytokines, may help understand play major

Language: Английский

Citations

220
From Focal Lipid Storage to Systemic Inflammation DOI
Peter Libby, Göran K. Hansson

Journal of the American College of Cardiology, Journal Year: 2019, Volume and Issue: 74(12), P. 1594 - 1607

Published: Sept. 1, 2019

Language: Английский

Citations

216
The Role of Mitophagy in Innate Immunity DOI Creative Commons
Ilias Gkikas, Konstantinos Palikaras, Nektarios Tavernarakis

et al.

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 9

Published: June 5, 2018

Mitochondria are cellular organelles essential for multiple biological processes, including energy production, metabolites biosynthesis, cell death and immunological responses among others. Recent advances in the field of immunology research reveal pivotal role metabolism innate immune cells fate function. Therefore, maintenance mitochondrial network integrity activity is a prerequisite system homeostasis. Mitochondrial selective autophagy, known as mitophagy, surveils population eliminating superfluous and/or impaired mediating survival viability response to injury/trauma infection. Defective removal damaged mitochondria leads hyperactivation inflammatory signaling pathways subsequently chronic systemic inflammation development diseases. Here, we review molecular mechanisms mitophagy highlight its critical

Language: Английский

Citations

199
Mediators of Inflammation DOI
Izabela Galvão, Michelle A. Sugimoto, Juliana P. Vago

et al.

Springer eBooks, Journal Year: 2018, Volume and Issue: unknown, P. 3 - 32

Published: Jan. 1, 2018

Language: Английский

Citations

189
Mitochondria in the signaling pathways that control longevity and health span DOI Creative Commons
Mansour Akbari, Thomas B. L. Kirkwood, Vilhelm A. Bohr

et al.

Ageing Research Reviews, Journal Year: 2019, Volume and Issue: 54, P. 100940 - 100940

Published: Aug. 12, 2019

Genetic and pharmacological intervention studies have identified evolutionarily conserved functionally interconnected networks of cellular energy homeostasis, nutrient-sensing, genome damage response signaling pathways, as prominent regulators longevity health span in various species. Mitochondria are the primary sites ATP production key players several other important processes. Mitochondrial dysfunction diminishes tissue organ functional performance is a commonly considered feature aging process. Here we review evidence that through reciprocal multilevel interactions, mitochondria implicated lifespan modulation function these which altogether constitute highly dynamic complex system controls An characteristic pathways their extensive crosstalk apparent malleability to modification by non-invasive pharmacological, dietary, lifestyle interventions, with promising effects on animal models potentially also humans.

Language: Английский

Citations

170
Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming DOI Open Access
Jack Green, Yu Shi, Fatima Martín‐Sánchez

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2018, Volume and Issue: 115(40)

Published: Sept. 19, 2018

The NLRP3 inflammasome is an important regulator of inflammation and immunity. It a multimolecular platform formed within cells that facilitates the activation proinflammatory caspases to drive secretion cytokines such as interleukin-1β (IL-1β). Knowledge mechanisms regulating formation incomplete. Here we report Cl- channel-dependent dynamic ASC oligomers specks remain inactive in absence K+ efflux. Formed after efflux exclusively, are dependent, reversible, inactive, although they further prime inflammatory responses, accelerating enhancing release IL-1β response efflux-inducing stimulus. NEK7 specific sensor does not associate with under conditions stimulating exclusively efflux, but activating complex driving inflammation. Our investigation delivers mechanistic understanding into regulation responses.

Language: Английский

Citations

167