The Cytokines of Asthma

Immunity, Journal Year: 2019, Volume and Issue: 50(4), P. 975 - 991

Published: April 1, 2019

Language: Английский

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The basic immunology of asthma

Cell, Journal Year: 2021, Volume and Issue: 184(6), P. 1469 - 1485

Published: March 1, 2021

Language: Английский

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Allergic inflammatory memory in human respiratory epithelial progenitor cells

Nature, Journal Year: 2018, Volume and Issue: 560(7720), P. 649 - 654

Published: Aug. 1, 2018

Language: Английский

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The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis

Nature Immunology, Journal Year: 2018, Volume and Issue: 19(12), P. 1286 - 1298

Published: Nov. 8, 2018

Language: Английский

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Environmental exposures and mechanisms in allergy and asthma development

Journal of Clinical Investigation, Journal Year: 2019, Volume and Issue: 129(4), P. 1504 - 1515

Published: Feb. 10, 2019

Environmental exposures interplay with human host factors to promote the development and progression of allergic diseases. The worldwide prevalence disease is rising as a result complex gene-environment interactions that shape immune system response. Research shows an association between rise diseases increasingly modern Westernized lifestyles, which are characterized by increased urbanization, time spent indoors, antibiotic usage. These environmental changes in exposure air traffic pollution, fungi, infectious agents, tobacco smoke, other early-life lifelong risk for exacerbation asthma It recognized timing, load, route allergen affect phenotypes development. Still, our ability prevent hindered gaps understanding underlying mechanisms interaction environmental, viral, pathways impact This Review highlights epidemiologic mechanistic evidence linking airway responses.

Language: Английский

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Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches

Immunity, Journal Year: 2019, Volume and Issue: 50(3), P. 707 - 722.e6

Published: Feb. 26, 2019

Language: Английский

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A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity

Cell Host & Microbe, Journal Year: 2018, Volume and Issue: 25(1), P. 113 - 127.e6

Published: Dec. 20, 2018

Language: Английский

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Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming

Immunity, Journal Year: 2019, Volume and Issue: 50(6), P. 1425 - 1438.e5

Published: May 22, 2019

Language: Английский

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A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes

Nature Immunology, Journal Year: 2017, Volume and Issue: 18(12), P. 1310 - 1320

Published: Oct. 16, 2017

Language: Английский

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Probiotics in Disease Prevention and Treatment

The Journal of Clinical Pharmacology, Journal Year: 2018, Volume and Issue: 58(S10)

Published: Sept. 24, 2018

Few treatments for human diseases have received as much investigation in the past 20 years probiotics. In 2017, English-language meta-analyses totaling 52 studies determined effect of probiotics on conditions ranging from necrotizing enterocolitis and colic infants to constipation, irritable bowel syndrome, hepatic encephalopathy adults. The strongest evidence favor lies prevention or treatment 5 disorders: enterocolitis, acute infectious diarrhea, respiratory tract infections, antibiotic-associated infant colic. Probiotic mechanisms action include inhibition bacterial adhesion; enhanced mucosal barrier function; modulation innate adaptive immune systems (including induction tolerogenic dendritic cells regulatory T cells); secretion bioactive metabolites; regulation enteric central nervous systems. Future research is needed identify optimal probiotic dose specific diseases, address whether addition prebiotics (to form synbiotics) would enhance activity, determine if defined microbial communities provide benefit exceeding that single-species

Language: Английский

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