Astrocyte Crosstalk in CNS Inflammation

Neuron, Journal Year: 2020, Volume and Issue: 108(4), P. 608 - 622

Published: Sept. 7, 2020

Language: Английский

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From neural development to cognition: unexpected roles for chromatin

Nature Reviews Genetics, Journal Year: 2013, Volume and Issue: 14(5), P. 347 - 359

Published: April 9, 2013

Language: Английский

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Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

Nature Neuroscience, Journal Year: 2015, Volume and Issue: 19(1), P. 40 - 47

Published: Nov. 30, 2015

Language: Английский

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Editing the epigenome: technologies for programmable transcription and epigenetic modulation

Nature Methods, Journal Year: 2016, Volume and Issue: 13(2), P. 127 - 137

Published: Jan. 28, 2016

Language: Английский

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SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

Nature Communications, Journal Year: 2014, Volume and Issue: 5(1)

Published: Sept. 23, 2014

Language: Английский

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Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions

Neuron, Journal Year: 2015, Volume and Issue: 86(6), P. 1343 - 1357

Published: June 1, 2015

Language: Английский

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The emerging field of epigenetics in neurodegeneration and neuroprotection

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(6), P. 347 - 361

Published: May 18, 2017

Language: Английский

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Use of Epigenetic Drugs in Disease: An Overview

Genetics & Epigenetics, Journal Year: 2014, Volume and Issue: 6

Published: Jan. 1, 2014

Epigenetic changes such as DNA methylation and histone acetylation alter gene expression at the level of transcription by upregulating, downregulating, or silencing genes completely. Dysregulation epigenetic events can be pathological, leading to cardiovascular disease, neurological disorders, metabolic cancer development. Therefore, identifying drugs that inhibit these are great clinical interest. In this review, we summarize associated with different disorders diseases including cardiovascular, neurological, cancer. Knowledge specific types facilitates development inhibitors, which used drugs. discuss major classes currently in use, inhibiting drugs, bromodomain acetyl transferase deacetylase protein methyltransferase inhibitors their role reversing treating disease.

Language: Английский

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Epigenetic Basis of Mental Illness

The Neuroscientist, Journal Year: 2015, Volume and Issue: 22(5), P. 447 - 463

Published: Oct. 9, 2015

Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in neural circuit structure and function as well likely abnormalities glial cells. While genetic factors important the etiology of most mental disorders, relatively high rates discordance among identical twins, particularly for depression other stress-related syndromes, clearly indicate importance additional mechanisms. Environmental such stress known to play a role onset these illnesses. Exposure environmental insults induces stable changes gene expression, function, ultimately behavior, maladaptations appear distinct between developmental versus adult exposures. Increasing evidence indicates that sustained maintained by epigenetic modifications specific brain regions. Indeed, transcriptional dysregulation aberrant regulation underlies this is unifying theme psychiatric disorders. Here, we provide progress report studies three major depression, schizophrenia, bipolar disorder. We review literature derived from animal models postmortem tissue human patients. illness remain at early stages, understanding how recruit machinery within regions cause lasting disease susceptibility pathophysiology revealing new insight into treatment conditions.

Language: Английский

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Methylomic trajectories across human fetal brain development

Genome Research, Journal Year: 2015, Volume and Issue: 25(3), P. 338 - 352

Published: Feb. 3, 2015

Epigenetic processes play a key role in orchestrating transcriptional regulation during development. The importance of DNA methylation fetal brain development is highlighted by the dynamic expression de novo methyltransferases perinatal period and neurodevelopmental deficits associated with mutations methyl-CpG binding protein 2 ( MECP2 ) gene. However, our knowledge about temporal changes to epigenome has, date, been limited. We quantified genome-wide patterns at ∼400,000 sites 179 human samples (100 male, 79 female) spanning 23 184 d post-conception. identified highly significant across >7% sites, an enrichment loci becoming hypomethylated age. Sites developmental were significantly underrepresented promoter regulatory regions but overrepresented flanking CpG islands (shores shelves) gene bodies. Highly differences observed between males females number autosomal small showing sex-specific trajectories Weighted comethylation network analysis (WGCNA) revealed discrete modules comethylated age that are enriched for genes involved processes. This is, knowledge, most extensive study confirming prenatal as time considerable epigenomic plasticity.

Language: Английский

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