Experimental & Molecular Medicine,
Journal Year:
2016,
Volume and Issue:
48(3), P. e215 - e215
Published: March 11, 2016
Adipose
tissue
is
a
highly
heterogeneous
endocrine
organ.
The
heterogeneity
among
different
anatomical
depots
stems
from
their
intrinsic
differences
in
cellular
and
physiological
properties,
including
developmental
origin,
adipogenic
proliferative
capacity,
glucose
lipid
metabolism,
insulin
sensitivity,
hormonal
control,
thermogenic
ability
vascularization.
Additional
factors
that
influence
adipose
are
genetic
predisposition,
environment,
gender
age.
Under
obese
condition,
these
depot-specific
translate
into
specific
fat
distribution
patterns,
which
closely
associated
with
differential
cardiometabolic
risks.
For
instance,
individuals
central
obesity
more
susceptible
to
developing
diabetes
cardiovascular
complications,
whereas
those
peripheral
metabolically
healthy.
This
review
summarizes
the
clinical
mechanistic
evidence
for
give
rise
metabolic
consequences,
provides
therapeutic
insights
targeted
treatment
of
obesity.
Investigations
needed
variety
white
deposits
body
on
obesity-related
health
problems.
Aimin
Xu
colleagues
at
University
Hong
Kong
reviewed
current
understanding
(fat)
how
it
behaves
parts
body.
known
be
diverse
composition,
its
properties
depending
large
cells
become
where
they
accumulate
People
'central
obesity'—extensive
abdominal
region—are
likely
develop
heart
problems,
example.
researchers
call
further
research
examining
associations
between
risks
hope
therapies
targeting
tissues
might
possibility.
Frontiers in Cardiovascular Medicine,
Journal Year:
2020,
Volume and Issue:
7
Published: Feb. 25, 2020
Adipose
tissue
plays
essential
roles
in
maintaining
lipid
and
glucose
homeostasis.
To
date
several
types
of
adipose
have
been
identified,
namely
white,
brown,
beige,
that
reside
various
specific
anatomical
locations
throughout
the
body.
The
cellular
composition,
secretome,
location
these
depots
define
their
function
health
metabolic
disease.
In
obesity,
becomes
dysfunctional,
promoting
a
pro-inflammatory,
hyperlipidemic
insulin
resistant
environment
contributes
to
type
2
diabetes
mellitus
(T2DM).
Concurrently,
similar
features
result
from
dysfunction
also
promote
cardiovascular
disease
(CVD)
by
mechanisms
can
be
augmented
T2DM.
which
dysfunctional
simultaneously
T2DM
CVD,
focusing
on
depot-specific
adipokines,
inflammatory
profiles,
metabolism,
will
focus
this
review.
impact
CVD
treatment
strategies
body
weight
discussed.
Endocrine Reviews,
Journal Year:
2018,
Volume and Issue:
39(4), P. 489 - 517
Published: April 24, 2018
The
ability
to
efficiently
adapt
metabolism
by
substrate
sensing,
trafficking,
storage,
and
utilization,
dependent
on
availability
requirement,
is
known
as
metabolic
flexibility.
In
this
review,
we
discuss
the
breadth
depth
of
flexibility
its
impact
health
disease.
Metabolic
essential
maintain
energy
homeostasis
in
times
either
caloric
excess
or
restriction,
low
high
demand,
such
during
exercise.
liver,
adipose
tissue,
muscle
govern
systemic
manage
nutrient
uptake,
transport,
expenditure
communication
via
endocrine
cues.
At
a
molecular
level,
relies
configuration
pathways,
which
are
regulated
key
enzymes
transcription
factors,
many
interact
closely
with
mitochondria.
Disrupted
flexibility,
inflexibility,
however,
associated
pathological
conditions
including
syndrome,
type
2
diabetes
mellitus,
cancer.
Multiple
factors
dietary
composition
feeding
frequency,
exercise
training,
use
pharmacological
compounds,
influence
will
be
discussed
here.
Last,
outline
important
advances
research
medical
horizons
translational
aspects.
