Trends in Neurosciences, Journal Year: 2015, Volume and Issue: 39(2), P. 54 - 62
Published: Dec. 30, 2015
Language: Английский
Annual Review of Entomology, Journal Year: 2013, Volume and Issue: 59(1), P. 165 - 184
Published: Oct. 25, 2013
The central complex is a group of modular neuropils across the midline insect brain. Hallmarks its anatomical organization are discrete layers, an into arrays 16 slices along right-left axis, and precise inter-hemispheric connections via chiasmata. connected most prominently with adjacent lateral superior protocerebrum. Its developmental appearance corresponds compound eyes walking legs. Distinct dopaminergic neurons control various forms arousal. Electrophysiological studies provide evidence for roles in polarized light vision, sky compass orientation, integration spatial information locomotor control. Behavioral on mutant transgenic flies indicate representation visual cues, memory, directional flight, place learning. data suggest that azimuthal directions (i.e., where) represented slices, cue what) different layers complex.
Language: Английский
Citations
372
Genetics, Journal Year: 2017, Volume and Issue: 205(4), P. 1373 - 1397
Published: March 30, 2017
The advantages of the model organism Drosophila melanogaster, including low genetic redundancy, functional simplicity, and ability to conduct large-scale screens, have been essential for understanding molecular nature circadian (∼24 hr) rhythms, continue be valuable in discovering novel regulators rhythms sleep. In this review, we discuss current these interrelated biological processes wider implications research. Clock genes period timeless were first discovered screens developed 1970s. Feedback on their own transcription forms core clock, accurately timed expression, localization, post-transcriptional modification, function is thought critical maintaining cycle. Regulators, several phosphatases kinases, act different steps feedback loop ensure strong rhythms. Approximately 150 neurons fly brain that contain components clock together translate intracellular cycling into rhythmic behavior. We how groups serve functions allowing clocks entrain environmental cues, driving behavioral outputs at times day, flexible responses conditions. neuropeptide PDF provides an important signal synchronize neurons, although details accomplishes are still being explored. Secreted signals from also influence other tissues. SLEEP is, part, regulated by which ensures appropriate timing sleep, but amount quality sleep determined mechanisms a homeostatic balance between wake. Flies useful identifying large set genes, molecules, neuroanatomic loci regulating amount. Conserved aspects regulation flies mammals include wake-promoting roles catecholamine neurotransmitters involvement hypothalamus-like regions, regions implicated less clear parallels. Sleep subject factors such as food availability, stress, social environment. beginning understand identified molecules interact with each other, environment, regulate researchers can take advantage increasing mechanistic behaviors, learning memory, courtship, aggression, loss impacts behaviors. thus remain tool both discovery deep
Language: Английский
Citations
372
Science, Journal Year: 2013, Volume and Issue: 340(6129), P. 157 - 161
Published: April 11, 2013
The arthropod central complex and vertebrate basal ganglia derive from embryonic forebrain lineages that are specified by an evolutionarily conserved genetic program leading to interconnected neuropils nuclei populate the midline of forebrain-midbrain boundary region. In substructures both ganglia, network connectivity neuronal activity mediate control mechanisms in which inhibitory (GABAergic) modulatory (dopaminergic) circuits facilitate regulation release adaptive behaviors. Both dysfunction result behavioral defects including motor abnormalities, impaired memory formation, attention deficits, affective disorders, sleep disturbances. observed multitude similarities suggests deep homology circuitries underlying selection maintenance actions.
Language: Английский
Citations
331
Cell, Journal Year: 2016, Volume and Issue: 165(6), P. 1347 - 1360
Published: May 21, 2016
Language: Английский
Citations
325
eLife, Journal Year: 2021, Volume and Issue: 10
Published: Oct. 26, 2021
Flexible behaviors over long timescales are thought to engage recurrent neural networks in deep brain regions, which experimentally challenging study. In insects, circuit dynamics a region called the central complex (CX) enable directed locomotion, sleep, and context- experience-dependent spatial navigation. We describe first complete electron microscopy-based connectome of
Language: Английский
Citations
304
Neuron, Journal Year: 2019, Volume and Issue: 101(5), P. 876 - 893.e4
Published: Feb. 21, 2019
Language: Английский
Citations
295
Neuron, Journal Year: 2014, Volume and Issue: 81(4), P. 860 - 872
Published: Feb. 1, 2014
Sleep is under homeostatic control, but the mechanisms that sense sleep need and correct deficits remain unknown. Here, we report sleep-promoting neurons with projections to dorsal fan-shaped body (FB) form output arm of Drosophila's homeostat. Homeostatic control requires Rho-GTPase-activating protein encoded by crossveinless-c (cv-c) gene in order transduce pressure into increased electrical excitability FB neurons. cv-c mutants exhibit decreased time, diminished rebound, memory comparable those after loss. Targeted ablation rescue Cv-c sleep-control impair restore, respectively, normal patterns. deprivation increases neurons, this adjustment disrupted short-sleeping mutants. thus shifts input-output function toward heightened activity modulating ion channel a mechanism dependent on Cv-c.
Language: Английский
Citations
275
Nature, Journal Year: 2016, Volume and Issue: 536(7616), P. 333 - 337
Published: Aug. 2, 2016
Language: Английский
Citations
265
Cell, Journal Year: 2015, Volume and Issue: 161(7), P. 1656 - 1667
Published: June 1, 2015
Early studies from psychology suggest that sleep facilitates memory retention by stopping ongoing retroactive interference caused mental activity or external sensory stimuli. Neuroscience research with animal models, on the other hand, suggests enhancing consolidation. Recently, in Drosophila, of specific dopamine neurons was shown to regulate forgetting olfactory memories. Here, we show this dopaminergic is modulated behavioral state, increasing robustly locomotor and decreasing rest. Increasing sleep-drive, either sleep-promoting agent Gaboxadol genetic stimulation neural circuit for sleep, decreases activity, while retention. Conversely, arousal stimulates accelerates dopaminergic-based forgetting. Therefore, regulated state modulation plasticity. Our findings integrate psychological neuroscience
Language: Английский
Citations
238
Science, Journal Year: 2019, Volume and Issue: 363(6426), P. 509 - 515
Published: Feb. 1, 2019
Sleep remains a major mystery of biology. In particular, little is known about the mechanisms that account for drive to sleep. an unbiased screen more than 12,000 Drosophila lines, we identified single gene, nemuri, induces The NEMURI protein antimicrobial peptide can be secreted ectopically prolonged sleep (with resistance arousal) and promote survival after infection. Loss nemuri increased arousability during daily attenuated acute increase in induced by deprivation or bacterial Conditions expression small number fly brain neurons targeted it sleep-promoting, dorsal fan-shaped body. We propose bona fide homeostasis factor particularly important under conditions high need; because these include sickness, our findings provide link between immune function.
Language: Английский
Citations
162