A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation

Cell, Journal Year: 2021, Volume and Issue: 184(12), P. 3222 - 3241.e26

Published: May 17, 2021

Language: Английский

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Novel electrode technologies for neural recordings

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(6), P. 330 - 345

Published: March 4, 2019

Language: Английский

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Navigating cognition: Spatial codes for human thinking

Science, Journal Year: 2018, Volume and Issue: 362(6415)

Published: Nov. 8, 2018

A framework for cognitive spaces Ever since Tolman's proposal of maps in the 1940s, question how spatial representations support flexible behavior has been a contentious topic. Bellmund et al. review and combine concepts from science philosophy with findings neurophysiology navigation rodents to propose neuroscience. They argue that spatial-processing principles hippocampalentorhinal region provide geometric code map information domains high-level cognition discuss recent evidence this proposal. Science , issue p. eaat6766

Language: Английский

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The Brain from Inside Out

Oxford University Press eBooks, Journal Year: 2019, Volume and Issue: unknown

Published: June 17, 2019

Abstract The Brain from Inside Out takes a critical look at contemporary brain research and reminds us that theoretical framework does matter. Current technology-driven neuroscience is still largely fueled by an empiricist philosophy assuming the brain’s goal to perceive, represent world, learn truth. An inevitable consequence of this assumption decision-making homunculus wedged between our perception actions. In contrast, advocates fundamental function induce actions predict consequences those support survival prosperity host. Brains constantly test their hypotheses producing rather than searching for veridical objective world. Only can provide second opinion about relevance sensory inputs meaning interpretation inputs. inside-out framework, it not sensations teach build up its circuits. Instead, comes with preconfigured self-organized dynamics constrains how acts views Both anatomical physiological organizations are characterized enormous diversity which spans several orders magnitude. two ends continuous landscape give rise apparently distinct qualitative features. A small core strongly interconnected, highly active neurons provides fast “good-enough” answers in needy situations generalizations, whereas detailed precise solutions rely on contribution more isolated sluggish majority. non-egalitarian organization, preexisting nonsense patterns become meaningful through action-based experience. offers alternative strategy investigate operations cognitive faculties, as opposed outside-in approach explores preconceived ideas map onto structures.

Language: Английский

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Egocentric coding of external items in the lateral entorhinal cortex

Science, Journal Year: 2018, Volume and Issue: 362(6417), P. 945 - 949

Published: Nov. 23, 2018

Egocentric representation of objects The lateral entorhinal cortex (LEC) and medial (MEC) are the two major cortical projections to hippocampus. discovery a variety functional cell types in MEC has greatly advanced our understanding anatomy entorhinal-hippocampal circuits. However, function LEC behavioral correlates cells still not fully understood. Wang et al. analyzed firing properties neurons. They found that used different reference frames, with encoding egocentrically. Science , this issue p. 945

Language: Английский

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The entorhinal cognitive map is attracted to goals

Science, Journal Year: 2019, Volume and Issue: 363(6434), P. 1443 - 1447

Published: March 28, 2019

Grid cells with their rigid hexagonal firing fields are thought to provide an invariant metric the hippocampal cognitive map, yet environmental geometrical features have recently been shown distort grid structure. Given that role goes beyond space, we tested influence of nonspatial information on organization. We trained rats daily learn three new reward locations a cheeseboard maze while recording from medial entorhinal cortex and CA1 region. Many moved toward goal location, leading long-lasting deformations map. Therefore, distortions in structure contribute representation during both learning recall, which demonstrates participate mnemonic coding do not merely simple space.

Language: Английский

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Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory

EXPERIMENTAL ANIMALS, Journal Year: 2022, Volume and Issue: 71(3), P. 264 - 280

Published: Jan. 1, 2022

Since its development about 40 years ago (1981–2021), Morris water maze has turned into a very popular tool for assessing spatial learning and memory. Its many advantages have ensured pertinence to date. These include effectiveness in evaluating hippocampal-dependent memory, exemption from motivational differences across diverse experimental manipulations, reliability various cross-species studies, adaptability conditions with test protocols. Nonetheless, throughout establishment, several analysis loopholes galvanized researchers assess ways which it could be improved adapted fill this gap. Therefore, review, we briefly summarize these developments since the early of establishment through most recent advancements computerized analysis, offering more comprehensive paradigms. In addition, discuss different versions paradigms, providing suggestions regard best paradigms particular conditions. Hence, proper selection protocols, consideration assay’s limitations should carefully considered. Given that appropriate measures are taken, adaptations made, will likely remain relevant mechanisms

Language: Английский

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Two views on the cognitive brain

Nature reviews. Neuroscience, Journal Year: 2021, Volume and Issue: 22(6), P. 359 - 371

Published: April 15, 2021

Language: Английский

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Neurons and networks in the entorhinal cortex: A reappraisal of the lateral and medial entorhinal subdivisions mediating parallel cortical pathways

Hippocampus, Journal Year: 2019, Volume and Issue: 29(12), P. 1238 - 1254

Published: Aug. 13, 2019

Abstract In this review, we aim to reappraise the organization of intrinsic and extrinsic networks entorhinal cortex with a focus on concept parallel cortical connectivity streams. The two areas, lateral medial cortex, belonging input–output streams mediating encoding storage respectively what where information hinges claim that major component their connections is perirhinal postrhinal or parahippocampal in, respectively, rodents primates. scenario, are connectionally associated likewise postrhinal/parahippocampal partners. contrast, here argue matrix emphasizes potential substantial integration through interactions between subdivisions cortices, but most importantly new observation projects both cortex. We suggest inputs provide hippocampus high‐order complex representations external environment, its stability, as well apparent changes either an inherent feature biological environment result navigating environment. This thus indicates current connectional model region part temporal lobe memory system needs be revised.

Language: Английский

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An Integrated Index: Engrams, Place Cells, and Hippocampal Memory

Neuron, Journal Year: 2020, Volume and Issue: 107(5), P. 805 - 820

Published: Aug. 6, 2020

Language: Английский

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