Social stress induces neurovascular pathology promoting depression

Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(12), P. 1752 - 1760

Published: Nov. 9, 2017

Language: Английский

---

Loneliness, Social Isolation, and Cardiovascular Health

Antioxidants and Redox Signaling, Journal Year: 2017, Volume and Issue: 28(9), P. 837 - 851

Published: Oct. 23, 2017

Social and demographic changes have led to an increased prevalence of loneliness social isolation in modern society. Recent Advances: Population-based studies demonstrated that both objective the perception (loneliness) are correlated with a higher risk mortality clearly factors for cardiovascular disease (CVD). Lonely individuals peripheral vascular resistance elevated blood pressure. Socially isolated animals develop more atherosclerosis than those housed groups.Molecular mechanisms responsible poorly understood. In recent reports, stress were associated activation hypothalamic-pituitary-adrenocortical axis sympathetic nervous system. Repeated chronic leads glucocorticoid resistance, enhanced myelopoiesis, upregulated proinflammatory gene expression, oxidative stress. However, causal role these development loneliness-associated CVD remains unclear.Elucidation molecular how is induced by requires additional studies. Understanding pathomechanisms essential therapeutic strategies prevent detrimental effects on health. Antioxid. Redox Signal. 28, 837-851.

Language: Английский

---

NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings

Brain Behavior and Immunity, Journal Year: 2017, Volume and Issue: 64, P. 367 - 383

Published: March 2, 2017

Language: Английский

---

Brain microglia in psychiatric disorders

The Lancet Psychiatry, Journal Year: 2017, Volume and Issue: 4(7), P. 563 - 572

Published: April 26, 2017

Language: Английский

---

Blood–Brain Barrier Dynamics to Maintain Brain Homeostasis

Trends in Neurosciences, Journal Year: 2021, Volume and Issue: 44(5), P. 393 - 405

Published: Jan. 8, 2021

The blood-brain barrier (BBB) is a dynamic platform for exchange of substances between the blood and brain parenchyma, it an essential functional gatekeeper central nervous system (CNS). While widely recognized that BBB disruption hallmark several neurovascular pathologies, aspect has received somewhat less attention modulation tightness to maintain homeostasis in response extrinsic environmental factors physiological changes. In this review, we summarize how integrity adjusts critical stages along life span, as well permeability can be altered by common stressors derived from nutritional habits, psychological stress.

Language: Английский

---

Aggression, Social Stress, and the Immune System in Humans and Animal Models

Frontiers in Behavioral Neuroscience, Journal Year: 2018, Volume and Issue: 12

Published: March 22, 2018

Social stress can lead to the development of psychological problems ranging from exaggerated anxiety and depression antisocial violence-related behaviors. Increasing evidence suggests that immune system is involved in responses social adulthood. For example, human studies show individuals with high aggression traits display heightened inflammatory cytokine levels dysregulated such as slower wound healing. Similar findings have been observed patients depression, comorbidity was correlated stronger dysregulation. Therefore, dysregulation may be one mediators produces and/or depression. humans, aggressive animals also increased several proinflammatory cytokines, however, unlike humans these are more protected infectious organisms faster healing than low aggression. On other hand, subordinate receive repeated defeat shown develop escalated glucocorticoid insensitivity monocytes. In this review we synthesize current non-human primates, rodents a role for leading psychiatric or We argue while represent two fundamentally different behavioral physiological stress, it possible some overlapped, well distinct, pattern signaling underlie both them. necessity studying animal models maladaptive induced by (i.e. isolation) understanding neuro-immune mechanism aggression, which relevant

Language: Английский

---

The role of neuro‐immune interactions in cancer‐related fatigue: Biobehavioral risk factors and mechanisms

Cancer, Journal Year: 2019, Volume and Issue: 125(3), P. 353 - 364

Published: Jan. 2, 2019

Fatigue is a common and distressing symptom in both patients with cancer survivors. There substantial variation the severity persistence of cancer‐related fatigue that may be driven by individual differences host factors, including characteristics predate experience as well responses to its treatment. This review examines biobehavioral risk factors linked mechanisms through which they influence across continuum, focus on neuro‐immune processes. Among psychosocial childhood adversity strong consistent predictor fatigue; other include history depression, catastrophizing, lack physical activity, sleep disturbance, compelling preliminary evidence for loneliness trait anxiety. biologic systems, initial work suggests alterations immune, neuroendocrine, neural processes are associated fatigue. The identification key underlying critical development deployment targeted interventions reduce burden growing population Given multidimensional nature fatigue, multiple systems most effective.

Language: Английский

---

Brain-spleen axis in health and diseases: A review and future perspective

Brain Research Bulletin, Journal Year: 2022, Volume and Issue: 182, P. 130 - 140

Published: Feb. 12, 2022

The spleen, an important tissue for the immune system, acts as a filter blood within system. Accumulating evidence suggests that spleen affects number of brain functions in health and diseases via modulation. Systemic inflammation or chronic social defeat stress (CSDS) can cause splenomegaly rodents. Interestingly, new antidepressant arketamine could normalize depression-like behaviors CSDS-susceptible mice. A recent study strongly supports direct connection pathway between whereby regulate humoral defense by two regions, such corticotropin-related neurons paraventricular nucleus (PVN) central amygdala (CeA). Furthermore, afferent efferent vagus nerve signaling may contribute to communication. In this article, we review findings brain-spleen axis diseases.

Language: Английский

---

Psychoneuroimmunology: An Introduction to Immune-to-Brain Communication and Its Implications for Clinical Psychology

Annual Review of Clinical Psychology, Journal Year: 2023, Volume and Issue: 19(1), P. 331 - 359

Published: Feb. 15, 2023

Research conducted over the past several decades has revolutionized our understanding of role immune system in neural and psychological development function across life span. Our goal this review is to introduce dynamic area research a audience highlight its relevance for clinical psychology. We begin by introducing basic physiology immune-to-brain signaling neuroimmune network, focusing on inflammation. Drawing from preclinical research, we then examine effects activation key domains, including positive negative valence systems, social processes, cognition, arousal (fatigue, sleep), as well links with disorders (depression, posttraumatic stress disorder, anxiety, schizophrenia). also consider psychosocial critical modulator activity focus early adversity. Finally, mind–body interventions that influence may promote resilience.

Language: Английский

---

Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin

Neuronal Signaling, Journal Year: 2023, Volume and Issue: 7(2)

Published: June 26, 2023

Abstract There are several hypotheses concerning the underlying pathophysiological mechanisms of major depression, which centre largely around adaptive changes in neuronal transmission and plasticity, neurogenesis, circuit regional connectivity. The immune endocrine systems commonly implicated driving these changes. An intricate interaction stress hormones, innate cells actions soluble mediators immunity within nervous system is described as being associated with symptoms depression. Bridging processes to neurotransmission signalling key cortical limbic brain circuits critical understanding depression a disorder neuroimmune origins. Emergent areas research include growing recognition system, advances neuroimaging techniques mechanistic insights gained from transgenic animals. Elucidation glial–neuronal interactions providing additional avenues into promising research, development clinically relevant disease models discovery novel therapies. This narrative review focuses on molecular cellular that influenced by inflammation stress. aim this provide an overview our current origin, focusing neuroendocrine dysregulation pathophysiology. Advances lie pursuit biomarkers, potential biomarker signatures improve clinical outcomes yet be fully realised. Further investigations expand panels including integration neuroimaging, utilising individual stratify patients more homogenous subpopulations targeting for new treatment approaches will help address unmet need.

Language: Английский

---