Shedding light on the cell biology of extracellular vesicles

Nature Reviews Molecular Cell Biology, Journal Year: 2018, Volume and Issue: 19(4), P. 213 - 228

Published: Jan. 17, 2018

Language: Английский

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The Tumor Microenvironment Innately Modulates Cancer Progression

Cancer Research, Journal Year: 2019, Volume and Issue: 79(18), P. 4557 - 4566

Published: July 26, 2019

Cancer development and progression occurs in concert with alterations the surrounding stroma. cells can functionally sculpt their microenvironment through secretion of various cytokines, chemokines, other factors. This results a reprogramming cells, enabling them to play determinative role tumor survival progression. Immune are important constituents stroma critically take part this process. Growing evidence suggests that innate immune (macrophages, neutrophils, dendritic lymphoid myeloid-derived suppressor natural killer cells) as well adaptive (T B contribute when present (TME). Cross-talk between cancer proximal ultimately an environment fosters growth metastasis. Understanding nature dialog will allow for improved therapeutics simultaneously target multiple components TME, increasing likelihood favorable patient outcomes.

Language: Английский

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Exosomes

Annual Review of Biochemistry, Journal Year: 2019, Volume and Issue: 88(1), P. 487 - 514

Published: June 20, 2019

Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as cell and enriched selected proteins, lipids, nucleic acids, glycoconjugates. contain an array membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, created by budding at both plasma endosome membranes. Exosome biogenesis is a mechanism quality control, once released, exosomes activities diverse remodeling extracellular matrix transmitting signals molecules other cells. This pathway intercellular vesicle traffic plays important roles many aspects human health disease, including development, immunity, tissue homeostasis, cancer, neurodegenerative diseases. In addition, viruses co-opt exosome pathways for assembling infectious particles establishing host permissiveness. On basis these properties, being developed therapeutic agents multiple disease models.

Language: Английский

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Molecular principles of metastasis: a hallmark of cancer revisited

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: March 12, 2020

Abstract Metastasis is the hallmark of cancer that responsible for greatest number cancer-related deaths. Yet, it remains poorly understood. The continuous evolution biology research and emergence new paradigms in study metastasis have revealed some molecular underpinnings this dissemination process. invading tumor cell, on its way to target site, interacts with other proteins cells. Recognition these interactions improved understanding biological principles metastatic cell govern mobility plasticity. Communication microenvironment allows cells overcome stromal challenges, settle, colonize. These characteristics are driven by genetic epigenetic modifications within itself microenvironment. Establishing mechanisms process crucial finding open therapeutic windows successful interventions. In review, authors explore recent advancements field highlight latest insights contribute shaping cancer.

Language: Английский

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The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 374 - 403

Published: March 1, 2023

Language: Английский

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Concepts of extracellular matrix remodelling in tumour progression and metastasis

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Oct. 9, 2020

Abstract Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions ECM remodelling. Tumours leverage remodelling to create a microenvironment that promotes tumourigenesis metastasis. In this review, we focus on how tumour tumour-associated stromal deposit, biochemically biophysically modify, degrade ECM. These tumour-driven changes support growth, increase migration of cells, remodel in distant organs allow for metastatic progression. A better understanding underlying mechanisms tumourigenic is crucial developing therapeutic treatments patients.

Language: Английский

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New Technologies for Analysis of Extracellular Vesicles

Chemical Reviews, Journal Year: 2018, Volume and Issue: 118(4), P. 1917 - 1950

Published: Jan. 31, 2018

Extracellular vesicles (EVs) are diverse, nanoscale membrane actively released by cells. Similar-sized can be further classified (e.g., exosomes, microvesicles) based on their biogenesis, size, and biophysical properties. Although initially thought to cellular debris, thus under-appreciated, EVs now increasingly recognized as important vehicles of intercellular communication circulating biomarkers for disease diagnoses prognosis. Despite clinical potential, the lack sensitive preparatory analytical technologies poses a barrier translation. New platforms including molecular ones being developed address these challenges. Recent advances in field expected have far-reaching impact both basic translational studies. This article aims present comprehensive critical overview emerging EV detection applications.

Language: Английский

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Extracellular vesicles in cancer — implications for future improvements in cancer care

Nature Reviews Clinical Oncology, Journal Year: 2018, Volume and Issue: 15(10), P. 617 - 638

Published: May 23, 2018

Language: Английский

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Current and future perspectives of liquid biopsies in genomics-driven oncology

Nature Reviews Genetics, Journal Year: 2018, Volume and Issue: 20(2), P. 71 - 88

Published: Nov. 8, 2018

Language: Английский

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Exosome-Mediated Metastasis: Communication from a Distance

Developmental Cell, Journal Year: 2019, Volume and Issue: 49(3), P. 347 - 360

Published: May 1, 2019

Language: Английский

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