The biology , function , and biomedical applications of exosomes

Science, Journal Year: 2020, Volume and Issue: 367(6478)

Published: Feb. 7, 2020

Clinical uses of cellular communication Exosomes are a type extracellular vesicle that contain constituents (protein, DNA, and RNA) the cells secrete them. They taken up by distant cells, where they can affect cell function behavior. Intercellular through exosomes seems to be involved in pathogenesis various disorders, including cancer, neurodegeneration, inflammatory diseases. In Review, Kalluri LeBleu discuss biogenesis disease, highlighting areas more research is needed. also potential clinical applications exosome profiling for diagnostics exosome-mediated delivery therapeutics target disease cells. Science , this issue p. eaau6977

Language: Английский

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Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Nature Cell Biology, Journal Year: 2018, Volume and Issue: 21(1), P. 9 - 17

Published: Dec. 11, 2018

Language: Английский

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Reassessment of Exosome Composition

Cell, Journal Year: 2019, Volume and Issue: 177(2), P. 428 - 445.e18

Published: April 1, 2019

Language: Английский

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Reactive Oxygen Species (ROS)-Based Nanomedicine

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(8), P. 4881 - 4985

Published: April 11, 2019

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. The intrinsic biochemical properties ROS, which underlie the mechanisms necessary for growth, fitness, or aging organisms, have been driving researchers to take full advantage these active chemical contributing medical advances. Thanks remarkable advances nanotechnology, great varieties nanomaterials with unique ROS-regulating explored guide temporospatial dynamic behaviors ROS biological milieu, contributes emergence a new-generation therapeutic methodology, i.e., nanomaterial-guided vivo evolution therapy. interdependent relationship between and their corresponding chemistry, biology, nanotherapy leads us propose concept "ROS science", is believed be emerging scientific discipline that studies mechanisms, effects, nanotherapeutic applications ROS. In this review, state-of-art concerning recent progresses on ROS-based nanotherapies summarized detail, emphasis underlying material chemistry by are generated scavenged improved outcomes. Furthermore, key issues cross-disciplinary fields also discussed, aiming unlock innate powers optimized efficacies. We expect our demonstration evolving field will beneficial further development fundamental researches clinical applications.

Language: Английский

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Regulation of microRNA function in animals

Nature Reviews Molecular Cell Biology, Journal Year: 2018, Volume and Issue: 20(1), P. 21 - 37

Published: Aug. 14, 2018

Language: Английский

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RNA delivery by extracellular vesicles in mammalian cells and its applications

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 21(10), P. 585 - 606

Published: May 26, 2020

Language: Английский

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Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

Cell, Journal Year: 2019, Volume and Issue: 177(2), P. 414 - 427.e13

Published: April 1, 2019

PD-L1 on the surface of tumor cells binds its receptor PD-1 effector T cells, thereby suppressing their activity. Antibody blockade can activate an anti-tumor immune response leading to durable remissions in a subset cancer patients. Here, we describe alternative mechanism activity involving secretion tumor-derived exosomes. Removal exosomal inhibits growth, even models resistant anti-PD-L1 antibodies. Exosomal from suppresses cell activation draining lymph node. Systemically introduced rescues growth tumors unable secrete own. Exposure PD-L1-deficient wild-type injected at distant site, simultaneously or months later. Anti-PD-L1 antibodies work additively, not redundantly, with suppress growth. Together, these findings show that represents unexplored therapeutic target, which could overcome resistance current antibody approaches.

Language: Английский

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Sickle cell disease

Nature Reviews Disease Primers, Journal Year: 2018, Volume and Issue: 4(1)

Published: March 14, 2018

Language: Английский

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Exosome-Mediated Metastasis: Communication from a Distance

Developmental Cell, Journal Year: 2019, Volume and Issue: 49(3), P. 347 - 360

Published: May 1, 2019

Language: Английский

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Extracellular vesicles as drug delivery systems: Why and how?

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 159, P. 332 - 343

Published: Jan. 1, 2020

Over the past decades, a multitude of synthetic drug delivery systems has been developed and introduced to market. However, applications such are limited due inefficiency, cytotoxicity and/or immunogenicity. At same time, field natural carrier grown rapidly. One most prominent examples carriers extracellular vesicles (EVs). EVs cell-derived membranous particles which play important roles in intercellular communication. possess number characteristics that qualify them as promising vehicles for delivery. In order take advantage these attributes, an in-depth understanding why unique how we can exploit their qualities is pivotal. Here, review EV features relevant highlight emerging strategies make use those loading targeted

Language: Английский

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