Theranostics,
Journal Year:
2023,
Volume and Issue:
13(5), P. 1607 - 1631
Published: Jan. 1, 2023
Nasopharyngeal
carcinoma
(NPC)
is
a
particular
entity
of
head
neck
cancer
that
generally
regarded
as
genetic
disease
with
diverse
intertumor
and
intratumor
heterogeneity.
This
perspective
review
mainly
outlines
the
up-to-date
knowledge
ecology
NPC
progression,
presents
number
conceptual
stepping-stones.
At
beginning,
I
explicitly
advocate
nature
(cancer)
not
but
an
ecological
disease:
multidimensional
spatiotemporal
"unity
evolution"
pathological
ecosystem.
The
hallmarks
proposed
to
act
factors
population
fitness.
Subsequently,
cells
are
described
invasive
species
its
metastasis
multidirectional
dispersal.
foundational
principles
include
intraspecific
relationship
(e.g.
communication)
interspecific
competition,
predation,
parasitism
mutualism)
interpreted
understand
progression.
"Mulberry-fish-ponds"
model
can
well
illustrate
dynamic
reciprocity
Tumor-host
interface
transition
zone
cancer,
tumor
buddings
should
be
recognized
islands
separated
from
mainland.
It
noted
tumor-host
has
significantly
molecular
functional
edge
effect
because
curvature
irregularity.
Selection
driving
therapy
including
hyperthermia
for
patients,
future
perspectives
in
such
field
"ecological
pathology",
"multidimensional
tumoriecology"
also
discussed.
advance
"nothing
evolution
or
makes
sense
except
light
other".
tree
constructed
comprehensively
point
out
research
direction.
Taken
together,
establishment
theory
might
provide
novel
framework
paradigm
our
understanding
complex
causal
process
potential
preventive
therapeutic
applications
patients.
Nature reviews. Cancer,
Journal Year:
2020,
Volume and Issue:
20(3), P. 174 - 186
Published: Jan. 24, 2020
Abstract
Cancer-associated
fibroblasts
(CAFs)
are
a
key
component
of
the
tumour
microenvironment
with
diverse
functions,
including
matrix
deposition
and
remodelling,
extensive
reciprocal
signalling
interactions
cancer
cells
crosstalk
infiltrating
leukocytes.
As
such,
they
potential
target
for
optimizing
therapeutic
strategies
against
cancer.
However,
many
challenges
present
in
ongoing
attempts
to
modulate
CAFs
benefit.
These
include
limitations
our
understanding
origin
heterogeneity
CAF
function,
it
being
desirable
retain
some
antitumorigenic
functions.
On
basis
meeting
experts
field
biology,
we
summarize
this
Consensus
Statement
current
knowledge
framework
advancing
critical
cell
type
within
microenvironment.
Genes & Diseases,
Journal Year:
2018,
Volume and Issue:
5(2), P. 77 - 106
Published: May 12, 2018
As
the
most
commonly
occurring
cancer
in
women
worldwide,
breast
poses
a
formidable
public
health
challenge
on
global
scale.
Breast
consists
of
group
biologically
and
molecularly
heterogeneous
diseases
originated
from
breast.
While
risk
factors
associated
with
this
varies
respect
to
other
cancers,
genetic
predisposition,
notably
mutations
Cancer Cell,
Journal Year:
2019,
Volume and Issue:
36(4), P. 418 - 430.e6
Published: Oct. 1, 2019
Cellular
diversity
in
tumors
is
a
key
factor
for
therapeutic
failures
and
lethal
outcomes
of
solid
malignancies.
Here,
we
determined
the
single-cell
transcriptomic
landscape
liver
cancer
biospecimens
from
19
patients.
We
found
varying
degrees
heterogeneity
malignant
cells
within
between
diverse
landscapes
tumor
microenvironment
(TME).
Strikingly,
with
higher
were
associated
patient's
worse
overall
survival.
link
hypoxia-dependent
vascular
endothelial
growth
expression
TME
polarization.
Moreover,
T
heterogeneous
showed
lower
cytolytic
activities.
Consistent
results
using
bulk
genomic
profiles
765
tumors.
Our
offer
insight
into
ecosystem
its
impact
on
patient
prognosis.
European Urology,
Journal Year:
2019,
Volume and Issue:
76(4), P. 469 - 478
Published: July 22, 2019
Prostate-specific
membrane
antigen
(PSMA;
folate
hydrolase)
prostate
cancer
(PC)
expression
has
theranostic
utility.
To
elucidate
PC
PSMA
and
associate
this
with
defective
DNA
damage
repair
(DDR).
Membranous
(mPSMA)
was
scored
immunohistochemically
from
metastatic
castration-resistant
(mCRPC)
matching,
same-patient,
diagnostic
biopsies,
correlated
next-generation
sequencing
(NGS)
clinical
outcome
data.
Expression
of
mPSMA
quantitated
by
modified
H-score.
Patient
tested
NGS.
Gene
activity
scores
were
determined
mCRPC
transcriptomes.
Statistical
correlations
utilised
Wilcoxon
signed
rank
tests,
survival
estimated
Kaplan-Meier
test,
sample
heterogeneity
quantified
Shannon's
diversity
index.
at
diagnosis
associated
higher
Gleason
grade
(p
=
0.04)
worse
overall
0.006).
Overall,
levels
increased
(median
H-score
[interquartile
range]:
castration-sensitive
[CSPC]
17.5
[0.0–60.0]
vs
55.0
[2.8–117.5]).
Surprisingly,
42%
(n
16)
CSPC
27%
tissues
sampled
had
no
detectable
(H-score
<10).
Marked
intratumour
expression,
foci
containing
PSMA,
observed
in
all
expressing
(100%)
37
(84%)
biopsies.
Heterogeneous
intrapatient
between
metastases
also
observed,
the
lowest
liver
metastases.
Tumours
DDR
0.016;
87.5
[25.0–247.5]
20
[0.3–98.8];
difference
medians
60
[5.0–95.0]);
validation
cohort
studies
confirmed
patients
deleterious
aberrations
BRCA2
<
0.001;
median
H-score:
300
[165–300];
195.0
[100.0–270.0])
ATM
0.005;
212.5
[136.3–300];
140.0
[55.0–200])
than
molecularly
unselected
biopsies
(55.0
[2.75–117.5]).
Validation
using
transcriptomes
corroborated
these
findings,
indicating
that
SOX2
high
tumours
have
low
expression.
is
upregulated
some
but
not
PCs,
demonstrating
marked
inter-
heterogeneity.
are
merit
further
evaluation
as
predictive
biomarkers
response
for
PSMA-targeted
therapies
larger,
prospective
cohorts.
Through
analysis
samples,
we
report
presence
prostate-specific
(PSMA)
extremely
variable
both
within
one
patient
different
patients.
This
may
limit
usefulness
scans
therapies.
We
show
first
time
cancers
produce
more
so
respond
better
to
PSMA-targeting
treatments.
JCO Clinical Cancer Informatics,
Journal Year:
2019,
Volume and Issue:
3, P. 1 - 13
Published: Feb. 4, 2019
Cancer
biology
involves
complex,
dynamic
interactions
between
cancer
cells
and
their
tissue
microenvironments.
Single-cell
effects
are
critical
drivers
of
clinical
progression.
Chemical
mechanical
communication
tumor
stromal
can
co-opt
normal
physiologic
processes
to
promote
growth
invasion.
cell
heterogeneity
increases
cancer's
ability
test
strategies
adapt
microenvironmental
stresses.
Hypoxia
treatment
select
for
stem
drive
invasion
resistance.
Cell-based
computational
models
(also
known
as
discrete
models,
agent-based
or
individual-based
models)
simulate
individual
they
interact
in
virtual
tissues,
which
allows
us
explore
how
single-cell
behaviors
lead
the
dynamics
we
observe
work
control
systems.
In
this
review,
introduce
broad
range
techniques
available
cell-based
modeling.
The
approaches
from
highly
detailed
just
a
few
morphologies
millions
simpler
three-dimensional
tissues.
Modeling
directly
translate
biologic
observations
into
simulation
rules.
many
cases,
agents
include
molecular-scale
models.
Most
also
transport
oxygen,
drugs,
factors,
allow
link
development
conditions.
We
illustrate
these
methods
with
examples
drawn
hypoxia,
angiogenesis,
invasion,
cells,
immunosurveillance.
An
ecosystem
interoperable
tools
is
emerging
at
time
when
cloud
computing
resources
make
software
easier
access
supercomputing
large-scale
studies
possible.
As
field
develops,
anticipate
that
high-throughput
will
rapidly
space
possibilities,
prescreen
new
therapeutic
strategies,
even
re-engineer
bring
systems
under
control.
