MicroRNAs: From Mechanism to Organism DOI Creative Commons
Philipp J. Dexheimer, Luisa Cochella

Frontiers in Cell and Developmental Biology, Journal Year: 2020, Volume and Issue: 8

Published: June 3, 2020

MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors of gene expression in diverse biological contexts. The emergence small RNA-mediated silencing preceded the onset multicellularity and was followed by a drastic expansion miRNA repertoire conjunction with evolution complexity plant animal kingdoms. Along this process, miRNAs became an essential feature development, no higher metazoan lineage tolerated loss or their associated protein machinery. In fact, ablation biogenesis machinery effector factors results severe embryogenesis defects every studied. review, we summarize recent mechanistic insight into function, while emphasizing features have enabled multicellular organisms to harness potential broad class repressors. We first discuss how different mechanisms regulation used, not only generate spatio-temporal specificity production within animal, but also achieve necessary levels dynamics expression. then explore mechanism for repression resulted diversity complexes cause molecular effects on targets. Multicellular taken advantage variability outcome miRNA-mediated repression, differential use particular cell types even distinct subcellular compartments. Finally, present overview has evolved diversified, families implications sequence diversification. Overall, focusing selected models through lens evolution, highlight canonical biology variations, providing updated will ultimately help us understand contribution development physiology organisms.

Language: Английский

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases DOI
Rajesha Rupaimoole, Frank J. Slack

Nature Reviews Drug Discovery, Journal Year: 2017, Volume and Issue: 16(3), P. 203 - 222

Published: Feb. 17, 2017

Language: Английский

Citations

4128
Regulation of microRNA function in animals DOI
Luca F. R. Gebert, Ian J. MacRae

Nature Reviews Molecular Cell Biology, Journal Year: 2018, Volume and Issue: 20(1), P. 21 - 37

Published: Aug. 14, 2018

Language: Английский

Citations

1929
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches DOI Open Access

Julia Beermann,

Maria-Teresa Piccoli,

Janika Viereck

et al.

Physiological Reviews, Journal Year: 2016, Volume and Issue: 96(4), P. 1297 - 1325

Published: Aug. 18, 2016

Advances in RNA-sequencing techniques have led to the discovery of thousands non-coding transcripts with unknown function. There are several types linear RNAs such as microRNAs (miRNA) and long (lncRNA), well circular (circRNA) consisting a closed continuous loop. This review guides reader through important aspects RNA biology. includes their biogenesis, mode actions, physiological function, role disease context (such cancer or cardiovascular system). We specifically focus on potential therapeutic targets diagnostic biomarkers.

Language: Английский

Citations

1580
The molecular landscape of head and neck cancer DOI
C. René Leemans, Peter J.F. Snijders, Ruud H. Brakenhoff

et al.

Nature reviews. Cancer, Journal Year: 2018, Volume and Issue: 18(5), P. 269 - 282

Published: March 2, 2018

Language: Английский

Citations

1117
miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis DOI Creative Commons

Carmen Elena Condrat,

Dana Claudia Thompson, Mădălina Gabriela Barbu

et al.

Cells, Journal Year: 2020, Volume and Issue: 9(2), P. 276 - 276

Published: Jan. 23, 2020

MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles regulating mRNA through its degradation and adjusting protein levels. In recent years, extraordinary progress has been made in terms identifying origin exact functions miRNA, focusing on their potential use both research clinical field. This review aims at improving current understanding these molecules applicability medical A thorough analysis literature consulting resources available online databases such as NCBI, PubMed, Medline, ScienceDirect, UpToDate was performed. There is promising evidence that spite lack standardized protocols regarding miRNAs practice, they constitute reliable tool for future use. These meet most required criteria being an ideal biomarker, accessibility, high specificity, sensitivity. Despite present limitations, biomarkers various conditions remain impressive As techniques evolve, we anticipate will become routine approach development personalized patient profiles, thus permitting more specific therapeutic interventions.

Language: Английский

Citations

1057
Non-coding RNAs: Classification, Biology and Functioning DOI

Sonja Hombach,

Markus Kretz

Advances in experimental medicine and biology, Journal Year: 2016, Volume and Issue: unknown, P. 3 - 17

Published: Jan. 1, 2016

Language: Английский

Citations

783
RNA-Binding Proteins in Cancer: Old Players and New Actors DOI
Bruno Pereira, Marc Billaud, Raquel Almeida

et al.

Trends in cancer, Journal Year: 2017, Volume and Issue: 3(7), P. 506 - 528

Published: June 21, 2017

Language: Английский

Citations

668
A network-biology perspective of microRNA function and dysfunction in cancer DOI
Cameron P. Bracken, Hamish S. Scott, Gregory J. Goodall

et al.

Nature Reviews Genetics, Journal Year: 2016, Volume and Issue: 17(12), P. 719 - 732

Published: Oct. 31, 2016

Language: Английский

Citations

639
Ultrasensitive detection of miRNA with an antimonene-based surface plasmon resonance sensor DOI Creative Commons
Tianyu Xue, Weiyuan Liang, Yawen Li

et al.

Nature Communications, Journal Year: 2018, Volume and Issue: 10(1)

Published: Dec. 28, 2018

MicroRNA exhibits differential expression levels in cancer and can affect cellular transformation, carcinogenesis metastasis. Although fluorescence techniques using dye molecule labels have been studied, label-free molecular-level quantification of miRNA is extremely challenging. We developed a surface plasmon resonance sensor based on two-dimensional nanomaterial antimonene for the specific detection clinically relevant biomarkers such as miRNA-21 miRNA-155. First-principles energetic calculations reveal that has substantially stronger interaction with ssDNA than graphene previously used DNA sensing, due to thanking more delocalized 5s/5p orbitals antimonene. The limit reach 10 aM, which 2.3-10,000 times higher those existing sensors. combination not-attempted-before exotic sensing material SPR architecture represents an approach unlocking ultrasensitive provides promising avenue early diagnosis, staging, monitoring cancer.

Language: Английский

Citations

637
The role and mechanisms of action of microRNAs in cancer drug resistance DOI Creative Commons

Wengong Si,

Jiaying Shen, Huilin Zheng

et al.

Clinical Epigenetics, Journal Year: 2019, Volume and Issue: 11(1)

Published: Feb. 11, 2019

MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19–25 nt, which can regulate various target genes and thus involved in the regulation variety biological pathological processes, including formation development cancer. Drug resistance cancer chemotherapy is one main obstacles to curing this malignant disease. Statistical data indicate that over 90% mortality patients related drug resistance. be caused by many mechanisms, such as decreased antitumor uptake, modified targets, altered cell cycle checkpoints, or increased DNA damage repair, among others. In recent years, studies have shown miRNAs tumor cells targeting drug-resistance-related influencing proliferation, cycle, apoptosis. A single miRNA often targets number genes, its regulatory effect tissue-specific. review, we emphasize different cancers probe mechanisms deregulated expression miRNAs. The molecular their underlying signaling pathways also explored comprehensively. holistic understanding functions will help us develop better strategies them efficiently finally pave way toward translation into clinics, developing promising approach therapy.

Language: Английский

Citations

599