Theranostics,
Journal Year:
2020,
Volume and Issue:
10(18), P. 8315 - 8342
Published: Jan. 1, 2020
Sirtuin
3
(SIRT3)
is
one
of
the
most
prominent
deacetylases
that
can
regulate
acetylation
levels
in
mitochondria,
which
are
essential
for
eukaryotic
life
and
inextricably
linked
to
metabolism
multiple
organs.
Hitherto,
SIRT3
has
been
substantiated
be
involved
almost
all
aspects
mitochondrial
homeostasis,
protecting
mitochondria
from
a
variety
damage.
Accumulating
evidence
recently
documented
associated
with
many
types
human
diseases,
including
age-related
cancer,
heart
disease
metabolic
indicating
potential
therapeutic
target.
Here
we
focus
on
summarizing
intricate
mechanisms
recent
notable
advances
field
small-molecule
activators
or
inhibitors
targeting
as
well
their
applications
future
drug
discovery.
Nucleic Acids Research,
Journal Year:
2017,
Volume and Issue:
46(D1), P. D296 - D302
Published: Oct. 25, 2017
MicroRNAs
(miRNAs)
are
small
non-coding
RNAs
of
∼
22
nucleotides
that
involved
in
negative
regulation
mRNA
at
the
post-transcriptional
level.
Previously,
we
developed
miRTarBase
which
provides
information
about
experimentally
validated
miRNA-target
interactions
(MTIs).
Here,
describe
an
updated
database
containing
422
517
curated
MTIs
from
4076
miRNAs
and
23
054
target
genes
collected
over
8500
articles.
The
number
by
strong
evidence
has
increased
∼1.4-fold
since
last
update
2016.
In
this
version,
sites
reporter
assay
available
literature
can
be
downloaded.
site
sequence
extract
new
features
for
analysis
via
a
machine
learning
approach
help
to
evaluate
performance
prediction
tools.
Furthermore,
different
ways
browsing
enhance
user
specific
MTIs.
With
these
improvements,
serves
as
more
comprehensively
annotated,
databases
field
miRNA
related
research.
is
http://miRTarBase.mbc.nctu.edu.tw/.
Journal of Cellular Physiology,
Journal Year:
2018,
Volume and Issue:
234(5), P. 5451 - 5465
Published: Nov. 23, 2018
Abstract
MicroRNAs
(miRNAs)
are
a
class
of
small
noncoding
RNAs,
which
function
in
posttranscriptional
regulation
gene
expression.
They
powerful
regulators
various
cellular
activities
including
cell
growth,
differentiation,
development,
and
apoptosis.
have
been
linked
to
many
diseases,
currently
miRNA‐mediated
clinical
trial
has
shown
promising
results
for
treatment
cancer
viral
infection.
This
review
provides
an
overview
update
on
miRNAs
biogenesis,
expression,
their
biological
functions,
role
epigenetics
cell–cell
communication.
In
addition,
alteration
following
exercise,
association
with
therapeutic
potential
will
be
explained.
Finally,
miRNA
bioinformatics
tools
conventional
methods
detection
quantification
discussed.
Annual Review of Pathology Mechanisms of Disease,
Journal Year:
2018,
Volume and Issue:
13(1), P. 395 - 412
Published: Jan. 24, 2018
Metastasis
is
the
major
cause
of
cancer-related
deaths;
therefore,
prevention
and
treatment
metastasis
are
fundamental
to
improving
clinical
outcomes.
Epithelial
mesenchymal
transition
(EMT),
an
evolutionarily
conserved
developmental
program,
has
been
implicated
in
carcinogenesis
confers
metastatic
properties
upon
cancer
cells
by
enhancing
mobility,
invasion,
resistance
apoptotic
stimuli.
Furthermore,
EMT-derived
tumor
acquire
stem
cell
exhibit
marked
therapeutic
resistance.
Given
these
attributes,
complex
biological
process
EMT
heralded
as
a
key
hallmark
carcinogenesis,
targeting
pathways
constitutes
attractive
strategy
for
treatment.
However,
demonstrating
necessity
vivo
technically
challenging,
recent
efforts
demonstrate
functional
contribution
have
yielded
unexpected
results.
Therefore,
determining
role
remains
area
active
investigation.
Studies
using
improved
lineage
tracing
systems,
dynamic
imaging,
clinically
relevant
models
potential
uncover
direct
link
between
metastasis.
This
review
focuses
primarily
on
advances
emerging
concepts
biology
discusses
future
directions
context
novel
diagnostic
opportunities.
