Association of social isolation and loneliness with risk of incident hospital-treated infections: an analysis of data from the UK Biobank and Finnish Health and Social Support studies DOI Creative Commons
Marko Elovainio, Kaisla Komulainen, Pyry N. Sipilä

et al.

The Lancet Public Health, Journal Year: 2023, Volume and Issue: 8(2), P. e109 - e118

Published: Jan. 18, 2023

Although loneliness and social isolation have been linked to an increased risk of non-communicable diseases such as cardiovascular disease dementia, their association with the severe infection is uncertain. We aimed examine associations between hospital-treated infections using data from two independent cohort studies.We assessed incident for participants UK Biobank study aged 38-73 years at baseline nationwide population-based Finnish Health Social Support (HeSSup) 20-54 baseline. For inclusion in study, had be national health registries, no history or before baseline, complete on isolation. Participants missing infections, loneliness, were excluded both cohorts. The outcome was defined a hospital admission primary diagnosis infection, ascertained via linkage electronic records.After exclusion 8·6 million not responding providing appropriate consent, consisted 456 905 (249 586 women 207 319 men). 26 860 (6·2%) 436 001 available reported being lonely 40 428 (9·0%) 448 114 socially isolated. During median 8·9 (IQR 8·0-9·6) follow-up, 51 361 admitted due infectious disease. After adjustment age, sex, demographic lifestyle factors, morbidities, associated (hazard ratio [HR] 1·12 [95% CI 1·07-1·16]), whereas (HR 1·01 0·97-1·04]). Of 64 797 individuals HeSSup cohort, 18 468 (11 367 7101 men) eligible inclusion. 4466 (24·4%) 296 1776 (9·7%) 376 follow-up 10·0 10·0-10·1), 814 (4·4%) HRs replicated those (multivariable-adjusted HR 1·32 1·06-1·64]; 1·08 [0·87-1·35] isolation).Loneliness might increase susceptibility although magnitude this effect appears modest residual confounding cannot excluded. Interventional studies are required policy recommendations can advance.Academy Finland, Medical Research Council, Wellcome Trust UK.

Language: Английский

2021 ESC Guidelines on cardiovascular disease prevention in clinical practice DOI Open Access
Frank L.J. Visseren,

François Mach,

Yvo M. Smulders

et al.

European Heart Journal, Journal Year: 2021, Volume and Issue: 42(34), P. 3227 - 3337

Published: Aug. 30, 2021

The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge evidence available at time their publication.The is not responsible in event any contradiction, discrepancy and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical judgment, as well determination implementation preventive, diagnostic strategies; however, do override, way whatsoever, individual responsibility make appropriate accurate decisions each patient's condition consultation with that patient and, where necessary, caregiver.Nor exempt from taking full updated competent order manage case light scientifically accepted data pursuant respective ethical professional obligations.It also professional's verify applicable rules regulations relating drugs devices prescription.

Language: Английский

Citations

4328
Chronic inflammation in the etiology of disease across the life span DOI Open Access
David Furman, Judith Campisi, Eric Verdin

et al.

Nature Medicine, Journal Year: 2019, Volume and Issue: 25(12), P. 1822 - 1832

Published: Dec. 1, 2019

Language: Английский

Citations

3423
Handbook of Religion and Health DOI
Harold G. Koenig, Tyler J. VanderWeele, John R. Peteet

et al.

Oxford University Press eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 23, 2023

Abstract The 2001 (first) edition of this Handbook was a comprehensive review history, research, and discussions on religion health through the year 2000. Appendix listed 1,200 separate quantitative studies each rated in quality 0–10 scale, followed by about 2,000 references an extensive index for rapid topic identification. 2012 (second) systematically updated research from 2000 to 2010, with number then reaching thousands. This 2023 (third) is most scientifically rigorous date, covering best published 2021 emphasis prospective randomized controlled trials. Beginning Foreword Dr. Howard K. Koh, former US Assistant Secretary Health Department Human Services, nearly 600,000-word volume examines almost every aspect health, reviewing past more recent relationship between outcomes. Furthermore, all its 34 chapters conclude clinical community applications, making text relevant both healthcare professionals (physicians, nurses, social workers, rehabilitation therapists, counselors, psychologists, sociologists, etc.) clergy (community clergy, chaplains, pastoral etc.). book’s focuses studies, describing study single line, allowing researchers quickly locate existing research. It should not be surprising that two decades has been cited health.

Language: Английский

Citations

1065
Stress and Health: A Review of Psychobiological Processes DOI Open Access
Daryl B. O’Connor, Julian F. Thayer, Kavita Vedhara

et al.

Annual Review of Psychology, Journal Year: 2020, Volume and Issue: 72(1), P. 663 - 688

Published: Sept. 4, 2020

The cumulative science linking stress to negative health outcomes is vast. Stress can affect directly, through autonomic and neuroendocrine responses, but also indirectly, changes in behaviors. In this review, we present a brief overview of (a) why should be interested the context health; (b) response allostatic load; (c) some key biological mechanisms which impacts health, such as by influencing hypothalamic-pituitary-adrenal axis regulation cortisol dynamics, nervous system, gene expression; (d) evidence clinical relevance stress, exemplified risk infectious diseases. studies reviewed article confirm that has an impact on multiple systems. Future work ought consider further importance early-life adversity continue explore how different systems interact processes.

Language: Английский

Citations

629
Neutrophils as regulators of cardiovascular inflammation DOI
Carlos Silvestre-Roig,

Quinte Braster,

Almudena Ortega‐Gómez

et al.

Nature Reviews Cardiology, Journal Year: 2020, Volume and Issue: 17(6), P. 327 - 340

Published: Jan. 29, 2020

Language: Английский

Citations

416
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice DOI Open Access
Frank L.J. Visseren,

François Mach,

Yvo M. Smulders

et al.

European Journal of Preventive Cardiology, Journal Year: 2021, Volume and Issue: 29(1), P. 5 - 115

Published: Sept. 24, 2021

The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge evidence available at time their publication.The is not responsible in event any contradiction, discrepancy and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical judgment, as well determination implementation preventive, diagnostic strategies; however, do override, way whatsoever, individual responsibility make appropriate accurate decisions each patient's condition consultation with that patient and, where necessary, caregiver.Nor exempt from taking full updated competent order manage case light scientifically accepted data pursuant respective ethical professional obligations.It also professional's verify applicable rules regulations relating drugs devices prescription.

Language: Английский

Citations

382
COVID-19 pandemic: the effects of quarantine on cardiovascular risk DOI Creative Commons
Anna Vittoria Mattioli, Matteo Ballerini Puviani, Milena Nasi

et al.

European Journal of Clinical Nutrition, Journal Year: 2020, Volume and Issue: 74(6), P. 852 - 855

Published: May 5, 2020

COVID-19 is causing a global pandemic with high number of deaths and infected people. To contain the diffusion virus, Governments have enforced restrictions on outdoor activities or even collective quarantine population. One important consequence change in lifestyle: reduced physical activity unhealthy diet. 2019 guidelines for primary prevention cardiovascular disease indicate that "Adults should engage at least 150 minute per week accumulated moderate-intensity 75 vigorous-intensity aerobic (or an equivalent combination moderate vigorous activity) to reduce ASCVD risk." During quarantine, strategies further increase home-based follow healthy diet be implemented. Quarantine carries some long-term effects disease, mainly related lifestyle anxiety. Following action supporting mandatory encourage people return good lifestyle.

Language: Английский

Citations

373
Global, regional, and national burdens of ischemic heart disease and stroke attributable to exposure to long working hours for 194 countries, 2000–2016: A systematic analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury DOI Creative Commons
Frank Pega, Bálint Náfrádi, Natalie C. Momen

et al.

Environment International, Journal Year: 2021, Volume and Issue: 154, P. 106595 - 106595

Published: May 16, 2021

World Health Organization (WHO) and International Labour (ILO) systematic reviews reported sufficient evidence for higher risks of ischemic heart disease stroke amongst people working long hours (≥55 hours/week), compared with standard (35-40 hours/week). This article presents WHO/ILO Joint Estimates global, regional, national exposure to hours, 194 countries, the attributable burdens stroke, 183 by sex age, 2000, 2010, 2016.We calculated population-attributable fractions from estimates population exposed relative on diseases reviews. The was modelled using data 2324 cross-sectional surveys 1742 quarterly survey datasets. Attributable were estimated applying WHO's Global total burdens.In 2016, 488 million (95% uncertainty range: 472-503 million), or 8.9% (8.6-9.1) global population, An 745,194 deaths (705,786-784,601) 23.3 disability-adjusted life years (22.2-24.4) combined this exposure. 3.7% (3.4-4.0) 6.9% (6.4-7.5); they 5.3% (4.9-5.6) 9.3% (8.7-9.9) stroke.WHO ILO estimate hours/week) is common causes large stroke. Protecting promoting occupational workers' safety health requires interventions reduce hazardous hours.

Language: Английский

Citations

276
Lifestyle interventions for the prevention and treatment of hypertension DOI
Pedro L. Valenzuela, Pedro Carrera‐Bastos, Beatriz G. Gálvez

et al.

Nature Reviews Cardiology, Journal Year: 2020, Volume and Issue: 18(4), P. 251 - 275

Published: Oct. 9, 2020

Language: Английский

Citations

256
Summary of Updated Recommendations for Primary Prevention of Cardiovascular Disease in Women DOI Creative Commons
Leslie Cho, Melinda B. Davis, Islam Y. Elgendy

et al.

Journal of the American College of Cardiology, Journal Year: 2020, Volume and Issue: 75(20), P. 2602 - 2618

Published: May 1, 2020

Language: Английский

Citations

247