Nature Communications,
Journal Year:
2016,
Volume and Issue:
7(1)
Published: July 22, 2016
Abstract
Nanoparticle-mediated
delivery
of
functional
macromolecules
is
a
promising
method
for
treating
variety
human
diseases.
Among
nanoparticles,
cell-derived
exosomes
have
recently
been
highlighted
as
new
therapeutic
strategy
the
in
vivo
nucleotides
and
chemical
drugs.
Here
we
describe
tool
intracellular
target
proteins,
named
‘exosomes
protein
loading
via
optically
reversible
protein–protein
interactions’
(EXPLORs).
By
integrating
interaction
module
controlled
by
blue
light
with
endogenous
process
exosome
biogenesis,
are
able
to
successfully
load
cargo
proteins
into
newly
generated
exosomes.
Treatment
protein-loaded
EXPLORs
shown
significantly
increase
levels
their
function
recipient
cells
vitro
.
These
results
clearly
indicate
potential
mechanism
efficient
transfer
protein-based
therapeutics
tissues.
Nature Communications,
Journal Year:
2015,
Volume and Issue:
6(1)
Published: June 4, 2015
Abstract
Enhancing
the
robustness
of
functional
biomacromolecules
is
a
critical
challenge
in
biotechnology,
which
if
addressed
would
enhance
their
use
pharmaceuticals,
chemical
processing
and
biostorage.
Here
we
report
novel
method,
inspired
by
natural
biomineralization
processes,
provides
unprecedented
protection
encapsulating
them
within
class
porous
materials
termed
metal-organic
frameworks.
We
show
that
proteins,
enzymes
DNA
rapidly
induce
formation
protective
framework
coatings
under
physiological
conditions
concentrating
building
blocks
facilitating
crystallization
around
biomacromolecules.
The
resulting
biocomposite
stable
normally
decompose
many
biological
macromolecules.
For
example,
urease
horseradish
peroxidase
protected
shell
are
found
to
retain
bioactivity
after
being
treated
at
80
°C
boiled
dimethylformamide
(153
°C),
respectively.
This
rapid,
low-cost
biomimetic
mineralization
process
gives
rise
new
possibilities
for
exploitation
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Feb. 14, 2022
Abstract
Peptide
drug
development
has
made
great
progress
in
the
last
decade
thanks
to
new
production,
modification,
and
analytic
technologies.
Peptides
have
been
produced
modified
using
both
chemical
biological
methods,
together
with
novel
design
delivery
strategies,
which
helped
overcome
inherent
drawbacks
of
peptides
allowed
continued
advancement
this
field.
A
wide
variety
natural
obtained
studied,
covering
multiple
therapeutic
areas.
This
review
summarizes
efforts
achievements
peptide
discovery,
their
current
applications.
We
also
discuss
value
challenges
associated
future
developments
peptides.
ACS Nano,
Journal Year:
2017,
Volume and Issue:
11(3), P. 2313 - 2381
Published: March 14, 2017
The
design
and
use
of
materials
in
the
nanoscale
size
range
for
addressing
medical
health-related
issues
continues
to
receive
increasing
interest.
Research
nanomedicine
spans
a
multitude
areas,
including
drug
delivery,
vaccine
development,
antibacterial,
diagnosis
imaging
tools,
wearable
devices,
implants,
high-throughput
screening
platforms,
etc.
using
biological,
nonbiological,
biomimetic,
or
hybrid
materials.
Many
these
developments
are
starting
be
translated
into
viable
clinical
products.
Here,
we
provide
an
overview
recent
highlight
current
challenges
upcoming
opportunities
field
translation
clinic.
Bioengineering & Translational Medicine,
Journal Year:
2016,
Volume and Issue:
1(1), P. 10 - 29
Published: March 1, 2016
Nanoparticle/microparticle-based
drug
delivery
systems
for
systemic
(i.e.,
intravenous)
applications
have
significant
advantages
over
their
nonformulated
and
free
counterparts.
For
example,
nanoparticle
are
capable
of
delivering
therapeutics
treating
areas
the
body
that
other
cannot
reach.
As
such,
imaging
one
most
investigated
in
preclinical
clinical
settings.
Here,
we
will
highlight
diversity
types,
key
these
counterparts,
discuss
overall
potential
influencing
care.
In
particular,
focus
on
current
trials
formulations
yet
to
be
clinically
approved.
Additional
emphasis
approved
systems,
both
currently
indications
use
active
trials.
Finally,
many
often
overlooked
biological,
technological,
study
design
challenges
impact
success
systems.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(19), P. 5905 - 5905
Published: Sept. 29, 2021
The
drug
delivery
system
enables
the
release
of
active
pharmaceutical
ingredient
to
achieve
a
desired
therapeutic
response.
Conventional
systems
(tablets,
capsules,
syrups,
ointments,
etc.)
suffer
from
poor
bioavailability
and
fluctuations
in
plasma
level
are
unable
sustained
release.
Without
an
efficient
mechanism,
whole
process
can
be
rendered
useless.
Moreover,
has
delivered
at
specified
controlled
rate
target
site
as
precisely
possible
maximum
efficacy
safety.
Controlled
developed
combat
problems
associated
with
conventional
delivery.
There
been
tremendous
evolution
past
two
decades
ranging
macro
scale
nano
intelligent
targeted
initial
part
this
review
provides
basic
understanding
emphasis
on
pharmacokinetics
drug.
It
also
discusses
their
limitations.
Further,
discussed
detail
design
considerations,
classifications
drawings.
In
addition,
nano-drug
delivery,
smart
using
stimuli-responsive
biomaterials
is
recent
key
findings.
paper
concludes
challenges
faced
future
directions
Journal of Medicinal Chemistry,
Journal Year:
2017,
Volume and Issue:
61(4), P. 1382 - 1414
Published: July 24, 2017
Over
the
past
decade,
peptide
drug
discovery
has
experienced
a
revival
of
interest
and
scientific
momentum,
as
pharmaceutical
industry
come
to
appreciate
role
that
therapeutics
can
play
in
addressing
unmet
medical
needs
how
this
class
compounds
be
an
excellent
complement
or
even
preferable
alternative
small
molecule
biological
therapeutics.
In
Perspective,
we
give
concise
description
recent
progress
holistic
manner,
highlighting
enabling
technological
advances
affecting
nearly
every
aspect
field:
from
lead
discovery,
synthesis
optimization,
delivery.
An
emphasis
is
placed
on
describing
research
efforts
overcome
inherent
weaknesses
drugs,
particular
their
poor
pharmacokinetic
properties,
these
have
been
critical
design,
subsequent
development
novel
