The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women DOI Creative Commons
Roberto Romero, Sonia S. Hassan,

Pawel Gajer

et al.

Microbiome, Journal Year: 2014, Volume and Issue: 2(1)

Published: Feb. 3, 2014

This study was undertaken to characterize the vaginal microbiota throughout normal human pregnancy using sequence-based techniques. We compared microbial composition of non-pregnant patients with a group pregnant women who delivered at term. A retrospective case–control longitudinal designed and included (n = 32) term (38 42 weeks) without complications 22). Serial samples fluid were collected from both patients. 16S rRNA gene survey conducted pyrosequencing structure stability microbiota. Linear mixed effects models generalized estimating equations used identify phylotypes whose relative abundance different between two groups. The that (higher Lactobacillus vaginalis, L. crispatus, gasseri jensenii lower 22 other in women). Bacterial community state type (CST) IV-B or CST IV-A characterized by high species genus Atopobium as well presence Prevotella, Sneathia, Gardnerella, Ruminococcaceae, Parvimonas, Mobiluncus taxa previously shown be associated bacterial vaginosis less frequent pregnancy. higher than women; however, during pregnancy, communities shift almost exclusively one dominated spp. another report first Differences observed. predominant members These results can serve basis relationship microbiome adverse outcomes.

Language: Английский

Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences DOI Open Access
Morgan G. I. Langille, Jesse Zaneveld, J. Gregory Caporaso

et al.

Nature Biotechnology, Journal Year: 2013, Volume and Issue: 31(9), P. 814 - 821

Published: Aug. 25, 2013

Language: Английский

Citations

8198

Induced Systemic Resistance by Beneficial Microbes DOI
Corné M. J. Pieterse,

Christos Zamioudis,

Roeland L. Berendsen

et al.

Annual Review of Phytopathology, Journal Year: 2014, Volume and Issue: 52(1), P. 347 - 375

Published: June 6, 2014

Beneficial microbes in the microbiome of plant roots improve health. Induced systemic resistance (ISR) emerged as an important mechanism by which selected growth-promoting bacteria and fungi rhizosphere prime whole body for enhanced defense against a broad range pathogens insect herbivores. A wide variety root-associated mutualists, including Pseudomonas, Bacillus, Trichoderma, mycorrhiza species sensitize immune system without directly activating costly defenses. This review focuses on molecular processes at interface between ISR-eliciting progress our understanding ISR signaling priming. The central role root-specific transcription factor MYB72 onset phytohormones regulatory proteins expression aboveground parts are highlighted. Finally, ecological function ISR-inducing root is discussed.

Language: Английский

Citations

2562

Plastic and Human Health: A Micro Issue? DOI
Stephanie Wright, Frank J. Kelly

Environmental Science & Technology, Journal Year: 2017, Volume and Issue: 51(12), P. 6634 - 6647

Published: May 22, 2017

Microplastics are a pollutant of environmental concern. Their presence in food destined for human consumption and air samples has been reported. Thus, microplastic exposure via diet or inhalation could occur, the health effects which unknown. The current review article draws upon cross-disciplinary scientific literature to discuss evaluate potential impacts microplastics outlines urgent areas future research. Key up September 2016 relating accumulation, particle toxicity, chemical microbial contaminants was critically examined. Although is an emerging field, complementary existing fields indicate particle, hazards. If inhaled ingested, may accumulate exert localized toxicity by inducing enhancing immune response. Chemical occur due leaching component monomers, endogenous additives, adsorbed pollutants. Chronic anticipated be greater concern accumulative effect that occur. This expected dose-dependent, robust evidence-base levels currently lacking. there impact health, assessing burdens key. information will guide research into mechanisms hence therein possible effects.

Language: Английский

Citations

2510

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication DOI Creative Commons
Ygor Parladore Silva, Andressa Bernardi, Rudimar Luiz Frozza

et al.

Frontiers in Endocrinology, Journal Year: 2020, Volume and Issue: 11

Published: Jan. 31, 2020

A substantial body of evidence supports that the gut microbiota plays a pivotal role in regulation metabolic, endocrine and immune functions. In recent years, there has been growing recognition involvement modulation multiple neurochemical pathways through highly interconnected gut-brain axis. Although amazing scientific breakthroughs over last few years have expanded our knowledge on communication between microbes their hosts, underpinnings microbiota-gut-brain crosstalk remain to be determined. Short-chain fatty acids (SCFAs), main metabolites produced colon by bacterial fermentation dietary fibers resistant starch, are speculated play key neuro-immunoendocrine regulation. However, underlying mechanisms which SCFAs might influence brain physiology behavior not fully elucidated. this review, we will outline current about interactions. We also highlight how development future treatments for central nervous system (CNS) disorders can take advantage intimate mutual interactions with exploring function.

Language: Английский

Citations

1949

The role of the gut microbiota in nutrition and health DOI
Harry J. Flint, Karen P. Scott, Petra Louis

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2012, Volume and Issue: 9(10), P. 577 - 589

Published: Sept. 4, 2012

Language: Английский

Citations

1891

Alterations of the human gut microbiome in liver cirrhosis DOI
Nan Qin,

Fengling Yang,

Ang Li

et al.

Nature, Journal Year: 2014, Volume and Issue: 513(7516), P. 59 - 64

Published: July 23, 2014

Language: Английский

Citations

1886

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota DOI
Sofia K. Forslund, Falk Hildebrand, Trine Nielsen

et al.

Nature, Journal Year: 2015, Volume and Issue: 528(7581), P. 262 - 266

Published: Dec. 1, 2015

Language: Английский

Citations

1867

Antibiotics in early life alter the murine colonic microbiome and adiposity DOI
Ilseung Cho, Shingo Yamanishi, Laura M. Cox

et al.

Nature, Journal Year: 2012, Volume and Issue: 488(7413), P. 621 - 626

Published: Aug. 1, 2012

Language: Английский

Citations

1523

You are what you eat: diet, health and the gut microbiota DOI
Niv Zmora, Jotham Suez, Eran Elinav

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2018, Volume and Issue: 16(1), P. 35 - 56

Published: Sept. 27, 2018

Language: Английский

Citations

1334

Emerging applications of metabolomics in drug discovery and precision medicine DOI
David S. Wishart

Nature Reviews Drug Discovery, Journal Year: 2016, Volume and Issue: 15(7), P. 473 - 484

Published: March 11, 2016

Language: Английский

Citations

1254