Understanding the tumor immune microenvironment (TIME) for effective therapy

Nature Medicine, Journal Year: 2018, Volume and Issue: 24(5), P. 541 - 550

Published: April 20, 2018

Language: Английский

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Emerging Biological Principles of Metastasis

Cell, Journal Year: 2017, Volume and Issue: 168(4), P. 670 - 691

Published: Feb. 1, 2017

Language: Английский

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Macrophages as regulators of tumour immunity and immunotherapy

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 19(6), P. 369 - 382

Published: Feb. 4, 2019

Language: Английский

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Roles of the immune system in cancer: from tumor initiation to metastatic progression

Genes & Development, Journal Year: 2018, Volume and Issue: 32(19-20), P. 1267 - 1284

Published: Oct. 1, 2018

The presence of inflammatory immune cells in human tumors raises a fundamental question oncology: How do cancer avoid the destruction by attack? In principle, tumor development can be controlled cytotoxic innate and adaptive cells; however, as develops from neoplastic tissue to clinically detectable tumors, evolve different mechanisms that mimic peripheral tolerance order tumoricidal attack. Here, we provide an update recent accomplishments, unifying concepts, future challenges study tumor-associated cells, with emphasis on metastatic carcinomas.

Language: Английский

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Targeting macrophages: therapeutic approaches in cancer

Nature Reviews Drug Discovery, Journal Year: 2018, Volume and Issue: 17(12), P. 887 - 904

Published: Oct. 26, 2018

Language: Английский

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The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

Cell stem cell, Journal Year: 2015, Volume and Issue: 16(3), P. 225 - 238

Published: March 1, 2015

Language: Английский

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Characteristics and Significance of the Pre-metastatic Niche

Cancer Cell, Journal Year: 2016, Volume and Issue: 30(5), P. 668 - 681

Published: Nov. 1, 2016

Language: Английский

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An Immune Atlas of Clear Cell Renal Cell Carcinoma

Cell, Journal Year: 2017, Volume and Issue: 169(4), P. 736 - 749.e18

Published: May 1, 2017

Language: Английский

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Liver immunology and its role in inflammation and homeostasis

Cellular and Molecular Immunology, Journal Year: 2016, Volume and Issue: 13(3), P. 267 - 276

Published: April 11, 2016

The human liver is usually perceived as a non-immunological organ engaged primarily in metabolic, nutrient storage and detoxification activities. However, we now know that the healthy also site of complex immunological activity mediated by diverse immune cell repertoire well non-hematopoietic populations. In non-diseased liver, metabolic tissue remodeling functions require elements inflammation. This inflammation, combination with regular exposure to dietary microbial products, creates potential for excessive activation. this microenvironment, hepatic system tolerates harmless molecules while at same time remaining alert possible infectious agents, malignant cells or damage. Upon appropriate activation challenge pathogens damage, mechanisms resolve inflammation are essential maintain homeostasis. Failure clear 'dangerous' stimuli regulate appropriately activated leads pathological disrupted homeostasis characterized progressive development fibrosis, cirrhosis eventual failure. Hepatic inflammatory therefore have spectrum roles adult liver; they and, when dysregulated, key drivers pathology associated chronic infection, autoimmunity malignancy. review, explore changing perception mediators normal propose targeting liver-specific regulation pathways therapeutic approach treat disease.

Language: Английский

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Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

Chemical Society Reviews, Journal Year: 2017, Volume and Issue: 46(12), P. 3830 - 3852

Published: Jan. 1, 2017

Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared with normal tissue, the microenvironment has some unique properties, such as vascular abnormalities, hypoxia acidic pH. There are many types of cells, including macrophages, immune fibroblast fed by defective blood vessels in solid tumour. Exploiting benefit design nanoparticles for enhanced therapeutic effectiveness. In this review article, we summarized recent progress various nanoformulations cancer therapy, a special emphasis on stimuli-responsive ones. Numerous modulation strategies promising efficacy have also been highlighted. Future challenges opportunities consideration discussed detail. We believe that these offer good chance practical translation nanoparticle formulas into clinic.

Language: Английский

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