Integrins and Integrin-Associated Proteins in the Cardiac Myocyte DOI Open Access

Sharon Israeli‐Rosenberg,

Ana Maria Manso, Hideshi Okada

et al.

Circulation Research, Journal Year: 2014, Volume and Issue: 114(3), P. 572 - 586

Published: Jan. 30, 2014

Integrins are heterodimeric, transmembrane receptors that expressed in all cells, including those the heart. They participate multiple critical cellular processes adhesion, extracellular matrix organization, signaling, survival, and proliferation. Particularly relevant for a contracting muscle cell, integrins mechanotransducers, translating mechanical to biochemical information. Although it is likely cardiovascular clinicians scientists have highest recognition of system from drugs used inhibit platelet aggregation, focus this article will be on role specifically cardiac myocyte. After general introduction integrin biology, discuss important work mechanotransduction, lessons learned about function range model organisms. Then we detail integrin-related proteins myocyte, how may interact with ion channels mediate viral uptake into also play stem cell biology. Finally, directions future study.

Language: Английский

Remodelling the extracellular matrix in development and disease DOI

Caroline Bonnans,

Jonathan Chou, Zena Werb

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2014, Volume and Issue: 15(12), P. 786 - 801

Published: Nov. 21, 2014

Language: Английский

Citations

3697
Extracellular matrix: A dynamic microenvironment for stem cell niche DOI Creative Commons
Francesca Gattazzo, Anna Urciuolo, Paolo Bonaldo

et al.

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2014, Volume and Issue: 1840(8), P. 2506 - 2519

Published: Jan. 11, 2014

Extracellular matrix (ECM) is a dynamic and complex environment characterized by biophysical, mechanical biochemical properties specific for each tissue able to regulate cell behavior. Stem cells have key role in the maintenance regeneration of tissues they are located microenvironment, defined as niche.We overview progresses that been made elucidating stem niches discuss mechanisms which ECM affects We also summarize current tools experimental models studying ECM-stem interactions.ECM represents an essential player niche, since it can directly or indirectly modulate maintenance, proliferation, self-renewal differentiation cells. Several molecules play regulatory functions different types cells, based on its molecular composition be deposited finely tuned providing most appropriate niche various tissues. Engineered biomaterials mimic vivo characteristics provide suitable vitro dissecting roles exerted components behavior.ECM component involved aspects behavior, thus having major impact homeostasis under physiological pathological conditions. This article part Special Issue entitled Matrix-mediated behaviour properties.

Language: Английский

Citations

1190
The extracellular matrix: Tools and insights for the “omics” era DOI Creative Commons
Alexandra Naba, Karl R. Clauser,

Huiming Ding

et al.

Matrix Biology, Journal Year: 2015, Volume and Issue: 49, P. 10 - 24

Published: July 8, 2015

The extracellular matrix (ECM) is a fundamental component of multicellular organisms that provides mechanical and chemical cues orchestrate cellular tissue organization functions. Degradation, hyperproduction or alteration the composition ECM cause accompany numerous pathologies. Thus, better characterization composition, metabolism, biology can lead to identification novel prognostic diagnostic markers therapeutic opportunities. development over last few years high-throughput (“omics”) approaches has considerably accelerated pace discovery in life sciences. In this review, we describe new bioinformatic tools experimental strategies for research, illustrate how these be exploited provide insights our understanding biology. We also introduce web platform “the matrisome project” database MatrisomeDB compiles silico vivo data on matrisome, defined as ensemble genes encoding ECM-associated proteins. Finally, present first draft an atlas built by compiling proteomics 14 different tissues tumor types.

Language: Английский

Citations

909
Silk fibroin as biomaterial for bone tissue engineering DOI
J. Melke,

Swati Midha,

Sourabh Ghosh

et al.

Acta Biomaterialia, Journal Year: 2015, Volume and Issue: 31, P. 1 - 16

Published: Sept. 7, 2015

Language: Английский

Citations

712
Advances in crosslinking strategies of biomedical hydrogels DOI
Weikang Hu, Zijian Wang, Yu Xiao

et al.

Biomaterials Science, Journal Year: 2018, Volume and Issue: 7(3), P. 843 - 855

Published: Dec. 26, 2018

This review presents the commonly used crosslinking methods for hydrogel synthesis and summarizes current status discusses future perspectives.

Language: Английский

Citations

698
3D printing of hydrogels: Rational design strategies and emerging biomedical applications DOI Creative Commons
Jinhua Li, Chengtie Wu, Paul K. Chu

et al.

Materials Science and Engineering R Reports, Journal Year: 2020, Volume and Issue: 140, P. 100543 - 100543

Published: Feb. 18, 2020

3D printing alias additive manufacturing can transform virtual models created by computer-aided design (CAD) into physical objects in a layer-by-layer manner dispensing with conventional molding or machining. Since the incipiency, significant advancements have been achieved understanding process of and relationship component, structure, property application objects. Because hydrogels are one most feasible classes ink materials for this field has rapidly advancing, Review focuses on hydrogel designs development advanced hydrogel-based biomaterial inks bioinks printing. It covers techniques including laser (stereolithography, two-photon polymerization), extrusion (3D plotting, direct writing), inkjet printing, bioprinting, 4D bioprinting. provides comprehensive overview discussion tailorability material, mechanical, physical, chemical biological properties to enable The range hydrogel-forming polymers covered encompasses biopolymers, synthetic polymers, polymer blends, nanocomposites, functional cell-laden systems. representative biomedical applications selected demonstrate how is being exploited tissue engineering, regenerative medicine, cancer research, vitro disease modeling, high-throughput drug screening, surgical preparation, soft robotics flexible wearable electronics. Incomparable thermoplastics, thermosets, ceramics metals, playing pivotal role creation (bio)systems customizable way. An outlook future directions presented.

Language: Английский

Citations

691
Design, Synthesis, and Characterization of Graphene–Nanoparticle Hybrid Materials for Bioapplications DOI
Perry T. Yin, Shreyas Shah, Manish Chhowalla

et al.

Chemical Reviews, Journal Year: 2015, Volume and Issue: 115(7), P. 2483 - 2531

Published: Feb. 18, 2015

ADVERTISEMENT RETURN TO ISSUEReviewNEXTDesign, Synthesis, and Characterization of Graphene–Nanoparticle Hybrid Materials for BioapplicationsPerry T. Yin†, Shreyas Shah‡, Manish Chhowalla§, Ki-Bum Lee*†‡∥View Author Information† ‡ ∥ †Department Biomedical Engineering, ‡Department Chemistry Chemical Biology, §Department Science ∥Institute Advanced Materials, Devices, Nanotechnology (IAMDN), Rutgers, The State University New Jersey, Piscataway, Jersey 08854, United States*E-mail: [email protected]Cite this: Chem. Rev. 2015, 115, 7, 2483–2531Publication Date (Web):February 18, 2015Publication History Received22 September 2014Published online18 February 2015Published inissue 8 April 2015https://pubs.acs.org/doi/10.1021/cr500537thttps://doi.org/10.1021/cr500537treview-articleACS PublicationsCopyright © 2015 American SocietyRequest reuse permissionsArticle Views21362Altmetric-Citations595LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Composites,Metal nanoparticles,Nanoparticles,Sensors,Two dimensional materials Get e-Alerts

Language: Английский

Citations

689
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment DOI
Guoyou Huang, Fei Li, Xin Zhao

et al.

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(20), P. 12764 - 12850

Published: Oct. 9, 2017

The cell microenvironment has emerged as a key determinant of behavior and function in development, physiology, pathophysiology. extracellular matrix (ECM) within the serves not only structural foundation for cells but also source three-dimensional (3D) biochemical biophysical cues that trigger regulate behaviors. Increasing evidence suggests 3D character is required development many critical responses observed vivo, fueling surge functional biomimetic materials engineering microenvironment. Progress design such improved control behaviors advanced fields tissue regeneration, vitro models, large-scale differentiation, immunotherapy, gene therapy. However, field still its infancy, discoveries about nature cell–microenvironment interactions continue to overturn much early progress field. Key challenges be dissecting roles chemistry, structure, mechanics, electrophysiology microenvironment, understanding harnessing periodicity drift these factors. This review encapsulates where recent advances appear leave ever-shifting state art, it highlights areas which substantial potential uncertainty remain.

Language: Английский

Citations

687
The design of reversible hydrogels to capture extracellular matrix dynamics DOI
Adrianne M. Rosales, Kristi S. Anseth

Nature Reviews Materials, Journal Year: 2016, Volume and Issue: 1(2)

Published: Feb. 2, 2016

Language: Английский

Citations

654
Modulating the stem cell niche for tissue regeneration DOI
Steven Lane, David A. Williams, Fiona M. Watt

et al.

Nature Biotechnology, Journal Year: 2014, Volume and Issue: 32(8), P. 795 - 803

Published: Aug. 1, 2014

Language: Английский

Citations

557