Circulation Research,
Journal Year:
2014,
Volume and Issue:
114(3), P. 572 - 586
Published: Jan. 30, 2014
Integrins
are
heterodimeric,
transmembrane
receptors
that
expressed
in
all
cells,
including
those
the
heart.
They
participate
multiple
critical
cellular
processes
adhesion,
extracellular
matrix
organization,
signaling,
survival,
and
proliferation.
Particularly
relevant
for
a
contracting
muscle
cell,
integrins
mechanotransducers,
translating
mechanical
to
biochemical
information.
Although
it
is
likely
cardiovascular
clinicians
scientists
have
highest
recognition
of
system
from
drugs
used
inhibit
platelet
aggregation,
focus
this
article
will
be
on
role
specifically
cardiac
myocyte.
After
general
introduction
integrin
biology,
discuss
important
work
mechanotransduction,
lessons
learned
about
function
range
model
organisms.
Then
we
detail
integrin-related
proteins
myocyte,
how
may
interact
with
ion
channels
mediate
viral
uptake
into
also
play
stem
cell
biology.
Finally,
directions
future
study.
Proceedings of the National Academy of Sciences,
Journal Year:
2014,
Volume and Issue:
111(45), P. 16148 - 16153
Published: Oct. 27, 2014
Neural
stem
cells
are
multipotent
with
the
ability
to
differentiate
into
neurons,
astrocytes,
and
oligodendrocytes.
Lineage
specification
is
strongly
sensitive
mechanical
properties
of
cellular
environment.
However,
molecular
pathways
transducing
matrix
cues
intracellular
signaling
linked
lineage
remain
unclear.
We
found
that
mechanically
gated
ion
channel
Piezo1
expressed
by
brain-derived
human
neural
stem/progenitor
responsible
for
a
induced
ionic
current.
activity
triggered
traction
forces
elicited
influx
Ca(2+),
known
modulator
differentiation,
in
substrate-stiffness-dependent
manner.
Inhibition
pharmacological
inhibitor
GsMTx-4
or
siRNA-mediated
knockdown
suppressed
neurogenesis
enhanced
astrogenesis.
also
reduced
nuclear
localization
mechanoreactive
transcriptional
coactivator
Yes-associated
protein.
propose
an
important
determinant
mechanosensitive
choice
may
play
similar
roles
other
cells.
Chemical Reviews,
Journal Year:
2017,
Volume and Issue:
117(3), P. 1826 - 1914
Published: Jan. 11, 2017
Functional
graphene
nanomaterials
(FGNs)
are
fast
emerging
materials
with
extremely
unique
physical
and
chemical
properties
physiological
ability
to
interfere
and/or
interact
bioorganisms;
as
a
result,
FGNs
present
manifold
possibilities
for
diverse
biological
applications.
Beyond
their
use
in
drug/gene
delivery,
phototherapy,
bioimaging,
recent
studies
have
revealed
that
can
significantly
promote
interfacial
biointeractions,
particular,
proteins,
mammalian
cells/stem
cells,
microbials.
adsorb
concentrate
nutrition
factors
including
proteins
from
media.
This
accelerates
the
formation
of
extracellular
matrix,
which
eventually
promotes
cell
colonization
by
providing
more
beneficial
microenvironment
adhesion
growth.
Furthermore,
also
cocultured
cells
or
stimulation,
mediate
cellular
signaling
performance.
In
this
review,
we
elucidate
FGNs–bioorganism
interactions
summarize
advancements
on
designing
FGN-based
two-dimensional
three-dimensional
architectures
multifunctional
platforms.
We
discussed
representative
applications
regarding
these
bioactive
architectures.
future
perspectives
challenges
will
be
highlighted.
Due
lack
comprehensive
reviews
field,
review
may
catch
great
interest
inspire
many
new
opportunities
across
broad
range
disciplines.
Stem Cells International,
Journal Year:
2016,
Volume and Issue:
2016, P. 1 - 16
Published: Jan. 1, 2016
Cells
with
stem-like
properties,
tumorigenic
potential,
and
treatment-resistant
phenotypes
have
been
identified
in
many
human
malignancies.
Based
on
the
properties
they
share
nonneoplastic
stem
cells
or
their
ability
to
initiate
propagate
tumors
vivo
,
such
were
designated
as
cancer
(stem-like)
tumor
initiating/propagating
cells.
Owing
implication
treatment
resistance,
(CSCs)
subject
of
intense
investigation
past
years.
Comprehension
CSCs’
intrinsic
mechanisms
develop
survive
even
enhance
aggressive
phenotype
within
hostile
conditions
microenvironment
has
reoriented
therapeutic
strategies
fight
cancer.
This
report
provides
selected
examples
malignancies
which
presence
CSCs
evidenced
briefly
discusses
methods
identify,
isolate,
functionally
characterize
CSC
subpopulation
Relevant
biological
targets
CSCs,
link
proposed
targeting
strategies,
limitations
these
approaches
are
presented.
Two
major
aspects
physiopathology,
namely,
relative
quiescence
plasticity
response
microenvironmental
cues
treatment,
highlighted.
Implications
findings
context
development
new
therapies
discussed.
Stem Cells International,
Journal Year:
2017,
Volume and Issue:
2017, P. 1 - 17
Published: Jan. 1, 2017
Stemness
combines
the
ability
of
a
cell
to
perpetuate
its
lineage,
give
rise
differentiated
cells,
and
interact
with
environment
maintain
balance
between
quiescence,
proliferation,
regeneration.
While
adult
Stem
Cells
display
these
properties
when
participating
in
tissue
homeostasis,
Cancer
(CSCs)
behave
as
their
malignant
equivalents.
CSCs
stemness
various
circumstances,
including
sustaining
cancer
progression,
interaction
search
for
key
survival
factors.
As
result,
can
recurrently
persist
after
therapy.
In
order
understand
how
concept
applies
cancer,
this
review
will
explore
shared
normal
Cells.
First,
we
provide
an
overview
We
thereafter
elaborate
on
features
operate
CSCs.
then
organization
microenvironment
components,
which
enables
hosting.
subsequently
discuss
Mesenchymal
Stem/Stromal
(MSCs),
which,
although
are
limited,
represent
essential
components
Cell
niche
tumor
microenvironment.
next
insights
therapeutic
strategies
targeting
tumors
use
state-of-the-art
techniques
future
research.
Increasing
our
knowledge
is
identifying
new
solutions.
Nano Letters,
Journal Year:
2015,
Volume and Issue:
15(7), P. 4720 - 4729
Published: June 1, 2015
One
of
the
breakthroughs
in
biomaterials
and
regenerative
medicine
latest
decade
is
finding
that
matrix
stiffness
affords
a
crucial
physical
cue
stem
cell
differentiation.
This
statement
was
recently
challenged
by
another
understanding
protein
tethering
on
material
surfaces
instead
essential
to
regulate
cells.
Herein,
we
employed
nonfouling
poly(ethylene
glycol)
(PEG)
hydrogels
as
prevent
nonspecific
adsorption,
meanwhile
covalently
bound
cell-adhesive
arginine-glycine-aspartate
(RGD)
peptides
onto
hydrogel
form
well-defined
nanoarrays
control
specific
adhesion.
approach
enables
decoupling
effects
surface
chemistry.
Mesenchymal
cells
(MSCs)
were
cultured
four
substrates
(two
compressive
moduli
PEG
multiplied
two
RGD
nanospacings)
incubated
mixed
osteogenic
adipogenic
medium.
The
results
illustrate
unambiguously
potent
regulator
Moreover,
reveal
nanospacing
affects
spreading
area
differentiation
rat
MSCs,
regardless
stiffness.
Therefore,
both
nanoscale
spatial
organization
ligands
direct
fate.
Advanced Functional Materials,
Journal Year:
2020,
Volume and Issue:
30(42)
Published: Aug. 18, 2020
Abstract
Hydrogels
are
one
of
the
most
commonly
explored
classes
biomaterials.
Their
chemical
and
structural
versatility
has
enabled
their
use
across
a
wide
range
applications,
including
tissue
engineering,
drug
delivery,
cell
culture.
form
upon
sol–gel
transition,
which
can
be
elicited
by
different
triggers
designed
to
enable
precise
control
over
hydrogelation
kinetics
hydrogel
structure.
The
chosen
trigger
chemistry
have
profound
effect
on
success
targeted
application.
In
this
Progress
Report,
critical
overview
recent
advances
in
design
is
presented,
with
focus
available
strategies
used
formation
networks
(e.g.,
temperature,
light,
ultrasound).
These
presented
within
new
classification
system,
suitability
for
six
key
hydrogel‐based
applications
assessed.
This
Report
intended
guide
selection
inspire
rational
mechanisms.
