Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 152, P. 110714 - 110714
Published: April 14, 2023
Language: Английский
Advanced Materials, Journal Year: 2021, Volume and Issue: 33(30)
Published: June 18, 2021
Abstract Advances in revolutionary technologies pose new challenges for human life; response to them, global responsibility is pushing modern toward greener pathways. Molecular imprinting technology (MIT) a multidisciplinary mimic simulating the specific binding principle of enzymes substrates or antigens antibodies; along with its rapid progress and wide applications, MIT faces challenge complying green sustainable development requirements. With identification environmental risks associated unsustainable MIT, aspect termed has emerged developed. However, so far, no clear definition been provided appraise MIT. Herein, implementation process chemistry demonstrated mnemonic device form an acronym, GREENIFICATION, proposed present principles. The entire greenificated surveyed, including element choice, polymerization implementation, energy input, strategies, waste treatment, recovery, as well impacts these processes on operator health environment. Moreover, assistance upgraded instrumentation deploying goals considered. Finally, future perspectives are presented provide more complete picture road map pave way further development.
Language: Английский
Citations
580
Chemical Reviews, Journal Year: 2020, Volume and Issue: 120(17), P. 9554 - 9582
Published: July 31, 2020
Molecularly imprinted polymers (MIPs) are tailor-made chemical receptors that recognize and bind target molecules with a high affinity selectivity. MIPs came into the spotlight in 1993 when they were dubbed "antibody mimics," ever since, have been widely studied for extraction or trapping of pollutants, immunoassays, design sensors. Owing to novel synthesis strategies resulting more biocompatible form soluble nanogels, these synthetic antibodies found favor biomedical domain since 2010, first time, shown capture eliminate toxin live mice. This review, covering years 2015-2020, will describe rationale behind antibody mimics, different methods employed preparation destined vitro vivo targeting bioimaging cancer biomarkers, an emerging fast-growing area MIP applications. synthesized visualizing glycans protein-based cell overexpressed certain diseases, which well-known biomarkers example tumors. When loaded drugs, could locally kill tumor cells, making them efficient therapeutic agents. We end review by reporting how themselves can act as therapeutics inhibiting growth. These works mark new opening use therapy even immunotherapy, materials future nanomedicine.
Language: Английский
Citations
407
Journal of Clinical Investigation, Journal Year: 2022, Volume and Issue: 132(15)
Published: July 31, 2022
Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in response to cellular damage and stress. Senescent cells (SnCs) can develop characteristic pathogenic senescence-associated secretory phenotype (SASP) that drives secondary disrupts tissue homeostasis, resulting loss repair regeneration. The use transgenic mouse models which SnCs be genetically ablated has established key role for driving age-related disease. Importantly, senotherapeutics have been developed pharmacologically eliminate SnCs, termed senolytics, or suppress SASP other markers senescence, senomorphics. Based on extensive preclinical studies as well small clinical trials demonstrating benefits senotherapeutics, multiple are under way. This Review discusses diseases, strategies target approaches discover advances senolytics.
Language: Английский
Citations
321
TrAC Trends in Analytical Chemistry, Journal Year: 2020, Volume and Issue: 127, P. 115883 - 115883
Published: March 29, 2020
Language: Английский
Citations
194
Sensors, Journal Year: 2020, Volume and Issue: 20(4), P. 996 - 996
Published: Feb. 13, 2020
Owing to their merits of simple, fast, sensitive, and low cost, electrochemical biosensors have been widely used for the diagnosis infectious diseases. As a critical element, receptor determines selectivity, stability, accuracy biosensors. Molecularly imprinted polymers (MIPs) surface (SIPs) great potential be robust artificial receptors. Therefore, extensive studies reported develop MIPs/SIPs detection diseases with high selectivity reliability. In this review, we discuss mechanisms recognition events between different biomarkers, such as signaling molecules, microbial toxins, viruses, bacterial fungal cells. Then, various preparation methods are summarized. Especially, electropolymerization micro-contact imprinting emphasized. Furthermore, applications based disease highlighted. At last, challenges perspectives discussed.
Language: Английский
Citations
185
Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(8), P. 3858 - 3869
Published: Aug. 13, 2020
Molecularly imprinted polymers (MIPs) are chemically synthesized affinity materials with tailor-made binding cavities complementary to the template molecules in shape, size, and functionality. Recently, engineering MIP-based nanomedicines improve cancer therapy has become a rapidly growing field future research direction. Because of unique properties functions MIPs, nanoparticles (nanoMIPs) not only alternatives current nanomaterials for therapy, but also hold potential fill gaps associated biological ligand-based nanomedicines, such as immunogenicity, stability, applicability, economic viability. Here, we survey recent advances design fabrication nanoMIPs highlight their distinct features. In addition, how use these features achieve desired performance, including extended circulation, active targeting, controlled drug release anti-tumor efficacy, is discussed summarized. We expect that this minireview will inspire more advanced studies therapy.
Language: Английский
Citations
168
Biosensors and Bioelectronics, Journal Year: 2020, Volume and Issue: 168, P. 112565 - 112565
Published: Aug. 26, 2020
Language: Английский
Citations
165
Silicon, Journal Year: 2022, Volume and Issue: 14(14), P. 8295 - 8310
Published: Jan. 5, 2022
Language: Английский
Citations
84
ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(44), P. 49399 - 49424
Published: Oct. 31, 2022
The use of porous materials as the core for synthesizing molecularly imprinted polymers (MIPs) adds significant value to resulting sensing system. This review covers in detail current progress and achievements regarding synergistic combination MIPs materials, namely metal/covalent–organic frameworks (MOFs/COFs), including application such development upgraded sensor platforms. different processes involved synthesis MOF/COF-MIPs are outlined, along with their intrinsic properties. Special attention is paid debriefing impact morphological changes that occur through compared those due individual entities. Thereafter, strategies used building sensors, well transduction modes, overviewed discussed. followed by a full description research advances various types MOF/COF-MIP-based (bio)sensors applications fields environmental monitoring, food safety, pharmaceutical analysis. Finally, challenges/drawbacks, prospects this field, discussed detail.
Language: Английский
Citations
76
Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)
Published: Feb. 9, 2023
Cancer is a disease caused by abnormal cell growth that spreads through other parts of the body and threatens life destroying healthy tissues. Therefore, numerous techniques have been employed not only to diagnose monitor progress cancer in precise manner but also develop appropriate therapeutic agents with enhanced efficacy safety profiles. In this regard, molecularly imprinted polymers (MIPs), synthetic receptors recognize targeted molecules high affinity selectivity, intensively investigated as one most attractive biomaterials for theragnostic approaches. This review describes diverse synthesis strategies provide rationale behind these antibodies provides selective overview recent vitro vivo targeting biomarkers diagnosis applications. Taken together, topics discussed concise guidelines development novel MIP-based systems more precisely promote successful treatment. Molecularly The aim
Language: Английский
Citations
48