Annual Review of Physiology,
Journal Year:
2018,
Volume and Issue:
81(1), P. 585 - 605
Published: Nov. 7, 2018
It
is
increasingly
clear
that
mechanotransduction
pathways
play
important
roles
in
regulating
fundamental
cellular
functions.
Of
the
basic
mechanical
functions,
determination
of
morphology
critical.
Cells
typically
use
many
mechanosensitive
steps
and
different
cell
states
to
achieve
a
polarized
shape
through
repeated
testing
microenvironment.
Indeed,
determined
by
microenvironment
periodic
activation
motility,
mechanotesting,
mechanoresponse
functions
hormones,
internal
clocks,
receptor
tyrosine
kinases.
Patterned
substrates
controlled
environments
with
defined
rigidities
limit
range
behavior
influence
state
decisions
are
thus
very
useful
for
studying
these
steps.
The
recently
rigidity
sensing
process
provides
good
example
how
cells
repeatedly
test
their
also
linked
cancer.
In
general,
aberrant
extracellular
matrix
mechanosensing
associated
numerous
conditions,
including
cardiovascular
disease,
aging,
fibrosis,
correlate
changes
tissue
composition.
Hence,
detailed
descriptions
involved
responding
needed
better
understand
both
mechanisms
homeostasis
pathomechanisms
human
disease.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Jan. 2, 2023
Abstract
Integrins
are
considered
the
main
cell-adhesion
transmembrane
receptors
that
play
multifaceted
roles
as
extracellular
matrix
(ECM)-cytoskeletal
linkers
and
transducers
in
biochemical
mechanical
signals
between
cells
their
environment
a
wide
range
of
states
health
diseases.
Integrin
functions
dependable
on
delicate
balance
active
inactive
status
via
multiple
mechanisms,
including
protein-protein
interactions,
conformational
changes,
trafficking.
Due
to
exposure
cell
surface
sensitivity
molecular
blockade,
integrins
have
been
investigated
pharmacological
targets
for
nearly
40
years,
but
given
complexity
sometimes
opposite
characteristics,
targeting
integrin
therapeutics
has
challenge.
To
date,
only
seven
drugs
successfully
marketed,
abciximab,
eptifibatide,
tirofiban,
natalizumab,
vedolizumab,
lifitegrast,
carotegrast.
Currently,
there
approximately
90
kinds
integrin-based
therapeutic
or
imaging
agents
clinical
studies,
small
molecules,
antibodies,
synthetic
mimic
peptides,
antibody–drug
conjugates
(ADCs),
chimeric
antigen
receptor
(CAR)
T-cell
therapy,
agents,
etc.
A
serious
lesson
from
past
drug
discovery
research
efforts
is
successes
rely
both
deep
understanding
integrin-regulatory
mechanisms
unmet
needs.
Herein,
we
provide
systematic
complete
review
all
family
members
integrin-mediated
downstream
signal
transduction
highlight
ongoing
develop
new
therapies/diagnoses
bench
clinic.
In
addition,
further
discuss
trend
development,
how
improve
success
rate
trials
therapies,
key
points
research,
basic
translational
research.
Biomacromolecules,
Journal Year:
2020,
Volume and Issue:
21(6), P. 1968 - 1994
Published: March 31, 2020
Synthetic
3D
extracellular
matrices
(ECMs)
find
application
in
cell
studies,
regenerative
medicine,
and
drug
discovery.
While
cells
cultured
a
monolayer
may
exhibit
unnatural
behavior
develop
very
different
phenotypes
genotypes
than
vivo,
great
efforts
materials
chemistry
have
been
devoted
to
reproducing
vitro
vivo
microenvironments.
This
requires
fine-tuning
the
biochemical
structural
actors
synthetic
ECMs.
review
will
present
fundamentals
of
ECM,
cover
chemical
features
scaffolds
used
generate
ECM
mimics,
discuss
nature
signaling
biomolecules
required
exploited
bioresponsive
microenvironments
able
induce
specific
fate,
highlight
strategies
involved
creating
functional
mimics.
